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1. Kinetics and mechanism for platination of thione-containing nucleotides and oligonucleotides: evaluation of the salt dependence.

Author

Kjellström J and Elmroth SK

Subjects
Chromatography, High Pressure Liquid methods, DNA Adducts biosynthesis, Kinetics, Magnetic Resonance Spectroscopy, Models, Chemical, Oligonucleotides metabolism, Organoplatinum Compounds metabolism, Osmolar Concentration, Perchlorates chemistry, Sodium Compounds chemistry, Spectrophotometry, Ultraviolet, Thioinosine metabolism, Thiouridine metabolism, DNA Adducts chemistry, Oligonucleotides chemistry, Organoplatinum Compounds chemistry, Thioinosine chemistry, Thiones chemistry, Thiouridine chemistry
Abstract

Reactions of cis-[PtCl(NH(3))(CyNH(2))(OH(2))](+) (Cy=cyclohexyl) with thione-containing single-stranded oligonucleotides d(T(8)XT(8)) and d(XT(16)) (X=(s6)I or (s4)U) and the mononucleotides 4-thiouridine ((s4)UMP) and 6-mercaptoinosine ((s6)IMP) have been studied in aqueous solution at pH 4.1. The reaction kinetics was followed using HPLC methodology as a function of ionic strength in the interval 5.0 mM

Published
2003
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