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Reassociation kinetics of the fragments of DNA consisting of interspersed repetitive and non-repetitive nucleotide sequences is considered in this paper. Based on the model, suggested by Gavrilov and Mazo (Mol. biol., 11, 101 1977), which takes into account the random DNA shearing, both reassociation kinetics of the total DNA in the region corresponding to interspersed repeat reassociation and that of the isolated preparation of interspersed repetitive sequences are calculated. In both cases influence of the repeat length on the reassociation rate is demonstrated. The estimation of the repetition frequency of rare repeats from pigeon genome is specified using calculations performed.

Influence of random DNA shearing on reassociation of repeated sequences separated by considerably long unique sequences has been considered theoretically. Reassociation kinetic curves have been calculated for repeated sequences of various length. Dependence of the reassociation rate constant and the repeated sequences frequency on the fraction and length of the repeated sequences has been obtained.