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The process of development and optimization of anticancer drugs entails the design, synthesis, and elucidating of a diverse range of compounds. Among these are organotin(IV) dithiocarbamate metal complexes, which offer promising potential as anti-cancer agents. Recent studies have underscored the potential of these complexes to exert encouraging anti-proliferative activities against cancer cells, which can be attributed to their distinctive molecular structures and interactions with malignant tissues. This study aimed to refine the chemical constitution of Ph2Sn (N-ethyl-N-benzyldithiocarbamate) through the application of cutting-edge analytical methods, including elemental and spectral analysis (infrared (IR) and NMR spectroscopy). Following optimization, the bioactivity of the newly designed compounds was evaluated on A549 human lung cancer cells utilizing standardized MTT assays to bring a better understanding of the structureactivity relationship (SAR). Our results indicate that these compounds display augmented cytotoxicity vis-à-vis current platinum-based chemotherapeutics, cisplatin, thereby highlighting their potential as an innovative alternative to conventional anti-cancer therapies. [ABSTRACT FROM AUTHOR]

Organotin (IV) dithiocarbamate has recently received attention as a therapeutic agent among organotin (IV) compounds. The individual properties of the organotin (IV) and dithiocarbamate moieties in the hybrid complex form a synergy of action that stimulates increased biological activity. Organotin (IV) components have been shown to play a crucial role in cytotoxicity. The biological effects of organotin compounds are believed to be influenced by the number of Sn-C bonds and the number and nature of alkyl or aryl substituents within the organotin structure. Ligands target and react with molecules while preventing unwanted changes in the biomolecules. Organotin (IV) dithiocarbamate compounds have also been shown to have a broad range of cellular, biochemical, and molecular effects, with their toxicity largely determined by their structure. Continuing the investigation of the cytotoxicity of organotin (IV) dithiocarbamates, this mini-review delves into the appropriate method for synthesis and discusses the elemental and spectroscopic analyses and potential cytotoxic effects of these compounds from articles published since 2010. [ABSTRACT FROM AUTHOR]