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The thesis deals with the process of creating a web application for distributing both test and production versions of mobile applications. The first part consists of research and a comparison of the existing solutions. The second part is focused on the design of the application, defining functionality and implementation. During the last part the application is deployed and tested by real users. After the users' feedback, the application is modified.

The main goal of this work is to evaluate the structure and volume of bioproduction from the monitored area and to suggest possibilities for its better application on the market. The work is divided into theoretical and empirical part. The theoretical part is a literature search and presents areas of organic production legislation, the Czech Republic's action plan for agricultural development in the years 2021 to 2027, the current food market, organic food distribution channels, customer decisions on orga-nic products and the sustainability of the organic food market. In the empirical part, a questionnaire survey is conducted, in which the suppliers (farmers) of the SCUK.cz platform are interviewed. Various areas of their production and distribution are exa-mined here. Subsequently, the obtained data are evaluated and interpreted, a proposal for measures to expand the volume and range of organic production in the region and its better application on the market is created and a discussion is conducted.

Author: Martin Horak Title: Marketing mix of a selected sports organization Objectives: The main objective of this bachelor thesis is to compile recommendations for individual tools of the marketing mix for a sports club. To achieve this objective, the current status must be assessed first. The application of proposed recommendations will lead to an increase in the quality of the services provided, greater satisfaction of customers and club members and an overall improvement in the functioning of the club. Methods: Qualitative research is used to analyse the marketing mix through a semi-structured interview, which is performed with the club management, with parents and with adult members of the club. Results: Suggestions for improvement of the club were created based on the assessment of the current marketing mix, Most of recommendations were made for the product and promotion, as these are very important tools for the club and they were also given the most time in the interviews. Conclusion: In the conclusion is summarized the course of the work and the most important suggestions for improvement. There are some interesting and complicated proposals are too. Keywords: marketing, marketing research, sports club, taekwondo, training, product, price, promotion, distribution, people, process,...

Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Dominika Bezděková Supervisor: doc. PharmDr. Lukáš Červený, Ph.D. Title of diploma thesis: IN VITRO STUDY OF DRUG-DRUG INTERACTIONS OF HIV PROTEASE INHIBITOR DARUNAVIR ON EFFLUX ABC TRANSPORTERS Abstract: Darunavir is a drug used in the therapy of HIV belonging to the group of protease inhibitors. These protease inhibitors are used as a part of the combination antiretroviral therapy. For the increase of bioavailability, darunavir is always used in combination with ritonavir or cobicistat. As the CYP3A4 and ABCB1 (P-glycoprotein) transporter substrate, darunavir is a drug with a high potential to drug interactions. Considering the amount of adverse effects that can be caused by darunavir, it is necessary to know these drug interactions for the safety of therapy. Inhibition of the intestinal ABCB1 by the co-administrated drugs could also lead to the increased bioavailability of darunavir and to reduction of frequency of administration leading to a cheaper therapy. This thesis studies the drug-drug interactions of darunavir with in vitro methods using two cell lines - MDCKII and Caco-2 cells. The results from the transport of darunavir across the MDCKII cell monolayer indicates that darunavir is a ABCB1...

Distribution and ecology of colourless euglenoids was studied on more than four hundred localities in each region of the Czech Republic. In this study, a checklist of observed taxa, description of chosen taxa and several ecological statistics were made and discussed.

This paper focuses on the changes in distribution of television content which emerged during the process of convergence between television and digital media. Nowadays it is possible not only to access television broadcasting online, but also to access individual programs through Video on Demand services. The precondition this topic was picked on is that the very existence of such services has a direct impact on the form of today's television broadcasting. Therefore the aim of this paper is to examine and describe alterations which can be found not only in the broadcasting itself but also in receiving of that broadcasting on television screens. The latter can be affected by the existence of HbbTV. The analysis and description of changes in broadcasting and receiving television content in Czech republic are the primary focuses of this paper.

Legal regulation of consumer credit in the Czech republic Abstract This diploma thesis deals with the topic of consumer credit distribution in the Czech Republic. Recently, the European level of regulation of the provision and intermediation of consumer credit has undergone a major change. In connection with that also individual Member States had to transpose the revolutionary Directive 2014/17/EU which extends consumer protection to loans concerning real estate. This was executed in the Czech Republic by the adoption of the Act No. 257/2016 Sb., which came into effect on 1 December 2016. The paper is divided into four parts, in which the author describes and evaluates the current state of consumer credit distribution regulation. For this purpose, the provisions of the Act and their interpretation using accompanying documents are subject to analysis and evaluation of their conformity with the objectives of the regulation. The first part describes the historical context and development of consumer credit from the beginnings of the western civilization to the present state, focusing on the European Union as the originator of our national consumer credit legislation. The second part is devoted to general aspects of consumer credit provision, especially the scope of the Consumer Credit Act and other general...

Nuclear weapons testing in the atmosphere and accidents in nuclear energy facilities in the last 50 years caused significant contamination of the environment. Half-life of certain leaked radionuclides is several decades and therefore they are still present in today's environment. That is the reason why there is still on going monitoring of radiation situation in the Czech Republic in order to determine the behaviour and kinetics of anthropogenic radionuclides in the environment and the severity of radiological impact on humans. The results of this monitoring serve to review the radiation situation, observe long-term trends and last but not least to gain new knowledge that could facilitate the management od radiological emergencies. The aim of this thesis was to measure the content of 137Cs in soils under and around leafy tree crowns in the area affected by radiation fall and to find out whether the tree's crown has an effect on the distribution of 137Cs in the soils below them. To this end, a research question has been set: Do tree crowns affect the distribution of cesium in the soils below them? For better intelligibility, the introduction of the thesis is devoted to information about ionizing radiation, basic terms and quantities in the field of ionizing radiation, sources of radionuclide contamination, especially the Chernobyl nuclear power plant accident, environmental and population contamination, and elements important for the practical part of this work. The theoretical part is followed by research methodology. The soil samples were collected under five leafy trees of the Walnut species that met the set criteria for collection. Under each tree, samples were taken in three directions at an angle of 120° always at the trunk, in the middle of the crown, at the edge of the crown and outside the crown. Thus, 12 samples per tree, a total of 60 samples. Dry and purified soil samples were measured by semiconductor gamma spectrometry which determined 137Cs radionuclide mass activity values as well as naturally occurring radionuclide40K. Graphs were generated from the measured values. Despite the frequent deviations that may be caused by natural phenomena or human activities, it was found out that tree crowns affect the distribution of 137Cs in the soils below them.

v anglickém jazyce Theoretical and Practical Aspect of Unit-linked Insurance Abstract United-linked insurance (ULI) is the most widely sold type of life insurance in the Czech Republic; frequently, however, this product is sold to clients without respecting their investment profile and financial needs (mis-selling); mis-selling, in turn, results in the loss of confidence in the system of financial distribution and its efficiency. Even though the current legislation offers tools to mitigate mis-selling (not only) of ULI, in practice such legal regulation proves to be insufficient. The causes of this relate to both the distributors and their customers, as well as to the financial products themselves. Behavioural research has proven marked shortcomings in the economic and legal understanding of a human being as a homo economicus, i.e. as a rationally acting agent. A number of studies evidence that people oftentimes demonstrate limited rationality, which negatively impacts financial distribution, in that these cognitive errors may be purposefully and skilfully abused by distributors who use their marketing and sales strategies to the clients' disadvantage. In this respect, this thesis analyses the current financial-political customer protection doctrines; the status of the ULI customer protection,...

Bachelor thesis deals with the calculation of the distribution of an aggregated claim: at first generally and afterward, focusing on life portfolio in an indivi- dual model. Three methods are compared: De Pril recursion, Kornya's method, and Panjer algorithm. We assess assumptions and derive formulae for particular methods. Methods are compared in terms of time complexity and precision of computations. We also deal with the calculation of the expected value and va- riance. Eventually, examples and simulations, which we used to determine the best method of calculation of the distribution of aggregated claim in an arbitrary portfolio, are preceded.

Aim of this study was to assess distribution and abundance of common synanthropic species of birds (House sparrow, Tree sparrow, Eurasian collared dove and Blackbird) in area of the city České Budějovice in the Czech Republic in autumn and winter. Habitat preferences of these species were analysed. Study also determined influence of the certain characteristics of urban vegetation on their occupation by both species of sparrows.

This thesis provides a comparison of the insurance market in the Czech Republic with select countries around the world. The main aim of the thesis is to identify differences in motor insurance in ten select countries around the world. The author defines various types of products and their differences, provides a comparison of insurance markets in relation to: legislation and the definition of certain products. In order to provide appropriate coverage, the author uses a method of indexation and absolute price. As a result of this work the reader will be better able to select the best insurance product available on a given market for the customer based on a set of conditions.

In my work I focused on opportunities and barriers to the introduction of organic food in school catering facilities and finding satisfaction diners. The theoretical part describes the scope and structure of organic farming, production, distribution and use of organic products in the Czech Republic and in the region Klatovsko. The emphasis is on organic food consumption, ways of their sales and the offered range. Further, are mention the factors and agents that affect the use of organic food in catering establishments. In the practical part was carried out a survey in selected school canteens and schools at Klatovsko. In the work were observe view of students elementary abd secondary schools on catering, diversity of dishes, employee access or weaknesses which should be improved. For employees of catering equipment was checked usage of local produce, organic and seasonal food in the menus.

The aim of this work was to provide a comprehensive overview of published findings regarding thyroid, thyroid hormones, their concentrations, stability in the aquatic environment and effect on fish. To determine the consumption of synthetic thyroid hormones in the Czech Republic, the data on the distribution of the drugs, in which they are contained, is analyzed over a period of five years (2011 - 2015). This has provided information about the issued amount of active ingredients i.e. levothyroxine (T4) and liothyronine (T3) for each year. T4 consumption increased over five years, except for 2013, with the highest consumption in 2015 corresponding to 34.6 kg of T4. T3 consumption ranged only in tens of grams before prescribing drugs containing T3 in the Czech Republic was ceased in September 2013. Based on the distribution of synthetic thyroid hormones, an estimate of concentrations that could normally occur in surface water was performed (PECRIVER). Two variants of the calculation were performed. The first variant was based on consumption of synthetic thyroid hormones. The second variant was based on excretion of thyroid hormones (including natural ones) by humans. Each of these variants was counted with the F value, i.e. the rate of removal of the chemical during the WWTP wastewater treatment process, from two different sources. The first source was the study by Svanfelt et al. (2010) where the efficacy of thyroid hormone removal during the WWTP purification process was 66% for T4 (this value was not determined for T3). The second source was EPI Suite software, which calculated the theoretical efficacy of removal of T4 and T3 at WWTP (35.83% for T4 and 5.36% for T3). The resulting concentrations were relatively low in the first variant. The median of the estimated concentrations of thyroid hormones in surface water with the efficacy of removing thyroid hormones during the WWTP purification process, taken from the study by Svanfelt et al. (2010), ranged from 0.6 - 0.7 ng-l-1 for T4. Using the theoretical value of the elimination rate calculated using the EPI Suite program, the median ranged from 1.1 to 1.3 ng-l-1 for T4 and from 0.0007 to 0.0025 ng-l-1 for T3 before it ceased to be used in September 2013. In the second variant, the resulting concentrations were somewhat higher. Median of the environmental concentrations of thyroid hormone with the removal rate taken from the study by Svanfelt et al. (2010) was determined to 1.5 ng-l-1 for T4. With the EPI Suite removal efficacy, the median was determined to 2.9 ng-l-1 for T4 and 0.13 ng-l-1 for T3. Estimated concentrations of thyroid hormones in surface water may currently seem relatively low to have a significant effect on fish, since the lowest thyroid hormone concentration at which any effect was observed ranged in tens of ng-l-1. However, it should be borne in mind that thyroid hormones enter the surface water as a result of incomplete removal during waste water treatment and fish are exposed to these hormones over a long period of time, meaning that even seemingly low concentration may pose a potential risk to aquatic organisms including fish. The fate of these hormones in the environment is therefore to be judged by further studies and toxicological experiments.

The aim of this thesis is to explain the importance of the internet and online travel agencies as one of the most important parts in the distribution of accommodation. The thesis includes a demonstration of cooperation between a particular accommodation establishment and its OTAs, which are also analysed. In conclusion, are suggested measures leading to optimize the distribution.

Revision of pre-optimalization state and proposal of possible changes with a focus on lowering the transportation costs, optimizing the routing and also the service level provided to the customers. Optimalization done on several levels, on strategical and on operative level. All this achieved with combination of outputs from a routing software and using intuitive methods. Outcome to be accounted in costs per annum. Based on conditions and demands stated by the logistics manager in the contrary to customers demands, a strategy of warehouse allocation was created. Based on this information a distribution model regarding also the routing issue was created as well.

The bachelor thesis deals with distribution methods of operating environments, i.e. operating systems, software and specific configurations. In the thesis, chosen methods (local virtualization, remote software installation, hard drive cloning, cloud computing and remote terminal services) are described. Different distribution methods are evaluated using our own criteria. Four model institutions of different size are considered. Results of the case study are reported in the final part.

The sexual segregation, defined as different use of space by sexes is widespread phenomenon in the animal tree of life. As a result of segregation there is a different use of resources such as habitat, prey items or different threat by predation. Nevertheless it is not well studied in fish taxa except in marine environment. The common and widespread freshwater species such as a bream (Abramis brama), a bleak (Alburnus alburnus) and a roach (Rutilus rutilus) so far have not never been studied from the perspective of sexual segregation too. This thesis aims to examine the sexual segregation of these species and to test premises of sexual segregation such as sexual size dimorphism, age composition and differences in food. Afterwards the different space use of sexes in the Římov reservoir was tested. The gillnet sampling was used to collect data. Gillnets were installed to four localities in longitudinal gradient of reservoir in epilimnion where is the highest abundance of fish. Sampling was performed in August from 2009 to 2016. Results of this thesis show that females and males have different life histories and that bleak and roach are significantly bigger and older than males. The size dimorphism in bream was confirmed but not age difference between sexes. Sexes of bream had different diet. Males...

This thesis is devoted to a draft of an teaching material for the subject of Logistcs at the Agricultural faculty of University of South Bohemia, which is specifically designed for the follow up field of study of Agricultural and transport technologies.

The topic of this thesis is the analysis of goods distribution at promotional events. By the promotion event in this thesis we consider actions of event marketing and the support of the sale in the place of selling. The aim of my thesis is the analysis of distribution and the optimization of current solution. The theoretical part describes the clarification of chosen terms from marketing communication and distribution. The practical part is dedicated to the analysis of goods distribution at promotional events of the company selling non-alcoholic beverages. In the end of the thesis I suggest the improvement of the current situation in the distribution considering the costs and time.

This masters thesis aims to explore the possible implementation of the direct distribution model within the automotive industry. The goal is to outline the possible distribution strategy, using the direct distribution model, for an auto manufacturer. The theoretical background and cases that are used to describe the practical usage of the model are based on a secondary research. More specific aspects of the distribution model are then based on interviews conducted with professionals from the automotive industry. The proposed distribution strategy consists of combination of several direct distribution models. Different models are used due to the distinct nature of the products, considered in the process of new distribution model design. The implementation would allow the OEM to gain more control over the distribution process and create more efficient distribution system.

Bachelor thesis Short film and its distribution explores the phenomenon of the short film and its possible spread. Thesis deals with the definition of short film and film distribution. By using the interviews will be held to analyze the possibilities of distribution of short films. Based on these interviews, the reader will be able to get a rough idea of how one can currently run film distribution of this type of film.

The aim of this article is to explore the possibility of increasing the sale of organic products through supplying schools and school canteens. Potential of this way of commercialization of organic production is assessed based on the survey on preschools and elementary schools and among parents of children attending the surveyed schools. The article is based on the local survey in the district of České Budějovice and additionally on the results of a national survey that have, however, omitted the region of South Bohemia. Only about one fifth of pre-schools and elementary schools have already experienced the involvement of organic food in the school meals preparation. Some of them are not interested in organic food but most of them fear the strong increase of the school meal’s price when using ingredients originated from organic farming. Most parents are interested in inclusion of organic food in the school meals but they also worry about the price. Model cases proved, however, that the increase of the price is not so dramatic, and the real increase of the price corresponds with most parents’ willingness to pay higher prices for meals with organic food content., Cílem tohoto článku je prozkoumat možnosti zvýšení odbytu bioproduktů prostřednictvím zásobování škol, školek a školních jídelen. Potenciál této formy zpeněžování bioprodukce a odbytu biopotravin je posuzován na základě výzkumu mezi mateřskými a základními školami a také mezi rodiči dětí navštěvujících zkoumaná zařízení. Tento článek se opírá o primární výzkum realizovaný v okrese České Budějovice a dále pak sekundárně o výsledky celostátního průzkumu, který však bohužel vůbec nezahrnul školy a mateřské školy z jižních Čech. Pouze přibližně jedna pětina mateřských a základních škol má již zkušenosti s využitím biopotravin při přípravě jídel pro děti. Některé z nich sice nejeví o biopotraviny zájem, většina z nich však zájem má, ale obává se významného zvýšení ceny jídel při použití bioingrediencí. Většina rodičů má rovněž zájem o zavedení biopotravin do přípravy školních jídel a shodně vyjadřuje obavy o zvýšení ceny. Modelové případy však ukázaly, že nárůst ceny při používání biopotravin není nikterak dramatický a skutečný nárůst ceny je v rámci ochoty rodičů připlatit pro své děti za jídlo s obsahem biopotravin.

The topic of this thesis is "Planning, production and distribution in selected company." The aim of this thesis was to recommend some suggestions which could lead to improvements in the selected company. This thesis is composed of theoretical and practical parts. The theoretical part describes the contents of each chapter. This section was written on the basis of domestic and foreign literary sources. This work is focused on analysis of current situation in chosen company for the calendar year 2015 in section of production, planning, capacity utilization, material and information flow, distribution and new product development. At the end of the practical part are recommended the proposals for improvement.

Článek se zabývá problematikou e-commerce z hlediska marketingového mixu podniků, kdy může být e-commerce neboli elektronické obchodování využito jako jeden z marketingových nástrojů a může se stát zásadním aspektem z hlediska konkurenční výhody na trhu. Příspěvek analyzuje využití elektronického obchodování k nákupu zboží a služeb uživateli internetu ze zemí Evropské unie v letech 2007-2015 a sleduje jeho vývoj. The article deals with problems of e-commerce from the marketing mix point of view. It focuses on companies which could use e-commerce as one of marketing tools to obtain competitive advantage in the market. The development of utilization of e-commerce in the shopping process of Internet users in European Union in years 2007 and 2015 is also analysed in this article.

in English language Distribution of financial instruments This thesis deals with the issue of distribution of financial instruments and its legal regulation. The aim of the thesis is to theoretically define, within the financial law systematically classify and analyze the issue of legal framework for the distribution of financial instruments. The secondary objective is to highlight the partial incoherence of legislation regulating the various forms of distribution and propose possible solutions. The first two chapters of this thesis are devoted to general theoretical issues related to the present topic, among others to the concepts of distribution in the financial market and financial instrument. The third chapter deals with investors as addressees of distribution and with the various categories of distributors and analyzes the extent of their qualification in the area of distribution of financial instruments. The chapter four analyzes the different legal forms of distribution of financial instruments with a focus on marketing of investment funds. Within particular chapters, author's views on the issue are given, including proposals de lege ferenda. Finally, the draft of legislative amendments in the area of distribution of financial instruments, representing participation in the investment fund is...

The bachelor thesis "Marketing communication of the alternative content in cinematic distributions" describes the phenomenon of alternative content - live cinematic streamings of opera, ballet, theatre shows, exhibitions tours, sports games and other events. Over a few years, these screenings became a regular part of Czech cinema's programme. The theoretical part of the thesis describes the concept of art marketing, its specifics and development. The next part of the thesis characterizes the history of the alternative content and the circumstances that enabled its introduction to the market. This part also outlines the specific kinds of alternative content screenings. The practical part of the thesis shortly introduces the Aerofilms company, the main distributor of the alternative content at the Czech market and it analyses the marketing communication of several alternative content screenings. Afterwards, the specifics, which are connected with the marketing communication of the alternative content are determined.

This thesis will focus on movie distribution via internet, especially on American movie service Netlix and its impact on recent entry to Czech movie market. In the theoretical part will be processed summary of past and recent movie distribution windows. In the practical part will be processed survey, which purpose will be to find out how did Netflix succeed to get into awareness of consumers of the film culture in the Czech republic.

We are currently witnessing the transformation of media landscape since transmedia contents affect the strategy of distributors, producers, and television broadcasters. This new phenomenon has multidisciplinary overlap, so we encounter with different interpretations and terminology in this discourse. The master thesis Transformation of distribution of audiovisual content in transmedia context has two main objectives. Its primary aim is to unify the basic terminology for media, audiovisual, and distribution discourse based on academic literature. The secondary aim is to explore the strategies of 3 largest domestic terrestrial TV broadcasters through formal analysis. The practical part is divided in 2 sections. The first one is focused on how TV stations have implemented transmedia extensions in the context of audience immersion and broadcasters branding in their distribution strategies. The second examines whether there is true transmedia content for original shows and storyworlds in their production. It is just a matter of time before these changes in distribution strategies will affect TV broadcasters. Transmedia extentions are associated with a creative process since ancient times but we could not realize their existence. Keywords transmedia, crossmedia, transmedia storytelling, convergence,...

Protists are ubiquitous organisms, they are main particles in foodchains, but they also cause many economical problems in areas of healthcare, agriculture and in food industry. Their biogeography is discussed in many academical debates and even that our methods are relatively advanced, there is still not only one accepted theory but two of them. However it is true that the moderate endemicity model is probably the correct one. This text sums up our existing knowledge in the field of protist distribution and their dispersal over whole planet, in terrestrial and aquatic environments. Mechanisms of dispersal are very coplicated and complex problematics. The resting stages are also important for successful dispersal, not only as a reaction to unfavourable conditions. Dispersal is affected by climatic conditions in investigated area and thus it is not easy to predict the patterns of dispersal. Human influence is getting more important on biogeography of microorganisms, including the history. This topic is becoming more popular these days as it becomes obvious it is importnat to know the patterns of dispersal. There are also adaptations and tolerances discussed. Keywords: environmental factors, dispersal, distribution, endemic species

The present master´s thesis examines logistics processes in the company MILK- AGRO, spol. s. r. o., which focuses on food industry. The aim of the thesis is to analyse current processes in the company and propose improvements in cutting costs. Attention is paid to current stocking process and distribution of goods. The thesis includes theoretical basis of Green Logistics, its legislative requirements and smooth implementation which means the creation of a new green product for the company. Furthemore, there is an implementation of Reverse Logistics in the thesis based on detailed distribution information. The theoretical part of new product analyses legislative, motivational and distribution point of view. Additionally, the master´s thesis clarifies benefits and drawbacks of Reverse Logistics within the company. Lastly, the author recommends improvements in warehousing and a new distribution route.

The thesis analyses legal environment of the financial services market in relation with business practice of retail financial products distribution in Czech republic. It describes current legislation and instruments of regulation of the distributional activities both on national and supra-national (european) level. Furthermore, it introduces the development of regulation in light of identified weaknesses of legislation, leading to specific recommendations and measures ensuring vast consumer protection and fixing the level-playing-field in distribution throughout various sectors of financial markets and their layovers. The conclusions are based on author´s theoretical studies of economic and legal context and private business practice.

This bachelor thesis will discuss franchising as a business model. The structure of this thesis is the following; firstly I describe franchising and its context and secondly I apply the theory on the company Dancing Crackers. The purpose of this thesis is to line up steps and prepare a plan for the realisation of a franchise project. I start with the more general perspective and then move on to the practical aspect of the thesis. Based on the lined up steps which were applied to the company Dancing Crackers I have concluded several findings which allow me to argue for methods that increase effectiveness of franchising processes. This was concluded based on methods of observation.

The aim of this bachelor thesis was to make an overview of distribution of beta-blockers and calcium channel blockers, their occurrence in aquatic environment and their impact on fish. Analysis of data obtained from the website of the State Instiute for Drug Control, which was carried out in Excel revealed, that 53 643 kilograms of beta-blockers and 24 472 kilograms of calcium channel blockers was distributed in the Czech Republic in 2011. Metoprolol, acebutlol and atenolol reached the largem volume of distribution among aktive ingredients in the group of beta-blockers. Verapamil, amlodipin and diltiazem were TOP 3 calcium channel blockers. These drugs are generally the most sold in the world and they can be found in surface waters in the Czech Republic and worldwide at concentrations rating from tens to hundreds ng.l-1 . The reason for this is the low removal rate of beta-blockers and calcium channel blockers in wastewater treatment plants, which ranges from 11 to 76%. Toxicity tests on fish with metoprolol, propranolol, atenolol, verapamil and diltiazem have shown the effect of this pharmaceuticals on e.g., reduction of fecundity, hatchability or heart rate. Various histopatological changes on the liver and heart or malformations of early developmental stages of fis have been also reported. The lowest concentrations of the tested substances at which these effects were observed, ranged mostly from values g.l-1 to mg.l-1, i.e. these concentrations were higher than those commonly found in surface waters. However, some effects were observed also at environmentally relevant concentrations. Due to prolong-term exposure on the organisms beta-blockers and calcium channel blockers may represent a threat to aquatic ecosystems. A solution could be to improve the mechanism for removal of pharmaceuticals in the sewage treatment plants.

This Bachelor thesis deals with the analysis of the logistics processes in the pharmaceutical company Takeda Pharmaceuticals Russia LLC. This thesis is divided into two parts. The theoretical part explains the basic concepts of logistics. The practical part is focused on the description of the logistics operations that take place in a chosen company. The aim of this work is to identify weaknesses in the existing logistics system and to propose suitable solutions that could lead to the optimization of logistics processes.

The bachelor thesis deals with the issue of marketing mix of the company Mistral Paints s.r.o. The aim of this thesis is to analyse and optimise marketing mix of this company. In first, theoretical part is explained essential terms with application of expert literature. Second, practical part is divided into four subheads. First subhead contains deeper presentation of the company Mistral Paints s.r.o. Next article is about analysis of macro and micro surroundings, which can hepl us with understanding the situation on the market and it is reflected even in marketing mix. Last but not least subhead of this thesis is analysis of marketing mix and its optimization with suggestions to future. There is gradually processed every factor of marketing mix 4P.