1. "Exogenous" 5 Alpha Reductase Deficiency: A Case Report.
- Author
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Levy B, Teplitsky S, Kalaitzoglou E, Kahler S, Matheny JP, and Saltzman AF
- Subjects
- Pregnancy, Humans, Male, Female, Gender Identity, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase, Testosterone therapeutic use, Dihydrotestosterone, Cholestenone 5 alpha-Reductase, Disorders of Sex Development
- Abstract
Testosterone and dihydrotestosterone are significant drivers of male external genital development, and therefore teratogens that alter these hormone profiles have been hypothesized to cause aberrations in development. Here, we present the first case report of genitalia anomalies after prenatal exposure to spironolactone and dutasteride through 8-weeks of gestation. The patient was born with abnormal male external genitalia which was surgically managed. Long-term outcomes such as gender identity, sexual function, hormonal maturation through puberty, and fertility remain unknown. These numerous considerations necessitate multi-disciplinary management with close follow-up to address sexual, psychological, and anatomic concerns., Competing Interests: Declaration of Competing Interest None declared., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
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