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An edge dislocation with a time-dependent Burgers vector in an orthotropic plane is analyzed. The stress field caused by a dynamic point force in the intact plane is determined. The displacement discontinuity of dislocation and direction of point load are at arbitrary angles with the Material Principal Axes (MPA), the general orthotropic plane. The density of dislocations is employed to construct integral equations for orthotropic planes weakened by several interacting cracks, making arbitrary angles with the MPA. The numerical solution of integral equations results in the density of dislocations on a crack surface. The results are employed to determine time-dependent Stress Intensity Factors (SIFs) at the tips of a crack and Crack Opening Displacement (COD). In the problem of general orthotropic planes containing cracks subjected to dynamic loads, crack orientations may cause their partial/total closing. Under the hypothesis of frictionless contact, we devise an iterative procedure to handle crack closing, as well. By contrast to cracks in the directions of MPA, expressions for the two modes of SIFs contain the density functions of both the climb and glide of the edge dislocation. Therefore, mode I SIF at an open tip of a crack may not be positive. Conversely, positive mode I SIF may occur at a closed crack tip. Numerical results of the SIFs and COD for several examples of orthotropic planes under dynamic point loads, while weakened by single and double parallel cracks, are presented. Moreover, in double cracks cases, the interaction between cracks is studied. [ABSTRACT FROM AUTHOR]