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Yassin Abdelrahim Abdalla,1 Arwa Mustafa Kamil,2 Samya Abbas Abdelrazig Mohamed,3 Ahmed Hashim Ahmed Mohamed,4 Eman Khalifa,5 Mohamed Hamid Abdelsalam Mohamed,2 Eilaf Eltayeb Abdalla Abdelgadir,6 Muawiya Dabora,7 Mohammed Salah Eldin Mohammed Elshikh Awoda8 1Internal Medicine Department, Faculty of Medicine and Health Science, Omdurman Islamic University, Khartoum, Sudan; 2MBBS, Alzaiem Alazhari University, Khartoum, Sudan; 3MBBS, Al Gezira University, Wadmedani, Sudan; 4MBBS, National Ribat University, Khartoum, Sudan; 5MBBS, University of Khartoum, Khartoum, Sudan; 6MBBS, Alneelain University, Khartoum, Sudan; 7Department of Surgery, Alshuhada Teaching Hospital, Khrtoum, Sudan; 8Surgery Department, National Ribat University, Khartoum, SudanCorrespondence: Yassin Abdelrahim Abdalla, Email yasinabdo96@gmail.comBackground: Hospital-acquired thrombosis (HAT) is associated with significant morbidity, mortality, and financial burden globally. Following trusted guidelines for VTE prevention has shown effective, safe, and satisfactory results. This prompts national collaborative efforts to maintain a consensus approach for the safe risk assessment of inpatients and the prescription of thromboprophylaxis.Objective: This study aimed to detect and estimate deviations from international thromboprophylaxis protocols. The study also aimed to raise the quality of practice and adherence to evidence-based protocols in Alshuhada Teaching Hospital.Methods: A cross-sectional audit of general surgical inpatients was performed from October 2021 to May 2022. The first cycle was from 1/10/2021 to 21/10/2021, and the second cycle was from 13/5/2022 to 31/5/2022. The target population was adults aged > 18 years. Data were collected via an online checklist on two separate occasions. The criteria were based on the NICE guideline for venous thromboembolism in individuals aged over 16 years: “Reducing the risk of hospital-acquired deep vein thrombosis or pulmonary embolism NG89”.Results: Forty-five surgical inpatients were included in this study: 20 in the first cycle and 25 in the second cycle. The first-cycle report showed that only 25% of VTE candidates received this regimen. In the second cycle, practice significantly improved, with 92% of admitted patients having their risk assessment tool completed within 24 h of admission. 79% of VTE prophylaxis candidates were prescribed adequate pharmacological prophylaxis within 14 h of admission.Conclusion: The rate of adequate thromboprophylaxis for inpatients undergoing surgery was very low before clinicians received education on VTE prevention, whereas was evidently high after they had received them. The cause of non-adherence in the pre-intervention phase was a lack of adequate knowledge regarding the magnitude and burden of HAT and the importance of thromboprophylaxis, which has a potential role in preventing the majority of HAT.Keywords: hospital acquired thrombosis, deep vein thrombosis, pulmonary embolism, venous thromboembolism