1. Nicotine in thirdhand smoke residue predicts relapse from smoking cessation: A pilot study.
- Author
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Matt, Georg E., Mahabee-Gittens, E. Melinda, Zakarian, Joy M., Quintana, Penelope J.E., Hoh, Eunha, and Myers, Mark
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SMOKING cessation , *NICOTINE , *LIQUID chromatography-mass spectrometry , *PILOT projects , *RESEARCH , *DUST , *LIQUID chromatography , *RESEARCH methodology , *INDOOR air pollution , *EVALUATION research , *MEDICAL cooperation , *DISEASE relapse , *COMPARATIVE studies , *MASS spectrometry , *RESEARCH funding , *PASSIVE smoking - Abstract
Introduction: Thirdhand smoke (THS) residue lingers for months in homes of former smokers and may play a role in relapse after smoking cessation. This study examined the association between THS pollution as measured by the level of nicotine in house dust and continued abstinence from smoking.Methods: Participants were 65 cigarette smokers who reported they were enrolled in any type of smoking cessation program, had set a specific date to quit, and had biochemical verification of continuous abstinence at 1-week (W1), 1-month (M1), 3-months (M3), or 6-months (M6) after their quit date. House dust samples collected at baseline before quitting were analyzed for nicotine concentration (μg/g) and nicotine loading (μg/m2) using liquid chromatography-tandem mass spectrometry (LC-MS/MS).Results: Controlling for age, gender, overall and indoor smoking rates, and years lived in their home, dust nicotine concentration and loading predicted abstinence at W1, M1, M3, and M6. A 10-fold increase in dust nicotine loading and concentration were associated with approximately 50% lower odds of remaining abstinent.Conclusions: Findings suggest nicotine in house dust may play a role in facilitating relapse after smoking cessation. Additional research is warranted to investigate the causal role of THS residue in homes of former smokers on cravings and continued abstinence. [ABSTRACT FROM AUTHOR]- Published
- 2019
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