1. Alanine aminotransferase elevation varies by ethnicity among Asian and Pacific Islander children with overweight or obesity.
- Author
-
Lee, Catherine, Schwimmer, Jeffrey B., Gunderson, Erica P., Goyal, Nidhi P., Darbinian, Jeanne A., Greenspan, Louise C., and Lo, Joan C.
- Subjects
METABOLIC disorders ,NON-alcoholic fatty liver disease ,RISK assessment ,STATISTICAL correlation ,HAWAIIANS ,CROSS-sectional method ,ASIAN Americans ,RESEARCH funding ,BODY mass index ,SOUTHEAST Asian Americans ,LOGISTIC regression analysis ,SEX distribution ,DISEASE prevalence ,DESCRIPTIVE statistics ,CHINESE Americans ,SOUTH Asian Americans ,WHITE people ,SEVERITY of illness index ,PACIFIC Islander Americans ,RACE ,ODDS ratio ,ALANINE aminotransferase ,RESEARCH ,CHILDHOOD obesity ,COMPARATIVE studies ,BIOMARKERS ,FILIPINO Americans ,DISEASE risk factors ,DISEASE complications ,ADOLESCENCE ,CHILDREN - Abstract
Summary: Background: Limited research on alanine aminotransferase (ALT) screening for metabolic dysfunction‐associated steatotic liver disease (MASLD) among US Asian/Pacific Islander (PI) children necessitates investigation in this heterogeneous population. Objective: Examine ALT elevation among Asian/PI children with overweight or obesity. Methods: Elevated ALT prevalence (clinical threshold) and association with body mass index ≥85th percentile were compared among 18 402 Asian/PI and 25 376 non‐Hispanic White (NHW) children aged 9–17 years using logistic regression. Results: ALT elevation was more prevalent among Asian/PI (vs. NHW) males with overweight (4.0% vs. 2.7%), moderate (7.8% vs. 5.3%) and severe obesity (16.6% vs. 11.5%), and females with moderate (5.1% vs. 3.0%) and severe obesity (10.2% vs. 5.2%). Adjusted odds of elevated ALT were 1.6‐fold and ~2‐fold higher for Asian/PI (vs. NHW) males and females (with obesity), respectively. Filipino, Chinese and Southeast Asian males had 1.7–2.1‐fold higher odds, but Native Hawaiian/PI (NHPI) and South Asian males did not significantly differ (vs. NHW). Filipina and Chinese females with obesity had >2‐fold higher odds, Southeast and South Asian females did not differ and NHPI findings were mixed (vs. NHW). Conclusion: High elevated ALT prevalence among Asian/PI children with overweight and obesity emphasizes the need for MASLD risk assessment and examination of ethnic subgroups. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF