1. Candidate mechanisms linking insomnia disorder to Alzheimer’s disease risk
- Author
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M G Chappel-Farley, Kitty K. Lui, Bryce A. Mander, Abhishek Dave, and I Y Chen
- Subjects
Future studies ,Short sleep ,business.industry ,Disease expression ,Cognitive Neuroscience ,05 social sciences ,Circadian dysregulation ,Disease ,050105 experimental psychology ,nervous system diseases ,Fight-or-flight response ,03 medical and health sciences ,Behavioral Neuroscience ,Psychiatry and Mental health ,0302 clinical medicine ,mental disorders ,Disease risk ,Insomnia ,medicine ,0501 psychology and cognitive sciences ,medicine.symptom ,business ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Recent meta-analyses suggest that insomnia specifically confers risk for Alzheimer’s Disease (AD); however, the precise mechanisms by which this occurs are not well understood. In this review, we discuss candidate mechanisms linking insomnia features to AD neuropathophysiology, potentially driving increased AD risk in insomnia patients. First, we discuss epidemiological evidence tying insomnia to AD and summarize the behavioral and neurobiological features of insomnia, as well as AD pathologies. We propose that facets of hyperarousal, a central etiological feature of insomnia, act upon underlying mechanisms contributing to AD pathogenesis. Additionally, we outline how objective short sleep duration and circadian dysregulation, other key aspects of insomnia, may act as compounding pathways to exacerbate disease expression. We close with recommendations for future studies. more...
- Published
- 2020
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