6 results on '"Feng, Zhiyun"'
Search Results
2. Traumatic vertebra and endplate fractures promote adjacent disc degeneration: evidence from a clinical MR follow-up study
- Author
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Lu, Xuan, Zhu, Zhiwei, Pan, Jianjiang, Feng, Zhiyun, Lv, Xiaoqiang, Battié, Michele C., and Wang, Yue
- Published
- 2022
- Full Text
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3. Traumatic vertebra and endplate fractures promote adjacent disc degeneration: evidence from a clinical MR follow-up study.
- Author
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Lu, Xuan, Zhu, Zhiwei, Pan, Jianjiang, Feng, Zhiyun, Lv, Xiaoqiang, Battié, Michele C., and Wang, Yue
- Subjects
VERTEBRAL fractures ,MAGNETIC resonance imaging ,MAGNETIC resonance - Abstract
Objectives: The integrity of endplate is important for maintaining the health of adjacent disc and trabeculae. Yet, pathological impacts of traumatic vertebra and endplate fractures were less studied using clinical approaches. This study aims to investigate their effects on the development of adjacent disc degeneration, segmental kyphosis, Modic changes (MCs), and high-intensity zones (HIZs). Materials and methods: Magnetic resonance (MR) images of patients with acute traumatic vertebral compression fractures (T11-L5) were studied. On MR images, endplate fractures were evaluated as present or absent. Disc signal, height, bulging area, sagittal Cobb angle, MCs, and HIZs were measured on baseline and follow-up MR images to study the changes of the disc in relation to vertebra fractures and endplate fractures. Results: Ninety-seven patients were followed up for 15.4 ± 14.0 months. There were 123 fractured vertebrae, including 79 (64.2%) with endplate fractures and 44 (35.8%) without. Both the adjacent and control discs decreased in signal and height over time (p < 0.001), and the disc adjacent to vertebral fractures had greater signal and height loss than the control disc (p < 0.05). In the presence of endplate fractures, the adjacent discs had greater signal decrease in follow-up (p < 0.05), as compared to those without endplate fractures. Sagittal Cobb angle significantly increased in segments with endplate fractures (p < 0.05). Vertebra fractures were associated with new occurrence of MCs in the fractured vertebra (p < 0.001) but not HIZs in the adjacent disc. Conclusions: Traumatic vertebral fractures were associated with accelerated adjacent disc degeneration, which appears to be further promoted by concomitant endplate fractures. Endplate fractures were associated with progression of segmental kyphosis. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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4. Lumbar Vertebral Endplate Defects on Magnetic Resonance Images: Classification, Distribution Patterns, and Associations with Modic Changes and Disc Degeneration.
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Feng, Zhiyun, Liu, Yuanhao, Yang, Ge, Battié, Michele C., Wang, Yue, and Battié, Michele C
- Subjects
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LUMBAR vertebrae diseases , *LUMBAR vertebrae abnormalities , *MAGNETIC resonance imaging , *DEGENERATION (Pathology) , *INTERVERTEBRAL disk - Abstract
Study Design: A cross-sectional magnetic resonance (MR) imaging study.Objective: To classify and characterize endplate defects using routine lumbar MR images and to determine associations of endplate defects with Modic changes (MCs) and disc degeneration.Summary Of Background Data: Previously, a cadaveric study revealed that endplate lesions were common and associated with back pain history. New in vivo approaches appropriate for clinical studies are needed to further this potentially important line of research on the clinical significance of endplate lesions, including their relation with MCs, disc degeneration, and back pain.Methods: Using a MRI archive, 1564 endplates of 133 subjects (59 men and 74 women, mean age 58.9 ± 11.9 years) with the presence of MCs were retrospectively collected from April of 2014 to June of 2015. On the basis of morphological characteristics, a protocol was proposed to identify three distinct types of endplate defects, including focal, corner, and erosive defects. The location, size, and distribution patterns of various endplate lesions were characterized. MCs and disc degeneration were measured to examine their associations with endplate defects.Results: Endplate defects were observed in 27.8% of endplates studied. Greater age was associated with the presence of endplate defects. Focal defects were the most common (13.5%), followed by erosive defects (11.1%) and corner defects (3.2%). Defect types also differed in size and distribution patterns. Endplate defects and MCs had similar distribution patterns in the lumbar spine. The presence of endplate defects were associated with the presence of MCs (odds ratio = 4.29, P < 0.001), and associated with less disc signal intensity and disc height, and greater disc bulging (P < 0.05).Conclusion: The three endplate defects identified on routine MR images appear to represent different pathologies and may play a key role in the pathogenesis of MCs. This classification system may facilitate clinical studies on endplate defects.Level Of Evidence: 4. [ABSTRACT FROM AUTHOR]- Published
- 2018
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5. Vertebral Augmentation can Induce Early Signs of Degeneration in the Adjacent Intervertebral Disc: Evidence from a Rabbit Model.
- Author
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Zhiyun Feng, Lunhao Chen, Xiaojian Hu, Ge Yang, Zhong Chen, Yue Wang, Feng, Zhiyun, Chen, Lunhao, Hu, Xiaojian, Yang, Ge, Chen, Zhong, and Wang, Yue
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INTERVERTEBRAL disk , *MAGNETIC resonance imaging , *LUMBAR vertebrae , *NUCLEUS pulposus , *CARTILAGE cells , *INTERVERTEBRAL disk surgery , *POLYMETHYLMETHACRYLATE , *ANIMAL experimentation , *APOPTOSIS , *BIOLOGICAL models , *SPINE diseases , *RABBITS , *THERAPEUTICS - Abstract
Study Design: An experimental study.Objective: The aim of this study was to determine the effect of polymethylmethacrylate (PMMA) augmentation on the adjacent disc.Summary Of Background Data: Vertebral augmentation with PMMA reportedly may predispose the adjacent vertebra to fracture. The influence of PMMA augmentation on the adjacent disc, however, remains unclear.Methods: Using a retroperitoneal approach, PMMA augmentation was performed for 23 rabbits. For each animal, at least one vertebra was augmented with 0.2 to 0.3 mL PMMA. The disc adjacent to the augmented vertebra and a proximal control disc were studied using magnetic resonance (MR) imaging, histological and molecular level evaluation at 1, 3, and 6 months postoperatively. Marrow contact channels in the endplate were quantified in histological slices and number of invalid channels (those without erythrocytes inside) was rated. Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) was performed to determine disc cell apoptosis.Results: On MR images, the signal and height of the adjacent disc did not change 6 months after vertebral augmentation. Histological scores of the adjacent disc increased over time, particularly for the nucleus pulposus. The adjacent disc had greater nucleus degeneration score than the control disc at 3 months (5.7 vs. 4.5, P < 0.01) and 6 months (6.9 vs. 4.4, P < 0.001). There were more invalid marrow contact channels in the endplate of augmented vertebra than the control (43.3% vs. 11.1%, P < 0.01). mRNA of ADAMTS-5, MMP-13, HIF-1α, and caspase-3 were significantly upregulated in the adjacent disc at 3 and 6 months (P < 0.05 for all). In addition, there were more TUNEL-positive cells in the adjacent disc than in the control disc (43.4% vs. 24.0%, P < 0.05) at 6 months postoperatively.Conclusion: Vertebral augmentation can induce early degenerative signs in the adjacent disc, which may be due to impaired nutrient supply to the disc.Level Of Evidence: N/A. [ABSTRACT FROM AUTHOR]- Published
- 2018
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6. Type II Modic Changes May not Always Represent Fat Degeneration: A Study Using MR Fat Suppression Sequence.
- Author
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Zhiyun Feng, Yuanhao Liu, Wei Wei, Shengping Hu, Yue Wang, Feng, Zhiyun, Liu, Yuanhao, Wei, Wei, Hu, Shengping, and Wang, Yue
- Subjects
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FATTY degeneration , *LUMBAR vertebrae , *MAGNETIC resonance imaging , *IMAGE analysis , *LOGISTIC regression analysis - Abstract
Study Design: A radiological study of type II Modic changes (MCs).Objectives: The aim of this study was to determine the characteristics of type II MCs on fat suppression (FS) magnetic resonance (MR) images and its association with radiological disc degeneration.Summary Of Background Data: Type II MCs are common endplate signal changes on MR images. On the basis of limited histological samples, type II MCs are thought to be stable fat degeneration. FS technique on MR, which can quantify fat content, may be an alternative to explore the pathology of MCs. To date, however, the characteristics of type II MCs on FS sequence have not been studied.Methods: Lumbar MR images conducted in a single hospital during a defined period were reviewed to include those with type II MCs and FS images. On FS images, signal status of type II MCs was visually classified as suppressed or not-suppressed. Signal intensity of vertebral regions with and without MCs was measured quantitatively on T2-weighted (T2W) and FS images to calculate fat content index and validate the visual classification. Using image analysis program Osirix, MCs size and adjacent disc degeneration were measured quantitatively. Paired t-tests and logistic regressions were used to determine the associations studied.Results: Sixty-four lumbar MRIs were included and 150 endplates with type II MCs were studied. Although signal of 37 (24.7%) type II MCs was suppressed on FS images, that of 113 (75.3%) was not suppressed. The discs adjacent to type II MCs had lower signal intensity (0.13 ± 0.003 vs. 0.14 ± 0.004, P < 0.001), lesser disc height (9.73 ± 1.97 vs. 11.07 ± 1.99, P < 0.001) and greater bulging area (80.0 ± 31.4 vs. 61.3 ± 27.5 for anterior bulging, 33.72 ± 21.24 vs. 27.93 ± 12.79 for posterior bulging, and 113.7 ± 39.9 vs. 89.2 ± 35.2 for total bulging, P < 0.05) than normal controls. Type II MCs that were not suppressed on FS image were associated with greater age [odds ratio (OR) = 1.11, P < 0.001], lower height (OR = 0.94, P < 0.05), and greater posterior bulging (OR = 1.05, P < 0.001) at the adjacent disc.Conclusion: Signal of most type II MCs was not suppressed on FS MR images, suggesting that there are ongoing complicated pathologies. Type II MCs may not merely represent fat replacement.Level Of Evidence: 3. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
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