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Start Over Author "Polizzi, Nicolò" Topic disaster victims
2 results on '"Polizzi, Nicolò"'

1. Disaster victim identification by kinship analysis: the Lampedusa October 3rd, 2013 shipwreck.

Author

Bertoglio B, Grignani P, Di Simone P, Polizzi N, De Angelis D, Cattaneo C, Iadicicco A, Fattorini P, Presciuttini S, and Previderè C

Subjects
Accidents, Chromosomes, Human, Y, DNA, Mitochondrial genetics, Disasters, Gene Frequency, Humans, Microsatellite Repeats, Ships, Transients and Migrants, DNA Fingerprinting methods, Disaster Victims, Forensic Genetics methods, Pedigree
Abstract

On October 3rd, 2013 a boat carrying more than 500 migrants coming mostly from the Horn of Africa (Eritrea, Somalia, Ethiopia) sank near Lampedusa, a small Italian Island in the middle of the Mediterranean Sea. The recovered bodies were examined by a forensic team, and post mortem data (anthropological and odontological records, and DNA) were collected for identification. Genetic profiles based on 16 autosomal STRs were acquired from both victims and putative relatives recruited following an international call. The final genetic database included 363 victims and 43 reference persons from 36 independent families recruited until mid-2017, who were missing 35 first-degree and 6 second-degree relatives. A pairwise blind search approach was used to identify familial relationships within the victims and between victims and putative relatives. Two statistics were calculated, the Identity by State (IBS) and the Identity by Descent (IBD), the latter by using the DVI module of the FAMILIAS3 software to compute LRs and posterior probabilities. The putative identifications were confirmed in pedigree analysis using the information provided by the relatives. In selected cases, additional autosomal and lineage (Y-chromosome and mtDNA) markers were typed. Some critical points were highlighted: the lack for accurate allele and haplotype frequencies in African populations, especially for the lineage markers, and the need for a shared approach to the biostatistical interpretation of the results in DVI. In the end, 29 first-degree (parent-child and full sibs) out of 35 missing (83%), and 3 out of 6 of second-degree relatives (50%) showed a high statistical confidence for a positive identification. This study represents the first attempt to systematically deal with the genetic identification of African migrants who died in the Mediterranean Sea. The methodological and statistical approach used in this study was proved to be reliable and appropriate for future genetic identifications in other similar mass disasters., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Published
2020
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2. Disaster victim identification by kinship analysis: the Lampedusa October 3rd, 2013 shipwreck

Author

Carlo Previderè, Nicolò Polizzi, Agata Iadicicco, Paolo Fattorini, D. De Angelis, Pierangela Grignani, Paola Di Simone, Barbara Bertoglio, Cristina Cattaneo, Silvano Presciuttini, Bertoglio, Barbara, Grignani, Pierangela, Di Simone, Paola, Polizzi, Nicolò, De Angelis, Danilo, Cattaneo, Cristina, Iadicicco, Agata, Fattorini, Paolo, Presciuttini, Silvano, and Previderè, Carlo

Subjects
Forensic Genetics, 0301 basic medicine, Lineage (genetic), Kinship analysis, FAMILIAS, STR, DNA, Mitochondrial, Migrants, Identity by descent, Identity by state, Pathology and Forensic Medicine, Disasters, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, Genetics, Kinship, Humans, DVI, Genetic identification, 030216 legal & forensic medicine, Lampedusa, Ships, Transients and Migrants, Chromosomes, Human, Y, biology, Haplotype, Migrant, Disaster victim identification, biology.organism_classification, DNA Fingerprinting, Genealogy, Pedigree, 030104 developmental biology, Geography, Accidents, Kinship analysi, Identification (biology), Disaster Victims, Microsatellite Repeats
Abstract

On October 3rd, 2013 a boat carrying more than 500 migrants coming mostly from the Horn of Africa (Eritrea, Somalia, Ethiopia) sank near Lampedusa, a small Italian Island in the middle of the Mediterranean Sea. The recovered bodies were examined by a forensic team, and post mortem data (anthropological and odontological records, and DNA) were collected for identification. Genetic profiles based on 16 autosomal STRs were acquired from both victims and putative relatives recruited following an international call. The final genetic database included 363 victims and 43 reference persons from 36 independent families recruited until mid-2017, who were missing 35 first-degree and 6 second-degree relatives. A pairwise blind search approach was used to identify familial relationships within the victims and between victims and putative relatives. Two statistics were calculated, the Identity by State (IBS) and the Identity by Descent (IBD), the latter by using the DVI module of the FAMILIAS3 software to compute LRs and posterior probabilities. The putative identifications were confirmed in pedigree analysis using the information provided by the relatives. In selected cases, additional autosomal and lineage (Y-chromosome and mtDNA) markers were typed. Some critical points were highlighted: the lack for accurate allele and haplotype frequencies in African populations, especially for the lineage markers, and the need for a shared approach to the biostatistical interpretation of the results in DVI. In the end, 29 first-degree (parent-child and full sibs) out of 35 missing (83%), and 3 out of 6 of second-degree relatives (50%) showed a high statistical confidence for a positive identification. This study represents the first attempt to systematically deal with the genetic identification of African migrants who died in the Mediterranean Sea. The methodological and statistical approach used in this study was proved to be reliable and appropriate for future genetic identifications in other similar mass disasters.

Published
2020

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