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In this article, we report the identification of a new HLA-A allele found in a DNA sample which was part of the routine bone marrow donor typing performed in our laboratory. This novel allele officially designated as A*2442 was found in a sample from a female Caucasoid donor (Franken, Bavaria, Germany; lab code 142654) and differs from the closest related allele A*2408 by two nucleotide exchanges. In position 81, the A (A*2408) is changed to 81 C in the novel allele A*2442, resulting in an amino acid substitution at codon 27, glutamine (A*2408) is replaced by histidine (31Gln→31His). In position 292, the G (A*2408) is changed to C also resulting in an amino acid replacement, the codon 98 asparagine is mutated to histidine (98Asn→98His) in the new A*2442 allele. The second allele was determined to be A*0301. Further typing of this sample is B*1501 B*4001. [ABSTRACT FROM AUTHOR]

In this paper, we report the identification of a new human leucocyte antigen-B (HLA-B) allele in a sample which has participated in a search for unrelated bone marrow donors which was initiated by the Aktion Knochenmarkspende Bayern. This novel allele officially designed B*4046 was detected by different low-resolution sequence-specific oligonucleotide typings not matching to known allele combinations in a female Caucasoid individual. Confirming the presence of a novel allele by sequence-based typing, the closest-related allele B*400103 differs from the new B*4046 allele by three mutations. This results in an amino acid substitution from threonine to alanine in B*4046 at codon 65, while codon 68 remains conserved and codon 69 ‘AAG’ lysine is replaced by ‘GAG’ glutamic acid in B*4046. [ABSTRACT FROM AUTHOR]

The article focuses on the identification of a novel human leukocyte antigen (HLA-DRBI) allele in a female patient who is about to have her bone marrow transplantation. The said HLA-DRBI has been analyzed through the sequence-specific primers but was not able to show a clear typing result. The performance of the sequence-based typing, however, did not also match with any allele combination. The matching of allele combination resulted only through the use of the single amino acid exchange.

In this article, we report the identification of a new human leukocyte antigen-B allele in a sample that was tested in our routine typing for volunteer bone marrow donors. This novel allele officially designed B*5517 was found in a male donor of Bavarian Caucasoid origin (Laboratory code 150113). The search for unrelated bone marrow donors was initiated by the Aktion Knochenmark-spende Bayern. In comparison with the common B*5501 allele, B*5517 differs at three nucleotide positions all located in exon 3, at position 379 (C→G), 419 (T→A), and 420 (A→C), resulting in two amino acid substitutions at codons 127 and 140. The amino acid 127, leucine, is changed to valine, and the amino acid 140, also a leucine, is replaced by tyrosine in B*5517. [ABSTRACT FROM AUTHOR]

In this study, we report the identification of a new human leucocyte antigen-B (HLA-B) allele in a sample that was found in our routine typing. This novel allele, officially designed HLA-B*5514, was found in a male donor of Bavarian Caucasoid origin (Laboratory code: 117562) typed in order for a request of the bone marrow donor registry Aktion Knochenmarkspende Bayern. Although this novel allele was added to the HLA-B*55 family by the Nomenclature Committee, the next related alleles were found in the HLA-B*56 group; HLA-B*5612 differing in six positions from HLA-B*5514 is the closest related allele. [ABSTRACT FROM AUTHOR]

In this report we describe the identification of a novel HLA-DPB1 allele, DPB1*9601, found in a Caucasian individual sample named ucla#356. The new allele was detected in the DNA of ucla#356 during routine HLA sequence-based typing (SBT) of samples participating in the UCLA International HLA DNA Exchange (number 55) for HLA DNA Proficiency Testing. DPB1*9601 was identical to DPB1*3901 except for a single nucleotide substitution ‘G’→‘C’ in previously constant position 277 (position 177, respectively, counting only exon 2). This nucleotide change causes an amino acid substitution from aspartic acid in DPB1*3901 to histidine at codon 64 in the novel allele. This new allele has been submitted to the EMBL database and has been assigned the accession number AJ514871. The WHO Nomenclature Committee has officially assigned the name DPB1*9601. [ABSTRACT FROM AUTHOR]

In this paper we report the identification of a new HLA- Cw*03 allele in a sample that has been distributed in the International UCLA Terasaki Cell/DNA Exchange. This novel allele officially designed Cw*03033 and renumbered to Cw*030303 (2) found in cell no. 1054 from an Asian Indian donor differs from Cw*030301 by a silent substitution at codon 128, GGG→GGA (nucleotide position 384). This new allelic variant was confirmed by several other laboratories participating in the UCLA Terasaki Cell/DNA Exchange (3). [ABSTRACT FROM AUTHOR]

In this study, we report the identification of HLA-B*1314 that differs from B*130201 at two single nucleotide positions. [ABSTRACT FROM AUTHOR]

In this paper we report the identification of human leukocyte antigen (HLA)-DQB1*0628 and the confirmation of HLA-DQB1*060302. [ABSTRACT FROM AUTHOR]

The article cites a study which identifies the new human leukocyte antigen B allele among volunteer bone marrow donors. Based on a study, a novel allele named B*2734 has been found in a female donor who originated from Caucasoid. The objective of the study is to compare the nucleotide positions of the two closest related allele, the B*2707 and B*2734. These two alleles are said to be located in exon 3, position 412.

In this report, we describe the identification of a novel human leukocyte antigen-A*24 (HLA-A*24) allele, designated HLA-A*2467. The new allele differs from the most closely related allele HLA-A*2408 at five nucleotide positions all located in exon 2. Four of the five nucleotide changes result in amino acid substitution. [ABSTRACT FROM AUTHOR]