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Your search keyword '"Szladovits, B."' showing total 2 results
Start Over Author "Szladovits, B." Topic direct antiglobulin test
2 results on '"Szladovits, B."'

1. Demographic Characteristics, Survival and Prognostic Factors for Mortality in Cats with Primary Immune-Mediated Hemolytic Anemia.

Author

Swann, J.W., Szladovits, B., and Glanemann, B.

Subjects
*CAT diseases, *PET death, *HEMOLYTIC anemia, *EPITHELIAL cells, *ACQUISITION of data, *DISEASE risk factors
Abstract

Background Immune-mediated hemolytic anemia ( IMHA) is uncommon in cats, but may result in severe disease. Demographic predispositions for development of the disease and prognostic factors for mortality have not been investigated previously. Hypothesis/Objectives To explore possible demographic predispositions for development of primary IMHA in cats and to investigate possible prognostic factors for mortality. Animals 107 client-owned cats with IMHA, of which 72 had primary IMHA and 35 had secondary IMHA, and 9,194 control cats. Methods Data were collected retrospectively from records of cats with IMHA, defined by the presence of anemia and concurrent autoagglutination, ghost cells without oxidative damage on fresh blood smear, positive titer in a direct antiglobulin test, or evidence of phagocytosis of erythroid precursors in bone marrow. Odds ratios were calculated to assess the risk of development of primary IMHA in different demographic groups and Cox proportional hazards analysis was conducted to evaluate prognostic factors. Results No sex or breed predisposition was identified for the development of primary IMHA in comparison to the control cats, but cats in the age range 2.1-5.9 years were predisposed. Higher total bilirubin concentration and age were significant negative prognostic factors and higher lymphocyte numbers and serum globulin concentration were positive prognostic factors in a multivariable model. Conclusions and Clinical Importance Young adult cats were more likely to develop primary IMHA than other groups, but no apparent male predisposition was identified in this study, contrary to previous reports. Several prognostic factors were identified, which may be helpful in guiding clinical practice in the future. [ABSTRACT FROM AUTHOR]

Published
2016
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2. ACVIM consensus statement on the diagnosis of immune-mediated hemolytic anemia in dogs and cats

Author

George Lubas, Saralyn Smith-Carr, Robert Goggs, Jonathan E. Fogle, Balazs Szladovits, Dana N. LeVine, Angela M. Mexas, Linda Kidd, Barbara Glanemann, Unity Jeffery, James W. Swann, Jennifer L. Granick, Julien R.S. Dandrieux, Simona Buoncompagni, Amy L. MacNeill, Adam J. Birkenheuer, Yu-Mei Chang, Antonio Di Loria, Oliver A. Garden, Shauna L. Blois, Claire R. Sharp, Claire L. Fellman, Garden, O. A., Kidd, L., Mexas, A. M., Chang, Y. -M., Jeffery, U., Blois, S. L., Fogle, J. E., Macneill, A. L., Lubas, G., Birkenheuer, A., Buoncompagni, S., Dandrieux, J. R. S., Di Loria, A., Fellman, C. L., Glanemann, B., Goggs, R., Granick, J. L., Levine, D. N., Sharp, C. R., Smith-Carr, S., Swann, J. W., and Szladovits, B.

Subjects
Hemolytic anemia, medicine.medical_specialty, Consensus, 040301 veterinary sciences, Anemia, spherocyte, 030204 cardiovascular system & hematology, direct antiglobulin test, Cat Diseases, 0403 veterinary science, Small Animal, comorbidity, Delphi survey, direct antiglobulin test, erythrocyte, evidence, flow cytometry, hemolysis, iceberg model, spherocyte, veterinary and comparative clinical immunology society, 03 medical and health sciences, 0302 clinical medicine, Dogs, Dog, medicine, veterinary and comparative clinical immunology society, Animals, Dog Diseases, hemolysi, Intensive care medicine, iceberg model, Immune mediated hemolytic anemia, CATS, General Veterinary, Animal, Task force, business.industry, Societies, Veterinary, evidence, flow cytometry, Consensus Statements, Consensus Statement, Cat, 04 agricultural and veterinary sciences, Cat Disease, medicine.disease, Causality, Comorbidity, Evidence quality, comorbidity, Cats, Delphi survey, Anemia, Hemolytic, Autoimmune, erythrocyte, Dog Disease, hemolysis, business
Abstract

Immune-mediated hemolytic anemia (IMHA) is an important cause of morbidity and mortality in dogs. IMHA also occurs in cats, although less commonly. IMHA is considered secondary when it can be attributed to an underlying disease, and as primary (idiopathic) if no cause is found. Eliminating diseases that cause IMHA may attenuate or stop immune-mediated erythrocyte destruction, and adverse consequences of long-term immunosuppressive treatment can be avoided. Infections, cancer, drugs, vaccines, and inflammatory processes may be underlying causes of IMHA. Evidence for these comorbidities has not been systematically evaluated, rendering evidence-based decisions difficult. We identified and extracted data from studies published in the veterinary literature and developed a novel tool for evaluation of evidence quality, using it to assess study design, diagnostic criteria for IMHA, comorbidities, and causality. Succinct evidence summary statements were\ud written, along with screening recommendations. Statements were refined by conducting 3 iterations of Delphi review with panel and task force members. Commentary was solicited from several professional bodies to maximize clinical applicability\ud before the recommendations were submitted. The resulting document is intended to provide clinical guidelines for diagnosis of, and underlying disease screening for, IMHA in dogs and cats. These should be implemented with consideration of animal, owner, and geographical factors.

Published
2019

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