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Grass-based suckling beef-derived foods occasionally exceed regulatory levels for polychlorinated biphenyls (PCBs) and dibenzo-p-dioxins/dibenzofurans (PCDD/Fs). Ensuring chemical safety requires understanding the cow-calf transgenerational PCB and PCDD/F fate. The current focus was on dairy cows, omitting transgenerational fate and suckling beef-related physiological effects. This study aimed to investigate PCB and PCDD/F absorption, distribution, metabolism, and excretion within 12 Simmental cows (six primiparous/six multiparous) and 12 calves fed with the milk of their respective mothers for 109 days prepartum until 288 days in milk (DIM), i.e., slaughter time. Eight cows were exposed to a grass silage-soil mixture. Four were decontaminated after DIM164 by receiving uncontaminated grass silage, which four control cows received. An input-output balance during gestation and lactation was computed from PCB, PCDD/F, and lipid inputs (solid feed/milk intakes), outputs (fecal/milk excretions), and body storage (initial/final burdens). At slaughter, PCB and PCDD/F tissue distribution, and lipid allometry were linked. Apparent PCB and PCDD/F absorption rates and metabolized fractions decreased with increasing chlorination. In calves, PCB absorption showed no effect due to chlorination (steady range: 71-87%). High-chlorinated PCB and PCDD/F absorption rates decreased when provided through soil. Cows excreted PCBs and PCDD/Fs via feces (50% relative to input) and milk (9%) and accumulated only 5% in their body, whereas calves accumulated the largest fraction of the total input in their bodies (44%). Cow physiology affected accumulation and excretion, as in primiparous cows, net body burden and milk assimilation efficiencies were higher and lower, respectively, than in multiparous. Liver-specific enrichment was observed in cows and calves (7.0- and 3.2-fold iPCB and dlPCB + PCDD/F TEQ, compared to empty body-based lipid concentrations), whereas iPCBs were also enriched in kidneys (3.1-fold) and muscles (1.5-fold). Consequently, adipose concentrations did not perfectly represent most edible beef tissues. This highlights the essence of integrating the interplay between physicochemical pollutant properties and animal physiology in transgenerational transfer assessments of PCBs and PCDD/Fs., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Flooding and other sediment disturbances can lead to increases in sediment resuspension. In this context, it is of central importance to understand the kinetics of release from these sediments and the uptake of pollutants, such as polychlorinated biphenyls (PCBs) and polychlorinated dioxins and furans (PCDD/Fs), into aquatic organisms. In the present study, we parameterized a sediment desorption model based on experimentally determined rapidly-desorbing fractions of dioxin-like chemicals (DLCs). We coupled this desorption model with a physiologically-based toxicokinetic model for rainbow trout. This combined model was used to predict DLC concentrations in the muscle of exposed fish. The performance of this model was evaluated using a previously published dataset on DLC uptake from sediment suspensions during simulated re-suspension events. Predictions generally differed less than 10-fold from measured values, and the model showed a good global coefficient of determination (R 2 ) of 0.95. The root mean squared error (RMSE) for PCBs was 0.31 log units and 0.53 log units for PCDD/Fs. The results of our study demonstrate that the prediction of bioconcentration and related risk to fish resulting from sediment resuspension can be accurately predicted using coupled desorption and toxicokinetic models., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Polychlorinated dibenzodioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) summarized as dioxins, as well as polychlorinated biphenyls (PCBs) are persistent, bio-accumulative and toxic environmental contaminants. Over 95% of human exposure to these problematic chemicals occurs via the ingestion of fatty rich food like meat and meat products, fatty fish, as well as milk and dairy products. Several major food and feed contamination incidents in Europe during the years 1997 and 2010 revealed the necessity of establishing food and feed monitoring programs for dioxins and PCBs. Various monitoring programs carried out by the Federal Office of Public Health (FOPH) and the Federal Food Safety and Veterinary Office (FSVO), suggest that cattle from extensive farming (suckler cow husbandry) exhibited higher levels of dioxin-like PCBs (dl-PCBs) and exceeded with higher frequency the permitted maximum levels (ML) when compared to conventional raised cattle. The reasons for the higher levels are possibly due to higher levels of PCBs in green fodder (pasture, silage, and hay) when compared to the concentrated feed used in conventional farming. Additionally, an increased uptake of soil, which is known to be a risk matrix for the uptake of dioxins and PCBs in grazing animals, leads to elevated contaminant levels in the suckler cows and hence their calves. Furthermore, PCB point sources present on a farm from older building and construction materials ( e.g. PCB-containing wall paints) might result in very high contamination of the animals and the meat produced from them.

We report on two farms in Switzerland heavily contaminated by polychlorinated biphenyls (PCBs) and dioxins (PCDD/Fs), occurring in the first case from diffuse sources and in the second case from PCB-containing wall paint. Extensive measurements of PCBs and PCDD/Fs on site (soil, forage, and paint) and in cattle (blood, fat, and milk) allowed validation of our novel dynamic toxicokinetic model, which includes the transfer of contaminants from the mother cows to their suckling calf and the uptake of soil by grazing cattle. We show that for calves, the mother milk is the main uptake route of contaminants. For both cows and calves, ingestion of contaminated soil, although often overlooked, is an appreciable uptake path. The remediation of the contaminated stable lead to a 2-3 fold reduction of the PCB levels in animals within one year. The transfer of animals to an uncontaminated mountain site during summer proved to be an effective decontamination procedure with up to 50% reduction of the levels within three months. Our study calls for a rapid removal of PCB-containing materials in animal husbandry farms and shows that the diffuse contamination of soils will remain a source for PCBs and PCDD/Fs in our food chain for decades to come.

The increasing volumes of waste electrical and electronic equipment (WEEE) in Europe and developing economies demand for efficient disposal solutions. However, WEEE also contains toxic compounds and, therefore, there is a need for recycling technologies for WEEE that creates revenue without causing environmental harm. Among other fast developing economies, South Africa is tempting to make use of recycled plastic. Brominated flame retardants (BFRs) are additives used to protect plastic materials in electrical and electronic equipment (EEE) against ignition. Some BFRs are known persistent organic pollutants (POPs) and some BFRs can be transformed into highly toxic compounds such as polybrominated dibenzofurans and dioxins (PBDD/Fs). In this study, the contents of critical BFRs, i.e. polybrominated diphenyl ethers, and highly toxic PBDD/Fs were measured in WEEE material from Switzerland and South Africa. The formation of PBDD/Fs has been observed in two South African recycling processes and under controlled laboratory conditions. Total PBDE-contents in the South African and Swiss plastic waste varied between 1×10(3) and 7×10(6) μg kg(-1). A few WEEE plastic fractions exceeded the RoHS limit of 1×10(6) μg kg(-1) for PBDEs and thus they could not be used for recycling products without special treatment. The total content of ∑PBDFs was around 1×10(3) μg kg(-1). Such contents in materials do not pose a risk for consumer under normal conditions. Workers at recycling plants might be at risk. The measured formation rates of PBDFs were between 2×10(-5) and 2×10(-4)∑PBDE(-1) min(-1)., (Copyright © 2014 Elsevier Ltd. All rights reserved.)

The article focuses on a study which monitored 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Ukranian presidential candidate Viktor Yushchenko after he presented with severe poisoning. Using gas chromatography and high resolution mass spectrometry, TCDD and its metabolites were identified and monitored for three years in samples from Yuschenko's blood serum, adipose tissue, faeces, skin, urine and sweat, after they were extracted and cleaned with different organic solvents. The researchers accounted about 60% of unmodified TCDD eliminated from the body during the three-year period. Findings of the study suggested that the design methods for routine assessment of TCDD metabolites in human beings should be a main aim of TCDD research in metabolomic era.