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Your search keyword '"Levodopa chemical synthesis"' showing total 2 results
Start Over Descriptor "Levodopa chemical synthesis" Topic dihydroxyphenylalanine
2 results on '"Levodopa chemical synthesis"'

1. Synthesis of no-carrier-added L- and D-[1-11C]-DOPA.

Author

Bolster JM, Vaalburg W, Van Veen W, Van Dijk T, Van der Molen HD, Wynberg H, and Woldring MG

Subjects
Brain diagnostic imaging, Brain metabolism, Humans, Isotope Labeling methods, Neoplasms diagnostic imaging, Radionuclide Imaging, Dihydroxyphenylalanine chemical synthesis, Levodopa chemical synthesis
Abstract

No-carrier-added DL-[1-11C]-DOPA has been synthesized by carboxylation of an alpha-lithioisocyanide with a radiochemical yield of up to 15% without correction for decay. The total synthesis time is 30 min. The resolution of the D- and L-isomers was accomplished within 16 min by HPLC using a chiral stationary phase and a phosphate buffer of pH 4.5 as eluent.

Published
1983
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2. Aromatic radiofluorination with [18F]fluorine gas: 6-[18F]fluoro-L-dopa.

Author

Firnau G, Chirakal R, and Garnett ES

Subjects
Chromatography, High Pressure Liquid, Dihydroxyphenylalanine chemical synthesis, Isotope Labeling, Magnetic Resonance Spectroscopy, Dihydroxyphenylalanine analogs & derivatives, Fluorine, Levodopa chemical synthesis, Radioisotopes
Abstract

A new synthesis is described for the routine production of 3,4-dihydroxy-6-[18F]fluoro-phenyl-L-alanine (6-[18F]fluoro-L-dopa). The reaction between [18F]fluorine gas and 3,4-dihydroxyphenyl-L-alanine (L-dopa) in liquid hydrogen fluoride gave 2-, 5-, and 6-[18F]fluoro-L-dopa. 6-[18F]Fluoro-L-dopa was isolated by reverse-phase high-pressure liquid chromatography. From 100 mCi [18F]F2, the method produces 3 mCi of 6-[18F]fluoro-L-dopa at the end of synthesis.

Published
1984

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