1. Acromegaly and vitamin D metabolism: effect of bromocriptine treatment.
- Author
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Eskildsen PC, Lund B, Sørensen OH, Lund B, Bishop JE, and Norman AW
- Subjects
- Acromegaly drug therapy, Adult, Aged, Calcium metabolism, Growth Hormone urine, Humans, Middle Aged, Prolactin blood, Acromegaly blood, Bromocriptine therapeutic use, Dihydroxycholecalciferols blood, Hydroxycholecalciferols blood
- Abstract
Fifteen acromegalic subjects were found to have elevated plasma levels of both 1,25(OH)2-vitamin D, 65 +/- 23 (SD) pg/ml [normal 33 + 15 pg/ml (SD)] and 24,25(OH)2-vitamin D, 6.8 +/- 1.6 (SD) ng/ml [normal 3.4 + 1.2 ng/ml (SD)]. Treatment with bromocriptine for 6 months reduced the plasma 1,25(OH)2-vitamin D3 level to 40 +/- 13 (SD) pg/ml, p less than 0.01 and the 24,25(OH)2-vitamin D level to 5.4 +/- 1.7 (SD) ng/ml, p less than 0.05.
- Published
- 1979
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