1. Cellular antioxidant activity and in vitro inhibition of α-glucosidase, α-amylase and pancreatic lipase of oregano polyphenols under simulated gastrointestinal digestion.
- Author
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Gutiérrez-Grijalva EP, Antunes-Ricardo M, Acosta-Estrada BA, Gutiérrez-Uribe JA, and Basilio Heredia J
- Subjects
- Antioxidants isolation & purification, Caco-2 Cells, Chromatography, High Pressure Liquid, Gastric Acid chemistry, Glycoside Hydrolase Inhibitors isolation & purification, Humans, Hypolipidemic Agents isolation & purification, Intestinal Secretions chemistry, Lipase metabolism, Oxidation-Reduction, Oxidative Stress drug effects, Plant Extracts isolation & purification, Polyphenols isolation & purification, Spectrometry, Mass, Electrospray Ionization, Antioxidants pharmacology, Digestion, Glycoside Hydrolase Inhibitors pharmacology, Hypolipidemic Agents pharmacology, Lipase antagonists & inhibitors, Origanum chemistry, Plant Extracts pharmacology, Polyphenols pharmacology
- Abstract
Different oregano species have been traditionally used as infusions in folk medicine. Oregano medicinal properties, such as antioxidant and anti-inflammatory, have been partially attributed to its polyphenolic content. However, information regarding bioaccessibility of oregano polyphenols is limited. Cell-based antioxidant activity, and in vitro hypoglycemic, and hypolipidemic properties of polyphenolic extracts from three species of oregano species, namely, Hedeoma patens (HP), Lippia graveolens (LG) and Lippia palmeri (LP), subjected to simulated gastrointestinal digestion were evaluated. LC-TOF-MS analysis of HP, LG and LP allowed the identification of 9 flavonoids and 6 hydroxycinnamic acid derivatives with nutraceutical significance. Oregano polyphenolic extracts and digests from HP, LG, and LP exhibited cellular antioxidant capacity, hypoglycemic and hypolipidemic properties. Altogether, our results suggest that HP, LG and LP polyphenols exhibit potential for use as hypoglycemic, hypolipidemic, and antioxidant agents., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Published
- 2019
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