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Objectives: Cerebral blood flow (CBF) measurements after endovascular therapy (EVT) for acute ischemic stroke are important to distinguish early secondary injury related to persisting ischemia from that related to reperfusion when considering clinical response and infarct growth., Methods: We compare reperfusion quantified by the modified Thrombolysis in Cerebral Infarction Score (mTICI) with perfusion measured by MRI dynamic contrast-enhanced perfusion within 5 h of EVT anterior circulation stroke. MR perfusion (rCBF, rCBV, rTmax, rT0) and mTICI scores were included in a predictive model for change in NIHSS at 24 h and diffusion-weighted imaging (DWI) lesion growth (acute to 24 h MRI) using a machine learning RRELIEFF feature selection coupled with a support vector regression., Results: For all perfusion parameters, mean values within the acute infarct for the TICI-2b group (considered clinically good reperfusion) were not significantly different from those in the mTICI <2b (clinically poor reperfusion). However, there was a statistically significant difference in perfusion values within the acute infarct region of interest between the mTICI-3 group versus both mTICI-2b and <2b ( p = 0.02 ). The features that made up the best predictive model for change in NIHSS and absolute DWI lesion volume change was rT0 within acute infarct ROI and admission CTA collaterals respectively. No other variables, including mTICI scores, were selected for these best models. The correlation coefficients (Root mean squared error) for the cross-validation were 0.47 (13.7) and 0.51 (5.7) for change in NIHSS and absolute DWI lesion volume change., Conclusion: MR perfusion following EVT provides accurate physiological approach to understanding the relationship of CBF, clinical outcome, and DWI growth., Advances in Knowledge: MR perfusion CBF acquired is a robust, objective reperfusion measurement providing following recanalization of the target occlusion which is critical to distinguish potential therapeutic harm from the failed technical success of EVT as well as improve the responsiveness of clinical trial outcomes to disease modification.

This document is a collection of abstracts from the Journal of Neonatal - Perinatal Medicine. The abstracts cover various topics related to neonatal neurodevelopment and brain abnormalities in preterm infants. One study focuses on the use of MRI in predicting long-term outcomes in infants with Hypoxic Ischemic Encephalopathy. Another study explores the prediction of post-hemorrhagic ventricular dilatation in preterm infants with intraventricular hemorrhage. A third study examines the impact of cerebellar hemorrhage on the neurodevelopmental outcomes of extremely preterm infants. The fourth abstract compares the utility of early and late MRI in evaluating infants with Neonatal Encephalopathy. Additionally, there is a study investigating the impact of SARS-CoV-2 infection during pregnancy on neonatal neurological outcomes. Lastly, a study explores the hemodynamic responses associated with spontaneous neural activity in the early developing brain. These abstracts provide valuable insights into neonatal neurodevelopment and brain abnormalities in preterm infants. [Extracted from the article]