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Your search keyword '"Udodov, V. D."' showing total 1 results
Start Over Author "Udodov, V. D." Topic differential diagnosis
1 results on '"Udodov, V. D."'

1. Radiolabeled Complex of Antimicrobial Peptides UBI29-41 and UBI18-35 Labeled with 99mTc for Differential Diagnosis of Bone Infection of the Limbs.

Author

Zavadovskaya, V. D., Larkina, M. S., Stasyuk, E. S., Zorkaltsev, M. A., Udodov, V. D., Ivanov, V. V., Shevtsova, N. M., Rogov, A. S., Lushchyk, A. Ya., Yantsevich, A. V., Belousov, M. V., Baikov, A. N., Skuridin, V. S., and Pershina, A. G.

Subjects
ANTIMICROBIAL peptides, SINGLE-photon emission computed tomography, DIFFERENTIAL diagnosis, RADIOCHEMICAL purification, CHELATING agents, LABELS, SONICATION
Abstract

We studied an original radiolabeled complex of antimicrobial peptides UBI29-41 and UBI18-35, ubiquicidin derivatives, for distinguishing between bacterial and aseptic inflammation. For radiolabeling of the peptides with technetium-99m, a bifunctional chelating agent succinimide-1-yl 6-(bis(pyridin-2-ylmethyl)amino)hexanoate was used. The obtained complexes 99mТс-DPAH-UBI29-41 and 99mТс-DPAH-UBI18-35 had radiolabeling yield >80% and radiochemical purity >96%. Accumulation of the complexes in the focus of bacterial inflammation in bone structures and the absence of this complex in the site of aseptic inflammation was confirmed in a rat model of traumatic osteomyelitis by single-photon emission computed tomography. [ABSTRACT FROM AUTHOR]

Published
2021
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