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Coronavirus disease 2019 (COVID-19) has been declared a global pandemic for more than two years. People who are confirmed positive for COVID-19 or had close contact with COVID-19 patients are suggested to selfisolate to prevent the transmission. Some medications and supplements are recommended to be taken during selfisolation. The aim of the study was to investigate the public knowledge and attitude towards medications and dietary supplements used during COVID-19 self-isolation such as paracetamol, vitamin C, vitamin D, zinc, and antiretroviral favipiravir. A survey of 380 participants in Surabaya, Indonesia using a self-developed questionnaire carried out online using Google form was conducted. The results showed that most participants had good knowledge (80.3%) and a positive attitude (89.5%). Furthermore, the good public knowledge about medications and dietary supplements used in COVID-19 self-isolation was correlated with a positive attitude (p=0.029). Therefore, continuous education and information campaign about medications and dietary supplements used during COVID-19 self-isolation which involving related parties is still needed. [ABSTRACT FROM AUTHOR]