1. In Vitro and In Vivo Anti-inflammatory Activity of Bovine Milkfat Globule (MFGM)-derived Complex Lipid Fractions.
- Author
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Palmano KP, MacGibbon AKH, Gunn CA, and Schollum LM
- Subjects
- Animals, Arthritis metabolism, Cells, Cultured, Cyclooxygenase 2 metabolism, Disease Models, Animal, Edema therapy, Interleukin-1beta metabolism, Leukocyte Elastase metabolism, Lipid Droplets, Monocytes metabolism, Neutrophils metabolism, Nitric Oxide metabolism, Superoxides metabolism, Anti-Inflammatory Agents, Arthritis therapy, Dietary Supplements, Glycolipids administration & dosage, Glycolipids pharmacology, Glycoproteins administration & dosage, Glycoproteins pharmacology, Inflammation Mediators metabolism, Nutritional Physiological Phenomena physiology
- Abstract
Numerous health related properties have been reported for bovine milk fat globule membrane (MFGM) and its components. Here we present novel data on the in vitro and in vivo anti-inflammatory activity of various MFGM preparations which confirm and extend the concept of MFGM as a dietary anti-inflammatory agent. Cell-based assays were used to test the ability of MFGM preparations to modulate levels of the inflammatory mediators IL-1β, nitric oxide, superoxide anion, cyclo-oxygenase-2, and neutrophil elastase. In rat models of arthritis, using MFGM fractions as dietary interventions, the phospholipid-enriched MFGM isolates were effective in reducing adjuvant-induced paw swelling while there was a tendency for the ganglioside-enriched isolate to reduce carrageenan-induced rat paw oedema. These results indicate that the anti-inflammatory activity of MFGM, rather than residing in a single component, is contributed to by an array of components acting in concert against various inflammatory targets. This confirms the potential of MFGM as a nutritional intervention for the mitigation of chronic and acute inflammatory conditions.
- Published
- 2020
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