1. Association between Dietary Inflammatory Index (DII) and risk of prediabetes: a case-control study.
- Author
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Vahid F, Shivappa N, Karamati M, Naeini AJ, Hebert JR, and Davoodi SH
- Subjects
- Case-Control Studies, Developing Countries, Diet ethnology, Diet, Healthy ethnology, Female, Health Transition, Humans, Iran epidemiology, Linear Models, Logistic Models, Male, Middle Aged, Patient Compliance ethnology, Prediabetic State epidemiology, Prediabetic State ethnology, Prediabetic State immunology, Risk Factors, Self Report, Diet adverse effects, Prediabetic State etiology, Urban Health ethnology
- Abstract
The possible relationship between diet-related inflammation and the risk of prediabetes requires further investigation, especially in non-Western populations. We examined the ability of the dietary inflammatory index (DII) to predict the risk of prediabetes in a case-control study conducted at specialized centers in Esfahan, Iran. A total of 214 incident cases of prediabetes were selected with the nonrandom sampling procedure, and the 200 controls randomly selected from the same clinics were frequency-matched on age (±5 years) and sex. DII scores were computed based on dietary intake assessed using a validated and reproducible 168-item food-frequency questionnaire. Linear and logistic regression models were used to estimate multivariable beta estimates and odds ratios (ORs). Subjects in tertile 3 versus tertile 1 (T3VS1) of DII had significantly higher fasting plasma glucose (DII
T3VS1 : b = 4.49; 95% CI 1.89, 7.09), oral glucose tolerance (DIIT3VS1 : b = 8.76; 95% CI 1.78, 15.73), HbA1c (DIIT3VS1 : b = 0.30; 95% CI 0.17, 0.42), low-density lipoprotein (DIIT3VS1 : b = 16.37; 95% CI 11.04, 21.69), triglyceride (DIIT3VS1 : b = 21.01; 95% CI 8.61, 33.42) and body fat (DIIT3VS1 : b = 2.41; 95% CI 0.56, 4.26) and lower high-density lipoprotein (DIIT3VS1 : b = -3.39; 95% CI -5.94, -0.84) and lean body mass (DIIT3VS1 : b = -3.11; 95% CI -4.83, -1.39). After multivariate adjustment, subjects in the most pro-inflammatory DII group had 19 times higher odds of developing prediabetes compared with subjects in tertile 1 (DIIT3VS1 : OR = 18.88; 95% CI 7.02, 50.82). Similar results were observed when DII was used as a continuous variable, (DIIcontinuous : OR = 3.62; 95% CI 2.50, 5.22). Subjects who consumed a more pro-inflammatory diet were at increased risk of prediabetes compared with those who consumed a more anti-inflammatory diet.- Published
- 2017
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