1. Joint Experimental, in Silico, and NMR Studies toward the Rational Design of Iminium-Based Organocatalyst Derived from Renewable Sources.
- Author
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Gerosa, Gabriela G., Spanevello, Rolando A., Suárez, Alejandra G., and Sarotti, Ariel M.
- Subjects
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ORGANOCATALYSIS , *IMINES , *DIELS-Alder reaction , *STRUCTURE-activity relationships , *DENSITY functional theory , *NUCLEAR magnetic resonance , *TRANSITION state theory (Chemistry) - Abstract
An efficient organocatalyst for iminium-ion based asymmetric Diels-Alder (DA) reactions has been rationally designed. The most influential structure-activity relationships were determined experimentally, while DFT calculations and NMR studies provided further mechanistic insight. This knowledge guided an in silico screening of 62 different catalysts using an ONIOM(B3LYP/6-31G*:AM1) transition-state modeling, which showed good correlation between theory and experiment. The top-scored compound was easily synthesized from levoglucosenone, a biomass-derived chiral enone, and evaluated in the DA reaction between (E)-cinnamaldehyde and cyclopentadiene. In line with the computational finding, excellent results (up to 97% ee) were obtained. In addition, the catalyst could be easily recovered and reused with no loss in its catalytic activity. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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