1. Pharmacokinetics of dibekacin in children with cystic fibrosis.
- Author
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Courcol RJ, Loeuille GA, Delnatte J, and Martin GR
- Subjects
- Aspartate Aminotransferases blood, Child, Creatinine blood, Cystic Fibrosis drug therapy, Dibekacin blood, Dibekacin therapeutic use, Humans, Kinetics, Time Factors, Cystic Fibrosis metabolism, Dibekacin metabolism, Kanamycin analogs & derivatives
- Abstract
Dosages and pharmacokinetics of dibekacin were studied in a group of 15 children with cystic fibrosis (CF) and a control group of 9 children. The mean dosage regimens of dibekacin were respectively equal to 2.19 mg/kg and 2.16 mg/kg in the CF and non-CF patients. The mean peak serum values for the CF and non-CF groups were respectively equal to 5.3 micrograms/ml. Comparison of pharmacokinetic parameters (i.e. half-life, distribution volume, total body clearance and area under the curve) showed no significant difference between the two groups (p greater than 0.05).
- Published
- 1985