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Leptospirosis, a public health issue, is an infectious condition caused by bacteria of genus Leptospira. The disease comes under the category of acute febrile illness and manifests with fever (~Jvara), chills (~Jadyata), headache (~Shirahshula), myalgia (~Angamarda), vomiting (~Chardi), or diarrhea (~Atisara). The advanced form of the disease threatens life by causing either liver or kidney failure or meningitis or respiratory distress. Ayurveda classical literature provides an in-depth stage-wise description and treatment of Jvara (~febrile illness). This is an evidence-based case report of the rapid normalization of decreased platelet count by administering Amruthotharam kashayam and Punarnavadi kashayam in low frequent dose in a case of leptospirosis suspect.