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Introduction: Phyllodes tumours are rare neoplasms, representing less than 1% of all primary tumours of the breast. Case report: We report the case of a woman who presented with a malignant phyllodes tumour of the breast, with an osteosarcomatous component. A year after surgery, a control thoracic CT scan revealed nodules in the lung. Shortly after, she also developed cardiac and dermo-hypodermic lesions, histologically characterized as angiosarcoma with an osteoclastic component. Discussion: Malignant breast phyllodes tumour often metastasizes to the lungs, bones, liver and brain. To the best of our knowledge, there is only one case in literature that reports a cutaneous metastasis of phyllodes tumour under the form of an angiosarcoma, whilst, to date, no such myocardial involvement has been reported.