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Phase aberration is widely considered a major source of image degradation in medical pulse-echo ultrasound. Traditionally, near-field phase aberration correction techniques are unable to account for distributed aberrations due to a spatially varying speed of sound in the medium, while most distributed aberration correction techniques require the use of point-like sources and are impractical for clinical applications where diffuse scattering is dominant. Here, we present two distributed aberration correction techniques that utilize sound speed estimates from a tomographic sound speed estimator that builds on our previous work with diffuse scattering in layered media. We first characterize the performance of our sound speed estimator and distributed aberration correction techniques in simulations where the scattering in the media is known a priori. Phantom and in vivo experiments further demonstrate the capabilities of the sound speed estimator and the aberration correction techniques. In phantom experiments, point target resolution improves from 0.58 to 0.26 and 0.27 mm, and lesion contrast improves from 17.7 to 23.5 and 25.9 dB, as a result of distributed aberration correction using the eikonal and wavefield correlation techniques, respectively. [ABSTRACT FROM AUTHOR]

Phase aberration is one of the major sources of image degradation in medical ultrasound imaging. One of the earliest and simplest techniques to correct for phase aberration involves nearest-neighbor cross correlation to estimate delays between neighboring receive channels and the compensation of aberration delays in a delay-and-sum beamformer. The main challenge is that neighboring receive channels may not have sufficient signal correlation to accurately estimate the aberration delays. Although algorithms such as the translating transmit aperture or the common midpoint gather are designed to perfectly maximize signal correlations between received signals, these algorithms require the use of different transmit apertures for each received signal. Instead, this work proposes the use of a single globally-applicable transmit apodization function that optimizes the lag-one coherence based on the van Cittert–Zernike theorem. For the application to phase aberration correction, it is shown across 20 different zero-mean Gaussian-random aberrators that the proposed optimal apodization function reduces the estimation error in the aberration delay profile from 22.85% to 15.72%. • Significance: Aberration delays are often estimated using nearest-neighbor cross correlation. • Innovation: Transmit apodization that maximizes correlation between neighboring receive channels. • Results: Increased spatial coherence over short lags and improved aberration delay estimates. [ABSTRACT FROM AUTHOR]