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Copyright of Psychiatrie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Medicina Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Pediatrie pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Hypertrophic cardiomyopathy (HCM) is a heterogeneous disease with variable phenotypic expression. There has been a significant advancement in the diagnosis, treatment and influencing of the prognosis of patients in recent years. Aim: To describe the characteristics of the patients with sarcomeric hypertrophic cardiomyopathy hospitalized in a tertiary care centre and to evaluate diagnostic and therapeutic interventions in this group of patients. Patients and methods: We retrospectively analyzed data from the Hospital Information System from January 1, 2013 to April 27, 2023. The study included 213 patients who met the criteria for the definition of hypertrophic cardiomyopathy. There were 145 (68.1%) patients with the obstructive form (HOCM) and 68 (31.9%) patients without obstruction. Results: The median age was 55 years (IQR 43-64), with a gender distribution of 108/105 (male/ female). There were a total of 184 patients (86.4%) in the NYHA functional class II-IV. Cardiac magnetic resonance was performed in almost 30% of all patients. The percentage of patients who underwent genetic analysis was 15%. Betablockers were the most frequently indicated drug group (63.8% in total). Septal reduction therapies were performed in 8.5% of patients. Heart transplantation was performed in 15 patients (7%), dominantly in the non-obstructive group (17.6 vs 2.1%, p <.0001). We observed worse survival rate in the non-obstructive versus obstructive group (p=0.04). Conclusion: Based on this analysis, specialized care is required almost exclusively in symptomatic patients, despite the fact that most patients with HCM are asymptomatic and the disease is associated with a risk of sudden cardiac death. The availability/implementation of cardiac magnetic resonance, as well as genetic examination and counseling does not correspond to current recommendations. Patients with a non-obstructive form of HCM had a worse prognosis. Examinations focused on the presence of a specific myocardial hypertrophy etiology is not a standard diagnostic process. Availability of septal reduction therapy is good. [ABSTRACT FROM AUTHOR]

Copyright of Urologie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Urologie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Dermatologie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Neurologie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Celiac disease (CD) is a gastrointestinal disorder caused by the immune system’s response to gluten, involving both innate and adaptive immune reactions. It leads to various neurological issues, such as gluten ataxia, gluten neuropathy, epilepsy, and gluten encephalopathy. Although neurological presentations are rare in children, they are observed in up to 36% of adult patients with CD. Recent evidence suggests that these manifestations may be linked to gluten-related mechanisms, including antibody cross-reactions, immune-complex deposition, direct neurotoxicity, and, in severe cases, vitamin or nutrient deficiencies. However, there is still no consensus on whether serological, neurophysiological, or neuroimaging findings can effectively diagnose and monitor CD-associated neurological problems at an early stage. The identification of multimodal biomarkers and suitable neuroimaging tools could aid in the diagnosis, monitoring, and enhancement of the quality of life for individuals with neuroceliac disease. Nonetheless, it is essential to provide appropriate treatment to those with CD and neurological symptoms, as prolonged suffering may lead to irreversible disability. The primary treatment for neurological manifestations of gluten-related disorders is a strict gluten-free diet, although a small number of patients may require additional immunosuppressive therapy, typically using mycophenolate or intravenous immunoglobulins. In this literature review, our aim was to explore the relevant neurological disorders associated with CD, early diagnostic and treatment options to prevent related disability in affected patients. Clinicians should consider CD as a potential cause in individuals presenting with unexplained neurological dysfunction. [ABSTRACT FROM AUTHOR]

Cancer is a major risk factor for venous thromboembolism (VTE). The incidence of cancer-associated thrombosis (CAT) in cancer patients is increasing due to improved antitumor treatment options and the prolongation of patients’ lives. It constitutes up to 25% of all VTE cases. CAT causes higher morbidity and mortality, as well as a deterioration in the quality of life. Daily subcutaneous low-molecular-weight heparin (LMWH) has been the standard treatment for CAT for years. Data on the safety and efficacy of direct oral anticoagulants (DOACs) in this population have emerged in recent years and have been included in recent international guidelines. For the acute-phase treatment, the anti-Xa inhibitors (apixaban, edoxaban, rivaroxaban) showed better efficacy than LMWH in preventing VTE recurrence; however, rivaroxaban and edoxaban were also associated with an increased risk of bleeding events. Recent guidelines recommend DOACs for the treatment of CAT in selected cancer patients (eg, low bleeding risk, no luminal gastrointestinal or genitourinary malignancies, no interfering medications). [ABSTRACT FROM AUTHOR]

Copyright of Urologie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Neurologie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Pediatrie pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Urologie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Primary hyperaldosteronism (PH), i.e. Conn syndrome, is considered the most common cause of endocrine hypertension with the prevalence of 5-10% in the general population of hypertensive subjects and 20-30% in patients with resistant and severe hypertension. Therefore its systematic screening among hypertonics is very important. Screening of PH should be a part of differential diagnosis in selected groups of hypertonics, especially those with resistant or severe diastolic hypertension. Because long term aldosterone overproduction may cause severe organ complications such as cardiovascular and cerebrovascular events and renal impairment, it is necessary to recognize and to treat this syndrome very early. This review is focused on clinical management of patients with PH based on current guidelines. [ABSTRACT FROM AUTHOR]

Copyright of Urologie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Dermatologie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Remedia is the property of Medical Tribune CZ, s.r.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Folia Pharmaceutica Cassoviensia is the property of University of Veterinary Medicine & Pharmacy in Kosice and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Urologie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Urologie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Pediatrie pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

We are presenting the case of retroperitoneal tumor, which is a tumor with a high malignancy potential. Recommended therapy of these tumors is radical surgery, which is often difficult due to its anatomy and frequent advanced stage presentation. That is the reason why it has to be provided in specialized centers. According to the STRASS study there is no benefit of combined neoadjuvant radiotherapy with radical surgical approach compared to surgical therapy alone. [ABSTRACT FROM AUTHOR]

Copyright of Medicina Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Studia Pneumologica et Phthiseologica is the property of TRIOS, spol. sr.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Medicina Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Many neurodegenerative diseases are defi ned by the aggregation and accumulation of the specific pathological protein in the CNS, leading to irreversible and fatal changes of the tissues. However, due to high clinical and epidemiological heterogeneity, a definitive ante-mortem diagnosis is very difficult to perform. The definitive dia gnosis is confirmed by neuropathological evaluation made only at autopsy. Hope for early and accurate laboratory diagnostics of these diseases within a patient’s life represents methods based on the detection of seeding activity of pathological proteins. An example is a highly specific and ultrasensitive new method called Real-Time Quaking- Induced Conversion (RT-QuIC) assay. Originally, RT-QuIC was developed for the diagnosis of prions showing 92–97% sensitivity and 100% specificity. In our laboratory, we were able to detect prions in 39 brain samples, corresponding 24 cerebrospinal fluid samples, and in 38 skin samples of patients with Creutzfeldt-Jakob disease using RT-QuIC. Lately, the use of the RT-QuIC method for detection of pathological protein -synuclein, which accumulates during Parkinson’s disease or dementia with Lewy bodies, and tau protein which is characteristic for Alzheimer’s disease or corticobasal degeneration, was described. This review aims to elucidate the diagnosis of neurodegenerative diseases and its recent approaches using RT-QuIC. [ABSTRACT FROM AUTHOR]

The authors provide an overview of the current terminology and etiopathology of allergic inflammation and current options for the diagnosis and treatment of allergic diseases with a focus on practical activities in the outpatient clinics of general practitioners and specialists in other fields who come into contact with allergic patients. From pharmacotherapy are high‑ lighted antihistamines – the most frequently prescribed drugs in allergology and biological treatment – as the latest ap‑ proach to the treatment of allergic inflammation. [ABSTRACT FROM AUTHOR]

Copyright of Psychiatrie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Praktické Lékárenství is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The aim of this case report is to discuss a very rare pathology – temporal bone meningioma. The extracranial location of meningiomas and temporal bone meningioma is a very rare condition. The symptomatology of temporal bone meningiomas is nonspecific, imitating chronic otitis media with cholesteatoma. However, temporal bone meningioma has a distinctive image on computed tomography. There is a change in the architecture without bone destruction that should be known by otorhinolaryngologist and radiologist. Magnetic resonance paging should be performed when temporal bone meningioma is suspected. The management of temporal bone meningiomas depends on a variety of factors. The most common therapy includes a combination of neurosurgical and otological surgery. There are also alternatives like stereotactic irradiation. [ABSTRACT FROM AUTHOR]

Copyright of Medicina Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Neurologie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Primary ciliary dyskinesia (PCD) is a rare genetic diseases with diverse clinical symptoms. Clinicians should think of PCD in the differential diagnostic process in both children and adults who suffer from recurrent or chronic upper and lower respiratory tract symptoms frequently accompanied by hearing impairment. The first manifestations of PCD often occur very early in life and might present as an acute respiratory distress syndrome of a newborn or neonatal rhinitis. During the whole life the patients suffer from chronic wet cough and recurrent airway and lung inflammations, which can result in bronchiectasis. Situs viscerum inversus, other laterality defects and fertility disorders are other common symptoms in PCD. Early diagnosis and complex therapy play a key role in the prognosis of PCD patients, as deterioration of lung functions and lung tissue destruction may occur at an early age in some phenotypes. [ABSTRACT FROM AUTHOR]

Copyright of Zdravotnicke listy is the property of Alexander Dubcek University in Trencin, Faculty of Nursing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Medicina Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Neuroendocrine tumors are rare tumors with different oncological potential, prognosis, and varied symptomatology. They are most often detected in the gastrointes- tinal tract and in the lungs. Authors present 2 patients with neuroendocrine carcinoma of the larynx who were treated at the Department of Otorhinolaryngology, FD Roosevelt Faculty Hospital, Banska Bystrica, Slovakia. Management of patients with this rare disease is discussed. [ABSTRACT FROM AUTHOR]

This article reviews the clinical presentation, diagnostic evaluation, risk stratification, and treatment of acute pericarditis. [ABSTRACT FROM AUTHOR]

Infectious encephalitis in immunosuppressed patients is a common and urgent condition that requires rapid diagnosis and early treatment. The disease can lead to severe neurological deficit and eventually result in the death of the patient. Usually infectious encephalitis presents with fever, headache, focal neurological deficits, and altered state of consciousness. Immunosuppressed patients pose a great differential diagnostic challenge since clinical symptoms, laboratory findings, and imaging tests are often attenuated and may imitate stroke or other non-infectious diseases. Therefore, infectious meningoencephalitis should be suspected in all immunosuppressed patients with acute focal neurological symptoms, even in the absence of fever and meningeal signs. Accordingly, physician should thoroughly evaluate patient's history, perform detailed physical examination, and carefully interpret test results. Early diagnosis and initiation of appropriate treatment of bacterial meningoencephalitis correlates with better prognosis for the patient. This article describes an atypical clinical case of a bacterial meningoencephalitis with stroke-like symptoms in a patient with multiple myeloma. In addition, the article reviews clinical presentation, diagnostic and treatment recommendations of infectious encephalitis in immunosuppressed patients. [ABSTRACT FROM AUTHOR]