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Vaginal carcinoma is a rare gynecological malignancy that is usually treated by radiation therapy and/or surgery combined with chemotherapy. Here, we report a case of invasive vaginal carcinoma in a young woman who underwent fertility-sparing treatment involving neoadjuvant chemotherapy and conservative surgery. A 36-year-old non-parous woman had a solid tumor in the vagina. Positron emission tomography/computed tomography showed a tumor in the vagina with high FDG uptake ( SUV = 17.33) but no metastatic lesions. The patient was diagnosed with vaginal squamous cell carcinoma, FIGO stage I, T1N0M0. Because she wished to retain her fertility, neoadjuvant chemotherapy consisting of irinotecan hydrochloride and nedaplatin was initiated. After four courses of chemotherapy, partial vaginectomy was carried out and the pathological diagnosis of the residual lesion was VAIN 3. Following two further courses of the same chemotherapy, she obtained complete response, and has shown no evidence of disease for 14 months. [ABSTRACT FROM AUTHOR]

Steroid cell tumor, not otherwise specified, is a rare type of ovarian sex cord-stromal tumor with malignant potential. Some of these tumors produce testosterone. We describe a case of steroid cell tumor of the ovary associated with virilization. A 23-year-old nulliparous woman was found to have an ovarian tumor when she visited her primary doctor for virilization and oligomenorrhea. Magnetic resonance imaging revealed a solid left ovarian tumor 40 mm in size. Her laboratory data revealed elevated testosterone with normal levels of gonadotropins, estradiol, dehydroepiandrosterone sulfate and cortisol. She underwent left adnexectomy. On histopathologic and immunohistochemical analyses, the tumor was diagnosed as steroid cell tumor, not otherwise specified, without malignant behavior. After removal of the tumor, serum testosterone level decreased, and there have been no signs of recurrence. [ABSTRACT FROM AUTHOR]

Evaluation of: Najy AJ, Day KC, Day ML: ADAM15 supports prostate cancer metastasis by modulating tumor cell-endothelial cell interaction. Cancer Res.6B, 1092-1099 (2008). Products of a disintegrin and metalloproteinase (ADAM) gene family are multifunctional proteins and have activities of metalloproteinase, integrin-binding, cell adhesion and intracellular signaling. ADAMs play important roles in many biological processes, such as neurogenesis, myogenesis, fertilization and growth factor shedding. Several ADAM genes are also implicated in various types of cancers: however, the exact function of ADAMs in tumorigenesis and tumor progression has not been well understood. In this report, Najy and colleagues have shown that ADAM15 plays a critical role in tumor growth and metastasis in human prostate cancer. Their results indicate that ADAM15 promotes the binding to extracellular matrix proteins, expression of metastatic-associated cell surface proteins, cleavage of N-cadherin and activation of matrix metalloproteinase 9. These events were followed by stimulation of transendothelial migration and bone metastasis. Therefore, ADAM15 signaling may serve as a potential therapeutic target for prostate cancer. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 20-year-old Japanese woman who was presented with a 1-year history of recurrent episodes of eyelid swelling without major urticaria. The patient was diagnosed with thermal angiooedema caused by showering in hot water. She was treated with chlorpheniramine and olopatadine hydrochloride.