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Background: It is critical that interventions used to enhance the healing of chronic foot ulcers in diabetes are backed by high-quality evidence and cost-effectiveness. In previous years, the systematic review accompanying guidelines published by the International Working Group of the Diabetic Foot performed 4-yearly updates of previous searches, including trials of prospective, cross-sectional and case-control design., Aims: Due to a need to re-evaluate older studies against newer standards of reporting and assessment of risk of bias, we performed a whole new search from conception, but limiting studies to randomised control trials only., Materials and Methods: For this systematic review, we searched PubMed, Scopus and Web of Science databases for published studies on randomised control trials of interventions to enhance healing of diabetes-related foot ulcers. We only included trials comparing interventions to standard of care. Two independent reviewers selected articles for inclusion and assessed relevant outcomes as well as methodological quality., Results: The literature search identified 22,250 articles, of which 262 were selected for full text review across 10 categories of interventions. Overall, the certainty of evidence for a majority of wound healing interventions was low or very low, with moderate evidence existing for two interventions (sucrose-octasulfate and leucocyte, platelet and fibrin patch) and low quality evidence for a further four (hyperbaric oxygen, topical oxygen, placental derived products and negative pressure wound therapy). The majority of interventions had insufficient evidence., Conclusion: Overall, the evidence to support any other intervention to enhance wound healing is lacking and further high-quality randomised control trials are encouraged., (© 2024 The Authors. Diabetes/Metabolism Research and Reviews published by John Wiley & Sons Ltd.)

Aims: Principles of wound management, including debridement, wound bed preparation, and newer technologies involving alternation of wound physiology to facilitate healing, are of utmost importance when attempting to heal a chronic diabetes-related foot ulcer. However, the rising incidence and costs of diabetes-related foot ulcer management necessitate that interventions to enhance wound healing of chronic diabetes-related foot ulcers are supported by high-quality evidence of efficacy and cost effectiveness when used in conjunction with established aspects of gold-standard multidisciplinary care. This is the 2023 International Working Group on the Diabetic Foot (IWGDF) evidence-based guideline on wound healing interventions to promote healing of foot ulcers in persons with diabetes. It serves as an update of the 2019 IWGDF guideline., Materials and Methods: We followed the GRADE approach by devising clinical questions and important outcomes in the Patient-Intervention-Control-Outcome (PICO) format, undertaking a systematic review, developing summary of judgements tables, and writing recommendations and rationale for each question. Each recommendation is based on the evidence found in the systematic review and, using the GRADE summary of judgement items, including desirable and undesirable effects, certainty of evidence, patient values, resources required, cost effectiveness, equity, feasibility, and acceptability, we formulated recommendations that were agreed by the authors and reviewed by independent experts and stakeholders., Results: From the results of the systematic review and evidence-to-decision making process, we were able to make 29 separate recommendations. We made a number of conditional supportive recommendations for the use of interventions to improve healing of foot ulcers in people with diabetes. These include the use of sucrose octasulfate dressings, the use of negative pressure wound therapies for post-operative wounds, the use of placental-derived products, the use of the autologous leucocyte/platelet/fibrin patch, the use of topical oxygen therapy, and the use of hyperbaric oxygen. Although in all cases it was stressed that these should be used where best standard of care was not able to heal the wound alone and where resources were available for the interventions., Conclusions: These wound healing recommendations should support improved outcomes for people with diabetes and ulcers of the foot, and we hope that widescale implementation will follow. However, although the certainty of much of the evidence on which to base the recommendations is improving, it remains poor overall. We encourage not more, but better quality trials including those with a health economic analysis, into this area., (© 2023 The Authors. Diabetes/Metabolism Research and Reviews published by John Wiley & Sons Ltd.)

Background: Diabetic foot ulceration (DFU) can be defined as a full-thickness wound below the ankle and is a major complication of diabetes mellitus. Despite best practice, many wounds fail to heal, and when they do, the risk of recurrence of DFU remains high. Beliefs about personal control, or influence, on ulceration are associated with better engagement with self-care in DFU. Psychological interventions aim to reduce levels of psychological distress and empower people to engage in self-care, and there is some evidence to suggest that they can impact positively on the rate of wound healing., Objectives: To evaluate the effects of psychological interventions on healing and recurrence of DFU., Search Methods: In September 2019, we searched the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL), Ovid MEDLINE (including In-Process & Other Non-Indexed Citations), Ovid Embase, Ovid PsycINFO and EBSCO CINAHL Plus. We also searched clinical trials registries for ongoing and unpublished studies, and reviewed reference lists of relevant included studies as well as reviews, meta-analyses and health technology reports to identify additional studies. There were no restrictions with respect to language, date of publication or study setting., Selection Criteria: We included randomised controlled trials (RCTs) and quasi-RCTs that evaluated psychological interventions compared with standard care, education or another psychological intervention. Our primary outcomes were the proportion of wounds completely healed; time to complete wound healing; time to recurrence and number of recurrences., Data Collection and Analysis: Four review authors independently screened titles and abstracts of the studies identified by the search strategy for eligibility. Three authors independently screened all potentially relevant studies using the inclusion criteria and carried out data extraction, assessment of risk of bias and GRADE assessment of the certainty of the evidence., Main Results: We identified seven trials that met the inclusion criteria with a total of 290 participants: six RCTs and one quasi-RCT. The studies were conducted in Australia, the USA, the UK, Indonesia, Norway and South Africa. Three trials used a counselling-style intervention and one assessed an intervention designed to enhance an understanding of well-being. One RCT used a biofeedback relaxation training intervention and one used a psychosocial intervention based on cognitive behavioural therapy. A quasi-RCT assessed motivation and tailored the intervention accordingly. Due to the heterogeneity of the trials identified, pooling of data was judged inappropriate, and we therefore present a narrative synthesis. Comparisons were (1) psychological intervention compared with standard care and (2) psychological intervention compared with another psychological intervention. We are uncertain whether there is a difference between psychological intervention and standard care for people with diabetic foot ulceration in the proportion of wounds completely healed (two trials, data not pooled, first trial RR 6.25, 95% CI 0.35 to 112.5; 16 participants, second trial RR 0.59, 95% CI 0.26 to 1.39; 60 participants), in foot ulcer recurrence after one year (two trials, data not pooled, first trial RR 0.67, 95% CI 0.32 to 1.41; 41 participants, second trial RR 0.63, 95% CI 0.05 to 7.90; 13 participants) or in health-related quality of life (one trial, MD 5.52, 95% CI -5.80 to 16.84; 56 participants). This is based on very low-certainty evidence which we downgraded for very serious study limitations, risk of bias and imprecision. We are uncertain whether there is a difference in the proportion of wounds completely healed in people with diabetic foot ulceration depending on whether they receive a psychological intervention compared with another psychological intervention (one trial, RR 2.33, 95% CI 0.92 to 5.93; 16 participants). This is based on very low-certainty evidence from one study which we downgraded for very serious study limitations, risk of bias and imprecision. Time to complete wound healing was reported in two studies but not in a way that was suitable for inclusion in this review. One trial reported self-efficacy and two trials reported quality of life, but only one reported quality of life in a manner that enabled us to extract data for this review. No studies explored the other primary outcome (time to recurrence) or secondary outcomes (amputations (major or distal) or cost)., Authors' Conclusions: We are unable to determine whether psychological interventions are of any benefit to people with an active diabetic foot ulcer or a history of diabetic foot ulcers to achieve complete wound healing or prevent recurrence. This is because there are few trials of psychological interventions in this area. Of the trials we included, few measured all of our outcomes of interest and, where they did so, we judged the evidence, using GRADE criteria, to be of very low certainty., (Copyright © 2021 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.)

Diabetes mellitus is a global epidemic. Peripheral neuropathy and peripheral vascular disease are complications of diabetes mellitus and the primary causative factors for foot ulceration. Foot ulceration is the leading cause of hospitalization in people with diabetes mellitus. The burden of foot ulceration on health care systems and individual patients is immense. Despite conventional treatment, there persists a high incidence of amputation. A multidisciplinary approach is required to prevent ulcers. This review describes the etiology and risk factors for diabetic foot ulceration and a system for evaluating the diabetic foot. The assessment of neuropathy and the grading of foot ulcers are critically examined. This is important to allow for standardization in clinical trials. The management of diabetic foot syndrome is reviewed. The treatments to ensure vascular supply to the lower limb and control of infection as well as novel therapies, which are becoming available to treat nonhealing, "no-option" diabetic ulcers, are discussed.

Background Diabetic foot ulcers (DFU) are complex, multifactorial and often complicated by delayed, impaired and uncoordinated wound healing. DFU are associated with devastating outcomes including infection, amputation and premature death. Aim The aim of this narrative literature review is to obtain a broad perspective on the pathophysiological mechanisms that contribute to delayed and impaired healing in the diabetic foot. Methods We undertook a review of the literature to critique and synthesise the evidence for pathophysiological factors that contribute to delayed and impaired healing in the diabetic foot. Findings It is evident from the literature that molecular mechanisms that give rise to impaired inflammation will impact upon healing, whilst physical parameters such as tissue hypoxia, pressure foot-loading, wound PH, temperature and biofilm can all contribute to delayed healing in the diabetic foot. Conclusions An understanding of the pathophysiology of impaired healing and a focus on controlling these disturbances can facilitate successful healing. To enhance the management of foot disease in diabetic patients, primary care professionals must be made aware of the significance of early referral to a specialised unit. When DFU do not heal adequately after 4 weeks of standard treatment, the underlying pathology should be re-evaluated, and the need for advanced therapy should be considered. Implications for clinical practice It is important that clinicians involved in treating DFU have an understanding of the pathophysiological mechanisms that cause delayed and impaired healing in the diabetic foot. When a DFU fails to respond to standard care within a 4-week period, the pathophysiology of the wound should be re-evaluated and advanced therapies should be considered. [ABSTRACT FROM AUTHOR]

Background Optimising wellbeing for those living with DFU is a critical component of holistic patient management. Evidence demonstrates that outcomes improve when patients are actively involved in their care. Yet, wellbeing is often overlooked for patients with DFU and there is a lack of measurement tools regarding this concept. Aim The aim of this research process was to identify--through PPI collaboration and engagement with patients--the potential for development of a wellbeing tool specifically for people living with DFU. Methods A PPI panel consisting of six members was established. The COM-B model as a framework and trigger questions on wellbeing were used as a focus for tool generation. The guidance for Reporting Involvement of Patients and the Public 2 -- Short Form (GRIPP2-SF) was used to guide the process. Findings All content was analysed using thematic analysis to map emerging themes and subthemes and create recommendations. A total of five recommendations were developed: 1. Patient education, 2. Self-efficacy, 3. Health literacy and knowledge translation, 4. Social support and 5. Holistic approach. Conclusions Further research in this area should comprehensively address the holistic elements of wellbeing to optimise outcomes for those with DFU. The development of an outcome tool for wellbeing is required to support further research. [ABSTRACT FROM AUTHOR]

Effective management of wound exudate in diabetic foot ulcers (DFUs) is a key component of any wound management plan and crucial to facilitate the healing of DFUs. It is important, therefore, that clinicians involved in the management of DFUs understand the role and function of wound exudate and, importantly, can recognise when exudate can become detrimental to the healing process. This article provides an overview of wound exudate, its role and constituents, and outlines current best practice in managing wound exudate to best facilitate wound healing and wound closure in DFUs. [ABSTRACT FROM AUTHOR]

Aim: To investigate pain in patients with Diabetic foot ulcer (DFU) and its impact on their HRQOL. Method: This was a cross-sectional descriptive study, obtained sample of 30 participants from MPPC, Galway, Ireland. Pain was assessed using short-form McGill questionnaire (SF-MPQ), HRQOL was assessed Cardiff Wound Impact schedule (CWIS) questionnaire. Results / Discussion: DFU pain was reported by 70% (n=21) of participants. The majority of participants (n=16) experience "mild" to "distressing" pain, the remaining 23 % (n=5) experiencing "severe" pain. The most common sensory pain descriptors reported were "tender", "aching", and "throbbing", indicating nociceptive pain. Significant correlations between VAS and total SF-MPQ score were observed across all CWIS domains and the total CWIS score. Social life (rs=-0.710, p=<0.001) and Physical symptoms and daily living and (rs=-0.665, p=<0.001) demonstrating the strongest negative correlations. Patients with no DFU pain experience superior quality of life (Mr=22, P=0.09) compared to DFU pain where both neuropathic and nociceptive pain coexist (Mr=9, P=0.09). With statistically significant differences in the domains Social Life (Mr=22, Mr=90). The presence of DFU negatively impacts patients' health-related quality of life (HRQOL) due to many factors, one of which is pain. There is a general misconception that patients with DFU do not experience wound-related pain due to the high incidence of diabetic neuropathy among them, attributing the presence of any DFU pain to ischaemia, infection and/or Charcot arthropathy. A growing evidence base challenges previous presumptions surrounding DFU pain, reporting this as a significant factor effecting HRQOL among people with DFU. Conclusion: This study identifies classification of DFU pain as a viable contributor to the identification and implementation of effective DFU management strategies. [ABSTRACT FROM AUTHOR]

Aim: To investigate wellbeing in those who are at high risk of or living with an active diabetic foot ulcer (DFU) attending a community Podiatry clinic in the West of Ireland. Method: A total of 25 participants at risk or/ active DFUs were recruited. In addition to demographic information, Phase 1 (n = 25) assessed: Spirituality Self Rating Scale (SSRS), Hearth Hope Index (HHI), Hospital Anxiety and Depression Score (HADS), Rosenberg Self-Esteem Scale (RSES) and Powerlessness Assessment Tool (PAT). Phase 2 (n = 10) utilised a qualitative approach and explored the lived experience of those at high risk (n=4) and those living with active (n = 6) DFU through one-to-one follow-up interviews. Results / Discussion: Sixty-four percent (n=16) had current ulceration. Mean age was 69.64 (±11.47) and disease duration 21.28 years (±10.76). Male: Female gender distribution was 76% (n = 19)/ 24% (n = 6). The following mean scores were identified: SSRS 21.24 (±6.78), HHI 37.28 (±6.17), RSES 20.84 (±5.02), PAT 28.88 (±7.91), and HADS = 9 (±5.33). Individuals with current DFU presented with lower levels of self-esteem, stronger feelings of powerlessness, higher levels of depression and lower levels of anxiety when compared to those who were at risk, but not currently ulcerated. Conclusion: Participants living with current DFUs reported stronger feelings of powerlessness, lower self-esteem and higher depression scores than those who are high risk of DFUs. Those with current DFUs reported significantly lower anxiety levels compared to the high-risk group. Healthcare professionals should consider the impact that DFU may have on wellbeing and future work should investigate if addressing these factors can improve patient outcomes. [ABSTRACT FROM AUTHOR]

Infection in diabetic foot ulcers puts patients at risk of hospitalisation and amputation. Microorganisms populate chronic wounds on a continuum from non-pathological surface contamination to local infection and/or deep compartment infection. Early diagnosis of infection based on relevant clinical signs and symptoms is critical, and treatment reflects the degree of infection. Treatment of superficial infection can involve dressings impregnated with antimicrobial agents. Dressing choice recommendations in clinical practice guidelines, however, are primarily used to ensure optimal moisture balance is achieved and facilitate autolytic debridement. Current evidence, although weak, favours antimicrobial dressings. Future research should be more robust and adequately powered. [ABSTRACT FROM AUTHOR]

Diabetic foot disease and chronic kidney disease (CKD) are strong predictive risk factors for the development of diabetic foot ulceration (DFU). Individuals with CKD, particularly those with end-stage renal disease (ESRD), are known to be at high risk of developing foot complications, including DFU and lower-extremity amputation. The onset and progression of CKD can be monitored through the analysis of estimated glomerular filtration rate (eGFR). The emerging literature investigating declining kidney function in association with DFU primarily focuses on stage 4 and stage 5 ESRD (e-GFR <29). Previous studies have identified a temporal relationship between dialysis and foot ulceration. Further research is warranted to comprehensively analyse the relationship between DFD and diabetic nephropathy to truly understand the interrelationship between these common, microvascular complications of diabetes. [ABSTRACT FROM AUTHOR]