1. The ROSA-Like Prophage Colonizing Staphylococcus aureus Promotes Intracellular Survival, Biofilm Formation, and Virulence in a Chronic Wound Environment.
- Author
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Ahmad-Mansour N, Plumet L, Pouget C, Kissa K, Dunyach-Remy C, Sotto A, Lavigne JP, and Molle V
- Subjects
- Animals, Staphylococcus aureus, Virulence, Prophages genetics, Zebrafish, Biofilms, Rosa, Diabetic Foot microbiology, Staphylococcal Infections microbiology
- Abstract
Background: The transition from colonization to invasion is critical in diabetic foot ulcer (DFU). Staphylococcus aureus can colonize DFU, or invade the underlying tissues, causing serious infections. The ROSA-like prophage has previously been implicated in strain colonization characteristics of S aureus isolates in uninfected ulcers., Methods: In this study, we investigated this prophage in the S aureus-colonizing strain using an in vitro chronic wound medium mimicking the chronic wound environment., Results: Chronic wound medium reduced bacterial growth and increased biofilm formation and virulence in a zebrafish model., Conclusions: The ROSA-like prophage promoted intracellular survival of S aureus-colonizing strain in macrophages, keratinocytes, and osteoblasts., Competing Interests: Potential conflicts of interest. All authors: No reported conflicts of interest., (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2023
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