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3 results on '"Agoas, V"'

1. Relevance of Retinal Thickness Changes in the OCT Inner and Outer Rings to Predict Progression to Clinical Macular Edema: An Attempt of Composite Grading of Macular Edema

Author

Giuseppe Querques, Torcato Santos, Caroline Coriat, Catarina Neves, Jose P. Martinez, Francesco Bandello, Frank D. Verbraak, Sobha Sivaprasad, José Cunha-Vaz, Henrik Lund-Andersen, Stela Vujosevic, Luisa Ribeiro, Dalila Alves, Frank G. Holz, Ali Erginay, Erica Smets, Catherine A Egan, Peter Wiedemann, Ignasi Jürgens, Sandrina Nunes, Monica Varano, Geeta Menon, Amparo Navea Tejerina, Victor Ágoas, Evicr Net, Vujosevic, S, Varano, M, Egan, C, Sivaprasad, S, Menon, G, Erginay, A, Verbraak, Fd, Lund Andersen, H, Martinez, Jp, Jurgens, I, Smets, E, Coriat, C, Wiedemann, P, Agoas, V, Querques, Giuseppe, Holz, Fg, Nunes, S, Alves, D, Neves, C, Santos, T, Ribeiro, L, Bandello, Francesco, Tejerina, An, Cunha Vaz, J., Biomedical Engineering and Physics, and Ophthalmology

Subjects
Male, Visual acuity, genetic structures, Visual Acuity, chemistry.chemical_compound, Diabetic retinopathy, 80 and over, Prospective Studies, skin and connective tissue diseases, Tomography, Aged, 80 and over, Diabetes, Macular edema, Optical coherence tomography, Adult, Aged, Diabetes Mellitus, Type 2, Diabetic Retinopathy, Disease Progression, Female, Follow-Up Studies, Humans, Macular Edema, Middle Aged, Organ Size, Retina, Sensitivity and Specificity, Tomography, Optical Coherence, Ophthalmology, Sensory Systems, Cellular and Molecular Neuroscience, medicine.diagnostic_test, General Medicine, medicine.anatomical_structure, medicine.symptom, Type 2, medicine.medical_specialty, Diabetes Mellitus, medicine, Grading (tumors), business.industry, Disease progression, Retinal, medicine.disease, eye diseases, chemistry, Optical Coherence, Human medicine, sense organs, business
Abstract

Purpose: To characterize the relevance of macular thickness changes in the inner and outer rings in the progression of macular edema in eyes/patients with diabetes type 2. Methods: A total of 374 type 2 diabetic patients with mild nonproliferative diabetic retinopathy (ETDRS levels 20-35) were included in a 12-month prospective observational study to identify retinopathy progression. Retinal thickness analyses were performed in 194 eyes/patients using Cirrus SD-OCT and 166 eyes/patients using Spectralis SD-OCT. The DRCR.net classification of subclinical and clinical macular edema was used. A composite grading of macular edema is proposed in this study. Results: A total of 317 eyes/patients completed the study. SD-OCT identified clinical macular edema in 24 eyes/patients (6.7%) and subclinical macular edema in 104 eyes/patients (28.9%) at baseline. Increased thickness of the central subfield is the best predictor for the development of clinical macular edema, with 85.7% sensitivity and 71.9% specificity (OR: 2.57, 95% CI: 0.82-7.99). However, the involvement of the inner and outer rings is a cumulative predictor of progression to clinical macular edema (OR: 8.69, 95% CI: 2.85-26.52). Conclusions: A composite OCT grading of macular edema taking into account the retinal thickness changes in the inner and outer macular rings offers a simple way to characterize macular edema, with added clinical value. (C) 2015 S. Karger AG, Basel OI Vujosevic, Stela/0000-0001-6773-9967 Purpose: To characterize the relevance of macular thickness changes in the inner and outer rings in the progression of macular edema in eyes/patients with diabetes type 2. Methods: A total of 374 type 2 diabetic patients with mild nonproliferative diabetic retinopathy (ETDRS levels 20-35) were included in a 12-month prospective observational study to identify retinopathy progression. Retinal thickness analyses were performed in 194 eyes/patients using Cirrus SD-OCT and 166 eyes/patients using Spectralis SD-OCT. The DRCR.net classification of subclinical and clinical macular edema was used. A composite grading of macular edema is proposed in this study. Results: A total of 317 eyes/patients completed the study. SD-OCT identified clinical macular edema in 24 eyes/patients (6.7%) and subclinical macular edema in 104 eyes/patients (28.9%) at baseline. Increased thickness of the central subfield is the best predictor for the development of clinical macular edema, with 85.7% sensitivity and 71.9% specificity (OR: 2.57, 95% CI: 0.82-7.99). However, the involvement of the inner and outer rings is a cumulative predictor of progression to clinical macular edema (OR: 8.69, 95% CI: 2.85-26.52). Conclusions: A composite OCT grading of macular edema taking into account the retinal thickness changes in the inner and outer macular rings offers a simple way to characterize macular edema, with added clinical value. (C) 2015 S. Karger AG, Basel

Published
2015
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2. Characterization of Retinal Disease Progression in a 1-Year Longitudinal Study of Eyes With Mild Nonproliferative Retinopathy in Diabetes Type 2

Author

Luisa Ribeiro, Francesco Bandello, Amparo Navea Tejerina, Stela Vujosevic, Monica Varano, Catherine Egan, Sobha Sivaprasad, Geeta Menon, Pascale Massin, Frank D. Verbraak, Henrik Lund-Andersen, Jose P. Martinez, Ignasi Jürgens, Erica Smets, Caroline Coriat, Peter Wiedemann, Victor Ágoas, Giuseppe Querques, Frank G. Holz, Sandrina Nunes, Catarina Neves, José Cunha-Vaz, null for the EVICR.net Study Group, EVICR Net Study Grp, Other Research, Biomedical Engineering and Physics, Ophthalmology, Amsterdam Cardiovascular Sciences, Amsterdam Neuroscience, Other departments, Ribeiro, L, Bandello, Francesco, Tejerina, An, Vujosevic, S, Varano, M, Egan, C, Sivaprasad, S, Menon, G, Massin, P, Verbraak, Fd, Lund Andersen, H, Martinez, Jp, Jurgens, I, Smets, E, Coriat, C, Wiedemann, P, Agoas, V, Querques, Giuseppe, Holz, Fg, Nunes, S, Neves, C, and Cunha Vaz, J.

Subjects
Male, Biomarkers, Diabetes type 2, Diabetic retinopathy, Macular edema, Microaneurysms, Diabetes Mellitus, Type 2, Diabetic Retinopathy, Disease Progression, Female, Follow-Up Studies, Humans, Middle Aged, Prognosis, Prospective Studies, Retina, Time Factors, Tomography, Optical Coherence, Visual Acuity, Ophthalmology, Sensory Systems, Cellular and Molecular Neuroscience, Medicine (all), medicine.medical_specialty, Visual acuity, genetic structures, chemistry.chemical_compound, Diabetes mellitus, Diabetes Mellitus, medicine, Prospective cohort study, Tomography, Subclinical infection, business.industry, Retinal, medicine.disease, eye diseases, chemistry, Optical Coherence, Human medicine, sense organs, medicine.symptom, business, Type 2, Retinopathy
Abstract

PURPOSE. To identify eyes of patients with diabetes type 2 that show progression of retinal disease within a 1-year period using noninvasive techniques. METHODS. Three hundred seventy-four type 2 diabetic patients with mild nonproliferative diabetic retinopathy (Early Treatment Diabetic Retinopathy Study [ETDRS] level 20 or 35) were included in a 12-month prospective observational study to identify retinopathy progression. Four visits were scheduled at 0, 3, 6, and 12 months. Microaneurysm (MA) activity using the RetmarkerDR and retinal thickness using spectral-domain optical coherence tomography (SD-OCT) were assessed by a central reading center at all visits and ETDRS severity level in the first and last visits. RESULTS. Three hundred thirty-one eyes/patients completed the study. Microaneurysm formation rate greater than or equal to 2 was present in 68.1% of the eyes and MA turnover greater than or equal to 6 in 54.0% at month 6. Higher MA turnover values were registered in eyes that showed progression in ETDRS severity level (P < 0.03). There were also significant correlations between increased microaneurysm activity and increases in retinal thickness. Spectral-domain OCT identified clinical macular edema in 24 eyes/patients (6.7%) and subclinical macular edema in 104 eyes/patients (28.9%) at baseline. Progression of retinal thickening was registered in eyes that had either subclinical or clinical macular edema at baseline. CONCLUSIONS. Changes in MA activity measured with RetmarkerDR and in central retinal thickness in eyes with mild nonproliferative diabetic retinopathy and diabetes type 2 are able to identify eyes at risk of progression. These eyes/patients should be selected for inclusion in future clinical trials of drugs targeted to prevent diabetic retinopathy progression to visionthreatening complications. PURPOSE. To identify eyes of patients with diabetes type 2 that show progression of retinal disease within a 1-year period using noninvasive techniques. METHODS. Three hundred seventy-four type 2 diabetic patients with mild nonproliferative diabetic retinopathy (Early Treatment Diabetic Retinopathy Study [ETDRS] level 20 or 35) were included in a 12-month prospective observational study to identify retinopathy progression. Four visits were scheduled at 0, 3, 6, and 12 months. Microaneurysm (MA) activity using the RetmarkerDR and retinal thickness using spectral-domain optical coherence tomography (SD-OCT) were assessed by a central reading center at all visits and ETDRS severity level in the first and last visits. RESULTS. Three hundred thirty-one eyes/patients completed the study. Microaneurysm formation rate greater than or equal to 2 was present in 68.1% of the eyes and MA turnover greater than or equal to 6 in 54.0% at month 6. Higher MA turnover values were registered in eyes that showed progression in ETDRS severity level (P < 0.03). There were also significant correlations between increased microaneurysm activity and increases in retinal thickness. Spectral-domain OCT identified clinical macular edema in 24 eyes/patients (6.7%) and subclinical macular edema in 104 eyes/patients (28.9%) at baseline. Progression of retinal thickening was registered in eyes that had either subclinical or clinical macular edema at baseline. CONCLUSIONS. Changes in MA activity measured with RetmarkerDR and in central retinal thickness in eyes with mild nonproliferative diabetic retinopathy and diabetes type 2 are able to identify eyes at risk of progression. These eyes/patients should be selected for inclusion in future clinical trials of drugs targeted to prevent diabetic retinopathy progression to visionthreatening complications.

Published
2015
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3. Retinal layer location of increased retinal thickness in eyes with subclinical and clinical macular edema in diabetes type 2

Author

Frank G. Holz, Caroline Coriat, Giuseppe Querques, Geeta Menon, Stela Vujosevic, Sandrina Nunes, Henrik Lund-Andersen, Torcato Santos, Monica Varano, Pascale Massin, Luisa Ribeiro, Amparo Navea Tejerina, Victor Ágoas, Frank D. Verbraak, Ignasi Jürgens, Catherine A Egan, Francesco Bandello, Peter Wiedemann, Catarina Neves, Sobha Sivaprasad, José Cunha-Vaz, Dalila Alves, Jose P. Martinez, R.M. Erica Smets, Bandello, Francesco, Tejerina, An, Vujosevic, S, Varano, M, Egan, C, Sivaprasad, S, Menon, G, Massin, P, Verbraak, Fd, Lund Andersen, H, Martinez, Jp, Jurgens, I, Smets, Rme, Coriat, C, Wiedemann, P, Agoas, V, Querques, Giuseppe, Holz, Fg, Nunes, S, Alves, D, Neves, C, Santos, T, Ribeiro, L, Cunha Vaz, J., EVICR net, Other Research, Biomedical Engineering and Physics, and Ophthalmology

Subjects
Adult, Male, medicine.medical_specialty, genetic structures, Macular Edema, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Young Adult, Diabetes mellitus, Ophthalmology, 80 and over, Diabetes Mellitus, Diabetes, Diabetic retinopathy, Macular edema, Optical coherence tomography, Aged, Aged, 80 and over, Algorithms, Diabetes Mellitus, Type 2, Diabetic Retinopathy, Female, Humans, Middle Aged, Organ Size, Prospective Studies, Retinal Neurons, Tomography, Optical Coherence, Sensory Systems, Medicine, Prospective cohort study, Tomography, Subclinical infection, business.industry, Retinal, General Medicine, medicine.disease, eye diseases, Surgery, chemistry, Optical Coherence, Human medicine, sense organs, business, Type 2
Abstract

Purpose:To identify the retinal layer predominantly affected in eyes with subclinical and clinical macular edema in diabetes type 2. Methods: A cohort of 194 type 2 diabetic eyes/patients with mild nonproliferative diabetic retinopathy (ETDRS levels 20/35) were examined with Cirrus spectral-domain optical coherence tomography (OCT) at the baseline visit (ClinicalTrials.gov identifier: NCT01145599). Automated segmentation of the retinal layers of the eyes with subclinical and clinical macular edema was compared with a sample of 31 eyes from diabetic patients with normal OCT and an age-matched control group of 58 healthy eyes. Results: From the 194 eyes in the study, 62 had subclinical macular edema and 12 had clinical macular edema. The highest increases in retinal thickness (RT) were found in the inner nuclear layer (INL; 33.6% in subclinical macular edema and 81.8% in clinical macular edema). Increases were also found in the neighboring layers. Thinning of the retina was registered in the retinal nerve fiber, ganglion cells and inner plexiform layers in the diabetic eyes without macular edema. Conclusions: The increase in RT occurring in diabetic eyes with macular edema is predominantly located in the INL but extends to neighboring retinal layers indicating that it may be due to extracellular fluid accumulation. (C) 2015 S. Karger AG, Basel Purpose:To identify the retinal layer predominantly affected in eyes with subclinical and clinical macular edema in diabetes type 2. Methods: A cohort of 194 type 2 diabetic eyes/patients with mild nonproliferative diabetic retinopathy (ETDRS levels 20/35) were examined with Cirrus spectral-domain optical coherence tomography (OCT) at the baseline visit (ClinicalTrials.gov identifier: NCT01145599). Automated segmentation of the retinal layers of the eyes with subclinical and clinical macular edema was compared with a sample of 31 eyes from diabetic patients with normal OCT and an age-matched control group of 58 healthy eyes. Results: From the 194 eyes in the study, 62 had subclinical macular edema and 12 had clinical macular edema. The highest increases in retinal thickness (RT) were found in the inner nuclear layer (INL; 33.6% in subclinical macular edema and 81.8% in clinical macular edema). Increases were also found in the neighboring layers. Thinning of the retina was registered in the retinal nerve fiber, ganglion cells and inner plexiform layers in the diabetic eyes without macular edema. Conclusions: The increase in RT occurring in diabetic eyes with macular edema is predominantly located in the INL but extends to neighboring retinal layers indicating that it may be due to extracellular fluid accumulation. (C) 2015 S. Karger AG, Basel

Published
2015

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