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Your search keyword '"Martijn C.G.J. Brouwers"' showing total 3 results
Start Over Author "Martijn C.G.J. Brouwers" Topic diabetes mellitus, type 2
3 results on '"Martijn C.G.J. Brouwers"'

1. Intrahepatic lipid content is independently associated with soluble E-selectin levels: The Maastricht study

Author

Martijn C.G.J. Brouwers, Nynke Simons, Marianne Eline Kooi, Rianneke de Ritter, Martien C.J.M. van Dongen, Simone J.P.M. Eussen, Otto Bekers, Jeroen Kooman, Marleen M.J. van Greevenbroek, Carla J.H. van der Kallen, Miranda T. Schram, Nicolaas C. Schaper, Casper G. Schalkwijk, Coen D.A. Stehouwer, Interne Geneeskunde, MUMC+: MA Endocrinologie (9), RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, RS: Carim - B06 Imaging, Beeldvorming, MUMC+: DA BV Klinisch Fysicus (9), Epidemiologie, RS: CAPHRI School for Public Health and Primary Care, MUMC+: DA CDL (5), MUMC+: DA CDL Analytisch cluster 1K (9), MUMC+: DA CDL Toegelatenen (9), RS: Carim - B01 Blood proteins & engineering, Central Diagnostic Lab, MUMC+: MA Nefrologie (9), RS: NUTRIM - R3 - Respiratory & Age-related Health, MUMC+: HVC Pieken Maastricht Studie (9), RS: Carim - V02 Hypertension and target organ damage, MUMC+: MA Interne Geneeskunde (3), MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Maag Darm Lever (9), MUMC+: MA Hematologie (9), MUMC+: MA Medische Oncologie (9), and MUMC+: MA Reumatologie (9)

Subjects
RISK, Hepatology, NASH, Gastroenterology, Endothelial Cells, Vascular Cell Adhesion Molecule-1, FATTY LIVER, Intercellular Adhesion Molecule-1, Lipids, Cohort Studies, Cross-Sectional Studies, Diabetes Mellitus, Type 2, ENDOTHELIAL DYSFUNCTION, Humans, Sinusoidal endothelial cell, E-Selectin, Non-alcoholic fatty liver disease
Abstract

BACKGROUND: Evidence is accumulating that liver sinusoidal endothelial cells are involved in the pathogenesis of non-alcoholic fatty liver disease. Previous studies have suggested that the endothelial biomarker soluble E-selectin (sE-selectin) is to an important extent liver-derived.AIMS: To study the relationship of intrahepatic lipid (IHL) content with sE-selectin at the population level.METHODS: This study was conducted in participants of The Maastricht Study (n = 1,634), a population-based cohort study enriched with patients with type 2 diabetes. We assessed the cross-sectional association between IHL content, quantified by MRI, and sE-selectin via multivariable regression with adjustment for age, sex, type 2 diabetes, educational level, BMI, Dutch Healthy Diet index, physical activity, and the Matsuda index.RESULTS: Standardized IHL content was associated with (log) sE-selectin (age-, sex- and type 2 diabetes-adjusted regression coefficient [B]: 0.048 [95%CI:0.038;0.058], pCONCLUSION: IHL content is an independent determinant of sE-selectin at the population level. These findings support further studies to unravel the involvement of liver sinusoidal endothelial cells in the different stages of non-alcoholic fatty liver disease and the specific role of E-selectin herein.

Published
2022

2. Fructose Intake From Fruit Juice and Sugar-Sweetened Beverages Is Associated With Higher Intrahepatic Lipid Content

Author

Amée M. Buziau, Simone J.P.M. Eussen, M. Eline Kooi, Carla J.H. van der Kallen, Martien C.J.M. van Dongen, Nicolaas C. Schaper, Ronald M.A. Henry, Miranda T. Schram, Pieter C. Dagnelie, Marleen M.J. van Greevenbroek, Anke Wesselius, Otto Bekers, Steven J.R. Meex, Casper G. Schalkwijk, Coen D.A. Stehouwer, Martijn C.G.J. Brouwers, Interne Geneeskunde, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, Beeldvorming, MUMC+: DA BV Klinisch Fysicus (9), RS: Carim - B06 Imaging, RS: CAPHRI - R2 - Creating Value-Based Health Care, RS: Carim - V02 Hypertension and target organ damage, MUMC+: HVC Pieken Maastricht Studie (9), RS: NUTRIM - R3 - Respiratory & Age-related Health, Complexe Genetica, MUMC+: DA CDL (5), MUMC+: DA CDL Analytisch cluster 1K (9), MUMC+: DA CDL Toegelatenen (9), RS: Carim - B01 Blood proteins & engineering, Central Diagnostic Lab, Biochemie, MUMC+: DA CDL Algemeen (9), MUMC+: MA Interne Geneeskunde (3), MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), and MUMC+: MA Endocrinologie (9)

Subjects
Male, Sugar-Sweetened Beverages, Advanced and Specialized Nursing, Endocrinology, Diabetes and Metabolism, Fructose, Middle Aged, Lipids, Beverages, Cohort Studies, Fruit and Vegetable Juices, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Metabolic Diseases, Fruit, Internal Medicine, Humans, Female, Aged
Abstract

OBJECTIVE Epidemiological evidence regarding the relationship between fructose intake and intrahepatic lipid (IHL) content is inconclusive. We, therefore, assessed the relationship between different sources of fructose and IHL at the population level. RESEARCH DESIGN AND METHODS We used cross-sectional data from The Maastricht Study, a population-based cohort study (n = 3,981; mean ± SD age: 60 ± 9 years; 50% women). We assessed the relationship between fructose intake (assessed with a food-frequency questionnaire)—total and derived from fruit, fruit juice, and sugar-sweetened beverages (SSB)—and IHL (quantified with 3T Dixon MRI) with adjustment for age, sex, type 2 diabetes, education, smoking status, physical activity, and intakes of total energy, alcohol, saturated fat, protein, vitamin E, and dietary fiber. RESULTS Energy-adjusted total fructose intake and energy-adjusted fructose from fruit were not associated with IHL in the fully adjusted models (P = 0.647 and P = 0.767). In contrast, energy-adjusted intake of fructose from fruit juice and SSB was associated with higher IHL in the fully adjusted models (P = 0.019 and P = 0.009). Individuals in the highest tertile of energy-adjusted intake of fructose from fruit juice and SSB had a 1.04-fold (95% CI 0.99; 1.11) and 1.09-fold (95% CI 1.03; 1.16) higher IHL, respectively, in comparison with the lowest tertile in the fully adjusted models. Finally, the association for fructose from fruit juice was stronger in individuals with type 2 diabetes (P for interaction = 0.071). CONCLUSIONS Fructose from fruit juice and SSB is independently associated with higher IHL. These cross-sectional findings contribute to current knowledge in support of measures to reduce the intake of fructose-containing beverages as a means to prevent nonalcoholic fatty liver disease at the population level.

Published
2022

3. Use of sodium-glucose co-transporter 2 inhibitors, changes in body mass index and risk of fracture: A population-based cohort study

Author

Judith van Dalem, Nikki C.C. Werkman, Joop P. van den Bergh, Bernardette Rossi, Rikke Viggers, Richard Eastell, Andrea M. Burden, Coen D.A. Stehouwer, Olaf H. Klungel, Martijn C.G.J. Brouwers, Johanna H.M. Driessen, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, MUMC+: DA KFT Medische Staf (9), Clinical Pharmacy, RS: NUTRIM - R3 - Respiratory & Age-related Health, Interne Geneeskunde, RS: CAPHRI - R5 - Optimising Patient Care, MUMC+: MA Interne Geneeskunde (3), and MUMC+: MA Endocrinologie (9)

Subjects
Adult, Symporters, Endocrinology, Diabetes and Metabolism, Sodium, General Medicine, Body Mass Index, Type 2 diabetes mellitus, Sodium-glucose co-transporter-2 inhibitors, BMI, Fracture, Cohort study, Cohort Studies, Glucose, Sulfonylurea Compounds, Endocrinology, Diabetes Mellitus, Type 2, Internal Medicine, Humans, Hypoglycemic Agents, Sodium-Glucose Transporter 2 Inhibitors, Osteoporotic Fractures, Retrospective Studies
Abstract

Aims: Sodium-glucose co-transporter-2 (SGLT-2) inhibitor-induced weight loss might play a role in the debated elevated fracture risk with these agents. The aim of the current study was to investigate the association between SGLT-2 inhibitor use, changes in body mass index (BMI) and fracture risk. Methods: A retrospective cohort study was conducted using data from the UK Clinical Practice Research Datalink (CPRD) GOLD (2013–2018). The study population (N = 34,960) consisted of adults with diabetes initiating a sulphonylurea or SGLT-2 inhibitor. Cox proportional hazards models estimated hazard ratios (HRs) for major osteoporotic fracture with SGLT-2 inhibitor use versus sulphonylurea use, stratified by change in BMI, average daily dose and cumulative dose. Analyses were adjusted for age, sex, lifestyle variables, comorbidities, and concomitant drug use. Results: SGLT-2 inhibitor use was not associated with an increased fracture risk compared to sulphonylurea use (adjusted HR 1.19; 95% confidence interval (CI): 0.80–1.79). This finding remained consistent after stratification by BMI change. However, the highest cumulative dose category was associated with an increased fracture risk (adjusted HR: 2.10, 95 %CI: 1.11–3.99). Conclusion: SGLT-2 inhibitor use was not associated with increased osteoporotic fracture risk, irrespective of change in BMI. However, a high cumulative dose could be an important risk factor., Diabetes Research and Clinical Practice, 190

Published
2022

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