27 results on '"Colwell JA"'
Search Results
2. Does aspirin use reduce cardiovascular risk in diabetes?
- Author
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Colwell JA
- Subjects
- Aspirin administration & dosage, Atherosclerosis epidemiology, Atherosclerosis etiology, Cardiovascular Diseases epidemiology, Cardiovascular Diseases etiology, Humans, Platelet Aggregation Inhibitors administration & dosage, Aspirin therapeutic use, Atherosclerosis complications, Atherosclerosis prevention & control, Cardiovascular Diseases prevention & control, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 drug therapy, Platelet Aggregation Inhibitors therapeutic use
- Abstract
The use of aspirin for the primary prevention of cardiovascular events in patients with type 2 diabetes mellitus is controversial. According to the findings of a Japanese trial, aspirin does not reduce the risk of cardiovascular events in this group of patients, unless they are aged 65 years and above.
- Published
- 2009
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- View/download PDF
3. Dental endosseous implant assessments in a type 2 diabetic population: a prospective study.
- Author
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Olson JW, Shernoff AF, Tarlow JL, Colwell JA, Scheetz JP, and Bingham SF
- Subjects
- Adult, Age Factors, Aged, Blood Glucose analysis, Dental Implants, Dental Prosthesis Design, Dental Prosthesis, Implant-Supported, Dental Restoration Failure, Denture, Overlay, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 prevention & control, Follow-Up Studies, Glycated Hemoglobin analysis, Humans, Jaw, Edentulous rehabilitation, Jaw, Edentulous surgery, Male, Mandible surgery, Middle Aged, Osseointegration, Prospective Studies, Regression Analysis, Smoking physiopathology, Time Factors, Treatment Outcome, Wound Healing, Dental Implantation, Endosseous, Diabetes Mellitus, Type 2 physiopathology
- Abstract
Diabetes mellitus, a prevalent disorder worldwide, is associated with systemic adverse sequelae, such as wound healing alterations, which may affect osseointegration of dental implants. This prospective multicenter study assessed the success of 2-stage endosseous root-form implants (3 different implant systems) placed in the mandibular symphysis of 89 male type 2 diabetic subjects. The implants were uncovered approximately 4 months after placement, restored with an implant-supported, Hader bar clip-retained overdenture, and maintained at scheduled follow-up data collection examinations for 60 months after loading. Sixteen (9.0%) of the 178 implants failed. Life table methods calculated implant survival at approximately 88%, from prosthesis placement through the 60-month follow-up, and at approximately 90% from implant placement through the observation period. No implants failed between surgical placement and uncovering, 5 failed at uncovering, 7 failed after uncovering before prosthesis placement, and 4 failed after prosthesis placement. Fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c) values were determined before implant placement (baseline) and approximately 4 months later at surgical uncovering (follow-up). The 5-year implant outcomes (successes versus failures) were analyzed against the following predictor variables: (1) baseline and follow-up FPG values, (2) baseline and follow-up HbA1c values, (3) subject age, (4) duration of diabetes (years), (5) baseline diabetic therapy, (6) smoking history, and (7) implant length. Regression analysis found only duration of diabetes (P < .025) and implant length (P < .001) to be statistically significant predictors of implant failure. There was no statistically significant difference in failure rates between the 3 different implant systems used. This study supports the use of dental implants in type 2 diabetic patients.
- Published
- 2000
4. Effect of intensive glycemic control on microalbuminuria in type 2 diabetes. Veterans Affairs Cooperative Study on Glycemic Control and Complications in Type 2 Diabetes Feasibility Trial Investigators.
- Author
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Levin SR, Coburn JW, Abraira C, Henderson WG, Colwell JA, Emanuele NV, Nuttall FQ, Sawin CT, Comstock JP, and Silbert CK
- Subjects
- Adult, Aged, Blood Glucose Self-Monitoring, Creatinine urine, Diabetes Mellitus, Type 2 blood, Drug Administration Schedule, Exercise, Follow-Up Studies, Glycated Hemoglobin analysis, Humans, Hypoglycemic Agents therapeutic use, Male, Middle Aged, Smoking Cessation, Time Factors, Albuminuria, Blood Glucose metabolism, Diabetes Mellitus, Type 2 therapy, Diabetes Mellitus, Type 2 urine, Insulin therapeutic use
- Abstract
Objective: Microalbuminuria can reflect the progress of microvascular complications and may be predictive of macrovascular disease in type 2 diabetes. The effect of intensive glycemic control on microalbuminuria in patients in the U.S. who have had type 2 diabetes for several years has not previously been evaluated., Research Design and Methods: We randomly assigned 153 male patients to either intensive treatment (INT) (goal HbA(1c) 7.1%) or to standard treatment (ST) (goal HbA(1c) 9.1%; P = 0.001), and data were obtained during a 2-year period. Mean duration of known diabetes was 8 years, mean age of the patients was 60 years, and patients were well matched at baseline. We obtained 3-h urine samples for each patient at baseline and annually and defined microalbuminuria as an albumin:creatinine ratio of 0.03-0.30. All patients were treated with insulin and received instructions regarding diet and exercise. Hypertension and dyslipidemia were treated with similar goals in each group., Results: A total of 38% of patients had microalbuminuria at entry and were evenly assigned to both treatment groups. INT retarded the progression of microalbuminuria during the 2-year period: the changes in albumin:creatinine ratio from baseline to 2 years of INT versus ST were 0.045 vs. 0.141, respectively (P = 0.046). Retardation of progressive urinary albumin excretion was most pronounced in those patients who entered the study with microalbuminuria and were randomized to INT. Patients entering with microalbuminuria had a deterioration in creatinine clearance at 2 years regardless of the intensity of glycemic control. In the group entering without microalbuminuria, the subgroup receiving ST had a lower percentage of patients with a macrovascular event (17%) than the subgroup receiving INT (36%) (P = 0.03). Use of ACE inhibitors or calcium-channel blockers was similarly distributed among the groups., Conclusions: Intensive glycemic control retards microalbuminuria in patients who have had type 2 diabetes for several years but may not lessen the progressive deterioration of glomerular function. Increases in macrovascular event rates in the subgroup entering without albuminuria who received INT remain unexplained but could reflect early worsening, as observed with microvascular disease in the Diabetes Control and Complications Trial.
- Published
- 2000
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5. Two years of intensive glycemic control and left ventricular function in the Veterans Affairs Cooperative Study in Type 2 Diabetes Mellitus (VA CSDM).
- Author
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Pitale SU, Abraira C, Emanuele NV, McCarren M, Henderson WG, Pacold I, Bushnell D, Colwell JA, Nuttall FQ, Levin SR, Sawin CT, Comstock JP, and Silbert CK
- Subjects
- Blood Pressure, Diabetes Mellitus, Type 2 blood, Drug Therapy, Combination, Follow-Up Studies, Glycated Hemoglobin analysis, Humans, Insulin therapeutic use, Male, Middle Aged, Radionuclide Ventriculography, Sulfonylurea Compounds therapeutic use, Time Factors, Blood Glucose metabolism, Diabetes Mellitus, Type 2 drug therapy, Diabetes Mellitus, Type 2 physiopathology, Hypoglycemic Agents therapeutic use, Ventricular Function, Left
- Abstract
Objective: The Veterans Affairs Cooperative Study in Type 2 Diabetes Mellitus (VA CSDM) was a multicenter randomized prospective study of 153 male type 2 diabetic patients to assess the ability to sustain clinically significant glycemic separation between intensive and standard treatment arms. A trend toward an excess of combined cardiovascular events in the intensive treatment arm of this trial was reported earlier. The present analysis was done to evaluate the effect of 2 years of intensive glycemic control on the left ventricular (LV) function., Research Design and Methods: The patients were randomized to intensive step treatment with insulin alone or with sulfonylurea (intensive treatment arm [INT], n = 75) or to standard once-daily insulin injection (standard treatment arm [STD], n = 78) treatment. A total of 136 patients (standard treatment arm [STD], n = 70; INT, n = 66) had radionuclide ventriculography at entry and at 24 months for the assessment of LV function., Results: There was no difference in the mean LV ejection fraction (at entry: STD 57.1+/-9.51%; INT 58.1+/-8.7%; at 24 months: STD 57.3+/-10.8%, INT 59.5+/-10.7%), peak filling rate (at entry: STD 2.6+/-0.7 end diastolic volume per second, INT 2.4+/-0.8 end diastolic volume per second; at 24 months: STD 2.7+/-1.0 end diastolic volume per second, INT 2.5+/-0.7 end diastolic volume per second), or time to peak filling rate (at entry: STD 195.3+/-69.5 ms, INT 185.6 +/-62.4 ms; at 24 months: STD 182.6+/-64.8 ms, INT 179.2+/-61.2 ms) between the 2 treatment arms. A subgroup analysis of 104 patients (STD, n = 53; INT, n = 51) that omitted individuals with intervening cardiac events/revascularization or a change in cardioactive medications also showed no difference in the LV function at entry and at 24 months between the 2 groups. Abnormal LV ejection fraction at baseline predicted cardiac events (interval between cardiac beats [RR] = 2.5)., Conclusions: Two years of intensive glycemic control does not affect the LV systolic or diastolic function in patients with type 2 diabetes.
- Published
- 2000
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6. Response to intensive therapy steps and to glipizide dose in combination with insulin in type 2 diabetes. VA feasibility study on glycemic control and complications (VA CSDM).
- Author
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Abraira C, Henderson WG, Colwell JA, Nuttall FQ, Comstock JP, Emanuele NV, Levin SR, Sawin CT, and Silbert CK
- Subjects
- Adult, Aged, Blood Glucose metabolism, Blood Glucose Self-Monitoring, Diabetes Mellitus, Type 2 blood, Drug Administration Schedule, Drug Therapy, Combination, Fasting, Glipizide administration & dosage, Glipizide adverse effects, Humans, Hypoglycemic Agents administration & dosage, Hypoglycemic Agents adverse effects, Insulin administration & dosage, Insulin adverse effects, Male, Middle Aged, Prospective Studies, Diabetes Mellitus, Type 2 drug therapy, Glipizide therapeutic use, Glycated Hemoglobin analysis, Hypoglycemic Agents therapeutic use, Insulin therapeutic use
- Abstract
Objective: The feasibility study for the VA Cooperative Study on Glycemic Control and Complications in Type 2 Diabetes (VA CSDM) prospectively studied 153 insulin-requiring type 2 diabetes patients, randomized between an intensively treated arm and a standard treatment arm during a mean follow-up of 27 months. The glycemic response to each of the progressive, sequential phases of insulin treatment was assessed, along with the incidence of hypoglycemic reactions and the relative efficacy of different doses of glipizide in combination with fixed doses of insulin., Research Design and Methods: Five medical centers participated; half of the patients were assigned to the intensive treatment arm aiming for normal HbA1c levels. Age of patients was 60 +/- 6 years, duration of diabetes 8 +/- 3 years, and BMI 30.7 +/- 4 kg/m2. A four-step management technique was used, with patients moving to the next step if the operational goals were not met: Phase I, evening intermediate or long-acting insulin; phase II, added day-time glipizide; phase III, two injections of insulin alone; and phase IV, multiple daily insulin injections. Home glucose monitoring measurements were done twice daily and at 3:00 A.M. once a week. Hypoglycemic reactions and home glucose monitoring results were recorded and counted in each of the treatment phases., Results: Baseline HbA1c was 9.3 +/- 1.8%, and fasting plus serum glucose was 11.4 +/- 3.3 mmol/1. Fasting serum glucose fell to near normal in phase I, and remained so in the other treatment phases. An HbA1c separation of 2.1% between the arms was maintained during the course of the study, while the intensive arm kept HbA1c levels below 7.3% (P = 0.001). Most of the decrease in HbA1c occurred with one injection of insulin alone (phase I, -1.4%) or adding day-time glipizide (phase II, -1.9% compared with baseline). HbA1c did not decrease further after substituting two injections of insulin alone, with twice the insulin dose. Multiple daily injections resulted in an additional HbA1c fall (-2.4% compared with baseline). However, two-thirds of the patients were still on one or two injections a day at the end of the study. Changes in home glucose monitoring levels paralleled those of the HbA1c, as did the increments in number of reported hypoglycemic reactions, virtually all either "mild" or "moderate" in character. For the combination of glipizide and insulin (phase II), the only significant effect was obtained with daily doses up to 10 mg a day; there were no significant additional benefits with up to fourfold higher daily doses, and HbA1c levels had an upward trend with doses > 20 mg/day., Conclusions: A simple regime of a single injection of insulin, alone or with glipizide, seemed sufficient to obtain clinically acceptable levels of HbA1c for most obese, insulin-requiring type 2 diabetes patients. Further decrease of HbA1c demanded multiple daily injections at the expense of doubling the insulin dose and the rate of hypoglycemic events. In combination therapy, doses of glipizide > 20 mg/day offered no additional benefit.
- Published
- 1998
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7. Ethnic differences in the glycemic response to exogenous insulin treatment in the Veterans Affairs Cooperative Study in Type 2 Diabetes Mellitus (VA CSDM).
- Author
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Agrawal L, Emanuele NV, Abraira C, Henderson WG, Levin SR, Sawin CT, Silbert CK, Nuttall FQ, Comstock JP, and Colwell JA
- Subjects
- Adult, Aged, Black People, Body Mass Index, C-Peptide blood, Diabetes Mellitus, Type 2 blood, Hospitals, Veterans, Humans, Male, Middle Aged, Sulfonylurea Compounds therapeutic use, United States, White People, Black or African American, Blood Glucose metabolism, Diabetes Mellitus, Type 2 drug therapy, Ethnicity, Glycated Hemoglobin analysis, Hypoglycemic Agents therapeutic use, Insulin therapeutic use
- Abstract
Objective: The Veterans Affairs Cooperative Study in Type 2 Diabetes Mellitus was conducted in NIDDM patients to determine if a significant difference in HbA1c could be achieved between groups receiving standard and intensive treatment. We observed differences in the response to exogenous insulin between African-Americans and other intensively treated patients. Therefore, we assessed the variations of response and correlated factors that might explain such differences., Research Design and Methods: One hundred fifty-three men aged 40-69 years with NIDDM for < or = 15 years were randomized to either the standard therapy (n = 78) or the intensive therapy (n = 75) arm. Of the 75 patients in the intensive therapy group, 57 completed the study on insulin therapy alone. Of these, 18 were African-Americans and 39 were non-African-Americans. We conducted an analysis of the data collected to determine differences in baseline characteristics, glycemic response, insulin requirement, body weight, exercise, and basal C-peptide level, factors that may explain a difference in response to insulin therapy., Results: Glycemic control improved in all patients with intensive insulin therapy. African-Americans achieved a greater improvement in HbA1c compared with non-African-Americans with a similar increment in insulin. This difference could not be explained by differences in body weight, activity, concomitant use of other medicines, or insulin-secretory capacity of the pancreas., Conclusions: We conclude that ethnic differences may exist in the response to insulin therapy. A knowledge of such differences may aid in achieving good glycemic control, especially since minorities have a greater prevalence of and burden from the microvascular complications of diabetes.
- Published
- 1998
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8. A critical issue. Intensive insulin treatment and macrovascular disease.
- Author
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Abraira C, Colwell JA, Nuttall F, Emanuele N, Comstock J, Levin S, Sawin C, and Silbert C
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- Cardiovascular Diseases epidemiology, Clinical Trials as Topic, Diabetes Mellitus drug therapy, Diabetes Mellitus physiopathology, Diabetes Mellitus, Type 2 physiopathology, Diabetic Angiopathies prevention & control, Feasibility Studies, Humans, Obesity, Cardiovascular Diseases prevention & control, Diabetes Mellitus, Type 2 drug therapy, Insulin therapeutic use
- Published
- 1998
- Full Text
- View/download PDF
9. Multifactorial aspects of the treatment of the type II diabetic patient.
- Author
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Colwell JA
- Subjects
- Arteriosclerosis epidemiology, Arteriosclerosis etiology, Arteriosclerosis prevention & control, Aspirin therapeutic use, Cardiovascular Diseases etiology, Cardiovascular Physiological Phenomena, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 physiopathology, Diabetic Angiopathies etiology, Humans, Hyperglycemia complications, Hyperglycemia drug therapy, Hypoglycemic Agents therapeutic use, Platelet Aggregation Inhibitors therapeutic use, Risk Factors, Thrombosis epidemiology, Thrombosis etiology, Thrombosis prevention & control, Cardiovascular Diseases epidemiology, Cardiovascular Diseases prevention & control, Diabetes Mellitus, Type 2 drug therapy, Diabetic Angiopathies epidemiology, Diabetic Angiopathies prevention & control
- Abstract
People with type II diabetes have a twofold to fourfold increased risk of dying from the complications of cardiovascular disease. Atherosclerosis and vascular thrombosis are major contributors. The increased risk is present before fasting hyperglycemia is seen. These individuals often have a sedentary life-style, poor physical conditioning, insulin resistance, centripetal obesity, hypertension, dyslipidemia, and a prothrombotic state. Chronic hyperglycemia is then added to these risk markers. Microalbuminuria may precede hyperglycemia in type II diabetes, occurs in 30% to 40% of these individuals after diabetes is established, and is a predictor of cardiovascular events. Early intervention in high-risk individuals may delay or prevent fasting hyperglycemia. An all-inclusive approach that focuses on early risk factor (or marker) identification and management to prevent or delay accelerated atherosclerosis and thrombosis in type II diabetes is an attractive strategy. However, the database to support this strategy is limited. In particular, large-scale prospective trial data are not available to support the concept of intensive glycemic regulation to prevent progression of macrovascular disease in type II diabetes. This is in contrast to the situation regarding microvascular disease of the eyes and kidneys. Recently, indirect data of a correlative nature have emerged, and short- and long-term prospective trials at early and late stages of type II diabetes are now being reported. These studies are analyzed and interpreted in this report. In contrast, the database to support an intensive antiplatelet regimen to prevent vascular thrombotic events in people with type II diabetes is large, and these studies are reviewed. They are of a type and magnitude to allow definite recommendations for aspirin therapy in type II diabetes. Aggressive therapy directed at hypertension, hyperlipidemia, and elevated urinary albumin in people with type II diabetes appears to be indicated. Increased attention to the multifactorial aspects of treatment of the type II diabetic patient is needed. Our present challenge is to translate these findings for patients and primary health care providers so that effective actions may be implemented.
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- 1997
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10. Controlling type 2 diabetes: are the benefits worth the costs?
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Colwell JA
- Subjects
- Blood Glucose, Cost of Illness, Cost-Benefit Analysis, Diabetes Mellitus, Type 2 economics, Diabetes Mellitus, Type 2 physiopathology, Disease Management, Humans, Insulin adverse effects, Practice Guidelines as Topic, Diabetes Mellitus, Type 2 drug therapy, Glycated Hemoglobin metabolism, Insulin therapeutic use, Outcome Assessment, Health Care
- Published
- 1997
11. Pharmacological strategies to prevent macrovascular disease in NIDDM.
- Author
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Colwell JA
- Subjects
- Humans, Hyperglycemia complications, Arteriosclerosis prevention & control, Diabetes Mellitus, Type 2 drug therapy, Diabetic Angiopathies prevention & control, Thrombosis prevention & control
- Abstract
The pathogenesis of atherosclerosis and vascular thrombosis in NIDDM is reviewed. Evidence that suggests a role for chronic hyperglycemia, in association with other vascular risk markers, is presented. Based on this framework, a multifactorial approach to the prevention of progression of macrovascular disease in NIDDM is discussed. Results from a recent consensus conference sponsored by the American Diabetes Association regarding approaches to glycemic regulation in people with NIDDM are reviewed. It is concluded that preventive approaches will materially alter the course of macrovascular disease, reduce health care costs, and improve the quality of life for people with NIDDM.
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- 1997
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12. Aspirin therapy in diabetes mellitus.
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Colwell JA
- Subjects
- Aspirin adverse effects, Diabetes Mellitus, Type 1 physiopathology, Diabetes Mellitus, Type 2 physiopathology, Diabetic Angiopathies epidemiology, Gastrointestinal Hemorrhage chemically induced, Gastrointestinal Hemorrhage prevention & control, Humans, Placebos, Platelet Aggregation Inhibitors adverse effects, Risk Factors, Tablets, Enteric-Coated, Aspirin therapeutic use, Diabetes Mellitus, Type 1 drug therapy, Diabetes Mellitus, Type 2 drug therapy, Diabetic Angiopathies prevention & control, Platelet Aggregation Inhibitors therapeutic use
- Published
- 1997
13. Should we use intensive insulin therapy after oral agent failure in type II diabetes?
- Author
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Colwell JA
- Subjects
- Administration, Oral, Albuminuria, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Diabetes Mellitus, Type 2 physiopathology, Diabetic Angiopathies epidemiology, Diabetic Angiopathies mortality, Diabetic Neuropathies prevention & control, Diabetic Retinopathy prevention & control, Glycated Hemoglobin analysis, Humans, Hypoglycemic Agents administration & dosage, Morbidity, Risk Factors, Treatment Failure, Diabetes Mellitus, Type 2 drug therapy, Diabetic Angiopathies prevention & control, Hypoglycemic Agents therapeutic use, Insulin therapeutic use
- Published
- 1996
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14. Intensive insulin therapy in type II diabetes: rationale and collaborative clinical trial results.
- Author
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Colwell JA
- Subjects
- Arteriosclerosis prevention & control, Aspirin therapeutic use, Blood Glucose metabolism, Diabetic Angiopathies prevention & control, Dose-Response Relationship, Drug, Humans, Hyperglycemia complications, Male, Thrombosis prevention & control, Diabetes Mellitus, Type 2 drug therapy, Insulin administration & dosage
- Abstract
The rationale for intensive insulin therapy and results from major clinical trials in diabetes are reviewed. The Diabetes Control and Complications Trial (DCCT) has shown that intensive insulin therapy will prevent or delay the onset of retinopathy, nephropathy, and neuropathy in type I diabetes. The University Group Diabetes Program (UGDP) and the U.K. Prospective Diabetes Study (UKPDS) have addressed the issue of insulin versus oral agent or diet therapy in people with recently diagnosed type II diabetes. The UGDP showed that effective glycemic control could be achieved with intensive insulin therapy, but no effect on vascular end points was seen. Early data from the UKPDS also suggest that intensive insulin therapy may be more effective in lowering HbA1c toward normal than oral agents or diet. A pressing clinical problem is the question of the use of intensive insulin therapy in type II diabetic individuals who remain hyperglycemic despite pharmacological therapy. A Veterans Affairs Cooperative Study explored the feasibility of using intensive insulin therapy in 153 male type II diabetic patients with these characteristics. A 2% lowering of HbA1c was seen, with no increase in weight gain or in hypoglycemia. However, 40 of 153 patients (26.1%) had cardiovascular events during the 27-month trial; no difference in cardiovascular event rates was seen between the two treatment groups. A long-term multicenter collaborative trial is needed to assess the benefit:risk ratio of intensive insulin therapy for type II diabetic patients in whom pharmacological therapy failed to provide glycemic management.
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- 1996
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15. The feasibility of intensive insulin management in non-insulin-dependent diabetes mellitus. Implications of the Veterans Affairs Cooperative Study on Glycemic Control and Complications in NIDDM.
- Author
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Colwell JA
- Subjects
- Adult, Diabetes Mellitus, Type 2 blood, Drug Administration Schedule, Feasibility Studies, Glipizide therapeutic use, Glycated Hemoglobin metabolism, Hospitals, Veterans, Humans, Hypoglycemic Agents administration & dosage, Insulin administration & dosage, Male, Middle Aged, Treatment Outcome, Diabetes Mellitus, Type 2 drug therapy, Hypoglycemic Agents therapeutic use, Insulin therapeutic use
- Abstract
Objective: To review the results from the Veterans Affairs Cooperative Study on Glycemic Control and Complications in NIDDM (VACSDM) and to discuss the implications of the results from this feasibility trial., Design: A randomized clinical trial comprising 153 men with non-insulin-dependent diabetes mellitus (NIDDM) who remained hyperglycemic on usual pharmacologic therapy. Patients were randomized into two groups receiving either standard or intensive insulin therapy and were followed for 27 months., Setting: Five Veterans Affairs medical centers., Patients: 153 men with NIDDM, aged 40 to 69 years, who had hemoglobin A1c (HbA1c) levels of greater than 6.55% while receiving sulfonylurea or insulin therapy., Intervention: Standard insulin therapy was one or two insulin injections daily. Intensive insulin therapy was done using a stepwise approach: 1) evening intermediate or long-acting insulin; 2) addition of daytime glipizide; 3) insulin twice daily, with no glipizide; and 4) insulin three to four times daily, with no glipizide., Measurements: Fasting blood glucose and HbA1c levels, retinopathy, lipid and urinary albumin levels, cardiovascular events, hypoglycemia, and body mass index., Results: In the intensive group, the HbA1c level fell 2.07 percentage points; the mean HbA1c level was 7.3% from 6 months onward. The standard group experienced little change. These changes occurred without significant weight gain and with a very low rate of severe hypoglycemia. Sixteen patients (20.5%) in the standard group and 24 patients (32%) in the intensive group had cardiovascular events (P = 0.1)., Conclusions: It is feasible to achieve excellent glycemic control in men with NIDDM in whom standard pharmacologic therapy has failed. The benefit/risk ratio of intensive insulin management in this patient group is not established and has been made the subject of a long-term prospective clinical trial.
- Published
- 1996
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16. Forum Two: Unanswered research questions about metabolic control in non-insulin-dependent diabetes mellitus.
- Author
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Colwell JA and Clark CM Jr
- Subjects
- Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 complications, Female, Humans, Hyperglycemia blood, Hyperglycemia etiology, Male, Blood Glucose metabolism, Diabetes Mellitus, Type 2 therapy, Hyperglycemia prevention & control
- Abstract
The participants of Forum Two addressed the unanswered research questions about metabolic control and non-insulin-dependent diabetes mellitus (NIDDM). The most compelling issue was the effect of metabolic control on both the development and progression of macrovascular disease in patients with NIDDM. Associated questions that could be answered by a well-controlled clinical trial related to the goal of blood glucose control in NIDDM in the elderly and in persons with clinical vascular disease. The specific suggestion was a trial similar to the Veterans Affairs Cooperative Study on Glycemic Control and Complications in NIDDM. Another important research issue that was discussed was the benefit of treating other risk factors such as hypertension and hyperlipidemia in diabetic patients. Yet another area discussed was the study of health services delivery to examine the best care-delivery methods for diabetes and other chronic diseases. Other areas of discussion centered on basic research, that is, the fundamental cause of insulin resistance and the genetics of NIDDM and the loss of protection against atherosclerosis in postmenopausal women with diabetes.
- Published
- 1996
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17. Release of platelet plasminogen activator inhibitor 1 in whole blood is increased in patients with type II diabetes.
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Jokl R, Klein RL, Lopes-Virella MF, and Colwell JA
- Subjects
- Adult, Aged, Analysis of Variance, C-Peptide blood, Cholesterol blood, Cholesterol, HDL blood, Cholesterol, LDL blood, Cholesterol, VLDL blood, Cohort Studies, Diabetic Angiopathies blood, Female, Glycated Hemoglobin analysis, Humans, Hypertension blood, In Vitro Techniques, Insulin blood, Male, Middle Aged, Platelet Activation, Platelet Aggregation, Reference Values, Triglycerides blood, Blood Platelets physiology, Diabetes Mellitus, Type 2 blood, Plasminogen Activator Inhibitor 1 blood
- Abstract
Objective: To compare platelet plasminogen activator inhibitor 1 (PAI-1) release in type II diabetic patients and healthy control subjects., Research Design and Methods: We studied a group of 27 diabetic patients and a group of 16 nondiabetic control subjects. Whole-blood platelet aggregation, defined as a decrease in platelet count during shaking (180 rpm) of blood samples at 37 degrees C, and plasma PAI-1 antigen concentrations were measured in parallel at time 0, 7.5, 15, 30, 60, 120, and 180 min., Results: Platelet aggregation did not differ significantly between the two groups at any time period. However, the increase in plasma PAI-1 antigen concentration over basal levels at time 0 was higher for the group of diabetic patients when compared with their matched control subjects. The increment of PAI-1 antigen was 61.8 +/- 29.4 vs. 35.9 +/- 13.4 ng/ml (P < 0.005, means +/- SD) after 180 min for the diabetic and control subjects, respectively. Platelet PAI-1 release was correlated to very-low-density lipoprotein cholesterol and triglyceride plasma levels, but not to HbA1c levels., Conclusions: Platelets of patients with type II diabetes release significantly more PAI-1 than platelets of healthy subjects at the same level of platelet aggregation. This may contribute to enhanced thrombosis in diabetes.
- Published
- 1995
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18. Veterans Affairs Cooperative Study on glycemic control and complications in type II diabetes (VA CSDM). Results of the feasibility trial. Veterans Affairs Cooperative Study in Type II Diabetes.
- Author
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Abraira C, Colwell JA, Nuttall FQ, Sawin CT, Nagel NJ, Comstock JP, Emanuele NV, Levin SR, Henderson W, and Lee HS
- Subjects
- Aged, Albuminuria epidemiology, Animals, Biomarkers blood, Blood Glucose Self-Monitoring, Blood Pressure, Body Mass Index, Cholesterol blood, Cholesterol, HDL blood, Cholesterol, LDL blood, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 drug therapy, Feasibility Studies, Glycated Hemoglobin analysis, Hospitals, Animal, Humans, Male, Middle Aged, Patient Selection, Quality Control, Smoking, Time Factors, Triglycerides blood, United States, Blood Glucose metabolism, Diabetes Mellitus, Type 2 physiopathology, Diabetic Angiopathies epidemiology, Diabetic Retinopathy epidemiology, Glipizide therapeutic use, Hypoglycemic Agents therapeutic use, Insulin therapeutic use
- Abstract
Objective: It is not clear whether intensive pharmacological therapy can be effectively sustained in non-insulin-dependent diabetes mellitus (NIDDM). The relative risks and benefits of intensive insulin therapy in NIDDM are not well defined. Accordingly, we designed a feasibility study that compared standard therapy and intensive therapy in a group of NIDDM men who required insulin due to sustained hyperglycemia., Research Design and Methods: A prospective trial was conducted in five medical centers in 153 men of 60 +/- 6 years of age who had a known diagnosis of diabetes for 7.8 +/- 4 years. They were randomly assigned to a standard insulin treatment group (one morning injection per day) or to an intensive therapy group designed to attain near-normal glycemia and a clinically significant separation of glycohemoglobin from the standard arm. A four-step plan was used in the intensive therapy group along with daily self-monitoring of glucose: 1) an evening insulin injection, 2) the same injection adding daytime glipizide, 3) two injections of insulin alone, and 4) multiple daily injections. Patient accrual and adherence, glycohemoglobin (HbA1c), side effects, and measurements of endpoints for a prospective long-term trial were assessed., Results: Accrual goals were met, mean follow-up time was 27 months (range 18-35 months), and patients kept 98.6% of scheduled visits. After 6 months, the mean HbA1c in the intensive therapy group was at or below 7.3% and remained 2% lower than the standard group for the duration of the trial. Most of the decrease in the mean HbA1c in the intensive group was obtained by a single injection of evening intermediate insulin, alone or with daytime glipizide. By the end of the trial, 64% of the patients had advanced to two or more injections of insulin a day, aiming for normal HbA1c. However, only a small additional fall in HbA1c was attained. Severe hypoglycemia was rare (two events per 100 patients per year) and not significantly different between the groups, nor were changes in weight, blood pressure, or plasma lipids. There were 61 new cardiovascular events in 40 patients and 10 deaths (6 due to cardiovascular causes)., Conclusions: Intense stepped insulin therapy in NIDDM patients who have failed glycemic control on pharmacological therapy is effective in maintaining near-normal glycemic control for > 2 years without excessive severe hypoglycemia, weight gain, hypertension, or dyslipidemia. Cardiovascular event rates are high at this stage of NIDDM. A long-term prospective trial is needed to assess the risk-benefit ratio of intensified treatment of hyperglycemia in NIDDM patients requiring insulin.
- Published
- 1995
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19. Implants for type II diabetic patients: interim report. VA Implants in Diabetes Study Group.
- Author
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Shernoff AF, Colwell JA, and Bingham SF
- Subjects
- Dental Prosthesis Design, Evaluation Studies as Topic, Follow-Up Studies, Humans, Male, Prospective Studies, Prosthesis Failure, Dental Care for Chronically Ill methods, Dental Implantation, Endosseous, Dental Implants, Diabetes Mellitus, Type 2
- Abstract
One hundred seventy-eight implants from three systems were placed in 89 type II diabetic patients at 13 Department of Veterans Affairs medical centers. Four failures (2.2 percent) were found at uncovering. The failure rate increased to 7.3 percent at the end of 1 year (nine additional failures). Study patients will be monitored for an additional 4 years. Initial results suggest that type II diabetic patients can be considered for dental implant therapy.
- Published
- 1994
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20. Platelet plasminogen activator inhibitor 1 in patients with type II diabetes.
- Author
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Jokl R, Laimins M, Klein RL, Lyons TJ, Lopes-Virella MF, and Colwell JA
- Subjects
- Blood Pressure, C-Peptide blood, Cholesterol blood, Diabetes Mellitus, Type 2 physiopathology, Diabetes Mellitus, Type 2 therapy, Diet, Diabetic, Female, Glycated Hemoglobin analysis, Humans, Hypoglycemic Agents therapeutic use, In Vitro Techniques, Male, Middle Aged, Platelet Aggregation, Platelet Factor 4 analysis, Reference Values, Triglycerides blood, beta-Thromboglobulin analysis, Blood Platelets metabolism, Diabetes Mellitus, Type 2 blood, Plasminogen Activator Inhibitor 1 blood
- Abstract
Objective: To compare platelet plasminogen activator inhibitor 1 (PAI-1) concentration in type II diabetic patients and healthy control subjects., Research Design and Methods: We studied a group of 12 diabetic patients whose disease was controlled by diet or sulfonylurea therapy and a group of 17 nondiabetic control subjects. All subjects were free of clinically advanced vascular disease. PAI-1 antigen concentrations were measured in 5 x 10(8) isolated platelets, which were lysed by 1% Triton X-100., Results: Mean platelet PAI-1 was significantly higher in diabetic patients (264 +/- 83 ng/5 x 10(8) platelets) compared with control subjects (202 +/- 71 ng/5 x 10(8) platelets) (P < 0.05). A significant independent positive correlation was found between platelet PAI-1 concentrations and fasting plasma specific insulin levels in the diabetic patients (r = 0.63, P = 0.03)., Conclusions: These findings suggest that 1) a higher platelet PAI-1 concentration may contribute to enhanced thrombosis in type II diabetes and 2) megakaryocyte PAI-1 synthesis may be under the control of insulin.
- Published
- 1994
- Full Text
- View/download PDF
21. Is it time to introduce metformin in the U.S.?
- Author
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Colwell JA
- Subjects
- Blood Glucose metabolism, Clinical Trials as Topic, Diabetes Mellitus, Type 2 blood, Humans, United States, Diabetes Mellitus, Type 2 drug therapy, Metformin therapeutic use
- Published
- 1993
- Full Text
- View/download PDF
22. Effects of gemfibrozil on triglyceride levels in patients with NIDDM. Hyperlipidemia in Diabetes Investigators.
- Author
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Vinik AI and Colwell JA
- Subjects
- C-Peptide blood, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 drug therapy, Double-Blind Method, Female, Glycated Hemoglobin analysis, Humans, Hyperlipidemias complications, Hyperlipidemias drug therapy, Hypoglycemic Agents therapeutic use, Insulin therapeutic use, Male, Middle Aged, Diabetes Mellitus, Type 2 blood, Gemfibrozil therapeutic use, Hyperlipidemias prevention & control, Triglycerides blood
- Abstract
Objective: Patients with NIDDM have a two- to fourfold increased risk of macrovascular disease. The constellation of elevated TGs and decreased HDL cholesterol are recognized as risk factors and constitute the major dyslipidemia in NIDDM. We therefore sought to determine if gemfibrozil (600 mg b.i.d.) was effective in correcting the dyslipidemia of NIDDM., Research Design and Methods: After 8 wk of placebo stabilization, 442 patients from 46 study centers were randomized to double-blind treatment, in a designated 2:1 ratio, 295 received gemfibrozil and 147 received placebo for 20 wk. The primary end point was plasma TG; secondary end points were TC, LDL cholesterol, VLDL cholesterol, HDL cholesterol, and HbA1c. No baseline differences were noted between groups in sex, age, weight, type of diabetic therapy, fasting plasma levels of TGs, HbA1c, or C-peptide. About two-thirds received oral hypoglycemic drugs, one-third insulin., Results: TG fell 26.4% in the gemfibrozil group and rose 7.4% in the placebo group (P < 0.023), by an intent-to-treat analysis. When patients who were noncompliant or with inadequate data were excluded, similar results were found--a 30.4% fall with gemfibrozil and a 4.8% increase with placebo (P < 0.0001). TG levels fell within 4 wk and remained low for 20 wk (P < 0.001). Mean HDL cholesterol rose by 4 wk and increased further at 12 wk (8-12%), P < 0.0001. TC fell. We observed a significant rise in LDL cholesterol in both gemfibrozil- and placebo-treated groups, with no significant differences between these groups. Changes in HbA1c were similar in gemfibrozil and placebo groups. No differences were observed in responses in groups treated with insulin and or oral hypoglycemic drugs. Overall AEs that were clinically important occurred in 6.1% in the gemfibrozil group vs. 2.0% in the placebo group (NS)., Conclusions: We conclude that gemfibrozil is an effective and safe agent in combating the dyslipidemia of NIDDM, irrespective of type of diabetic therapy.
- Published
- 1993
- Full Text
- View/download PDF
23. Vascular thrombosis in type II diabetes mellitus.
- Author
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Colwell JA
- Subjects
- Diabetes Mellitus, Type 2 blood, Fibrinolysis, Humans, Risk Factors, Thrombosis epidemiology, Diabetes Mellitus, Type 2 physiopathology, Diabetic Angiopathies physiopathology, Thrombosis physiopathology
- Published
- 1993
- Full Text
- View/download PDF
24. Oral treatment of diabetes mellitus: the contribution of gliclazide.
- Author
-
Colwell JA
- Subjects
- Humans, Diabetes Mellitus, Type 2 drug therapy, Gliclazide therapeutic use
- Published
- 1991
25. Hemostatic alterations with exercise conditioning in NIDDM.
- Author
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Hornsby WG, Boggess KA, Lyons TJ, Barnwell WH, Lazarchick J, and Colwell JA
- Subjects
- Diabetes Mellitus, Type 2 physiopathology, Enzyme-Linked Immunosorbent Assay, Glucose Tolerance Test, Humans, Male, Middle Aged, Tissue Plasminogen Activator blood, Diabetes Mellitus, Type 2 blood, Fibrinogen analysis, Fibrinolysis, Fibronectins blood, Physical Exertion, Plasminogen analysis
- Abstract
Various parameters of coagulation and fibrinolysis were measured in 13 men (aged 54 +/- 3 yr) with non-insulin-dependent diabetes mellitus (NIDDM) before and after 12-14 wk of exercise training. Subjects exercised for 30 min 3 times/wk at 70% of maximum O2 consumption (VO2max). Training increased VO2max by 12.5% but did not alter body weight, relative body fat, blood pressure, cholesterol, triglycerides, or high-density lipoprotein cholesterol. Slight downward trends were apparent for fasting glucose and insulin, but glycosylated hemoglobin was unchanged. There were no changes in coagulation parameters of plasminogen, hematocrit, or alpha 2-antiplasmin. Plasma fibrinogen (303 +/- 24.2 vs. 256 +/- 12.3 mg/dl) and fibronectin (380 +/- 41.9 vs. 301 +/- 22.2 micrograms/ml) were significantly reduced (P less than 0.02) by exercise conditioning. Three assays of fibrinolytic activity (tissue plasminogen activator, euglobulin lysis time, and an isotopic measure of fibrinolysis) confirmed that neither basal fibrinolysis nor the fibrinolytic responses to venous occlusion and maximal exercise were significantly altered. Exercise conditioning may have antithrombotic effects in NIDDM by reducing plasma fibrinogen and fibronectin. Although the significance of the fall in fibronectin awaits further studies, the reduction in plasma fibrinogen gives a rationale for the use of exercise training in men with NIDDM.
- Published
- 1990
- Full Text
- View/download PDF
26. Veterans Administration Cooperative Study on antiplatelet agents in diabetic patients after amputation for gangrene: II. Effects of aspirin and dipyridamole on atherosclerotic vascular disease rates.
- Author
-
Colwell JA, Bingham SF, Abraira C, Anderson JW, Comstock JP, Kwaan HC, and Nuttall F
- Subjects
- Clinical Trials as Topic, Double-Blind Method, Gangrene etiology, Humans, Male, Middle Aged, Random Allocation, United States, United States Department of Veterans Affairs, Amputation, Surgical, Arteriosclerosis prevention & control, Aspirin therapeutic use, Blood Platelets drug effects, Diabetes Mellitus, Type 2 complications, Diabetic Angiopathies prevention & control, Dipyridamole therapeutic use, Gangrene surgery
- Abstract
We report the results of a randomized multicenter clinical trial on the effects of aspirin plus dipyridamole versus placebo on major vascular end points in 231 non-insulin-dependent diabetic men with either a recent amputation for gangrene or active gangrene. Primary end points were death from atherosclerotic vascular disease plus amputation of the opposite extremity for gangrene. There were 24 atherosclerotic deaths in the drug treatment group (21.8%) and 23 in the placebo group (19.0%). There were 22 patients in the drug treatment group (20.0%) and 29 patients in the placebo group (24.0%) with opposite-side amputations. Survival curve analyses revealed little difference between these groups for major vascular end points, total mortality, all amputations, or myocardial infarctions. The most noteworthy group difference was observed for cerebrovascular end points (strokes and transient ischemic attacks), with an incidence of 8.2% (9 patients) in the drug treatment group and 19.0% (23 patients) in the placebo group. We conclude from this study that antiplatelet agents have no effect on the primary vascular end points, vascular deaths and/or amputation of the opposite extremity, in this population. Similarly, no effects were seen on secondary vascular end points, except for a suggestion of protection versus strokes and transient ischemic attacks. However, this finding must be interpreted with caution, since it is a secondary end point and was found only after multiple analyses of the data.
- Published
- 1986
- Full Text
- View/download PDF
27. V.A. Cooperative Study of antiplatelet agents in diabetic patients after amputation for gangrene: unobserved, sudden, and unexpected deaths.
- Author
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Colwell JA, Bingham SF, Abraira C, Anderson JW, Comstock JP, Kwaan HC, and Nuttall F
- Subjects
- Aspirin therapeutic use, Dipyridamole therapeutic use, Drug Therapy, Combination, Hospitals, Veterans, Humans, Male, Middle Aged, Multicenter Studies as Topic, Myocardial Infarction chemically induced, Myocardial Infarction mortality, Random Allocation, Risk Factors, South Carolina, Amputation, Surgical, Aspirin adverse effects, Death, Sudden, Diabetes Mellitus, Type 2 drug therapy, Dipyridamole adverse effects, Gangrene surgery
- Abstract
We report on unobserved, sudden, and unexpected deaths that occurred in a randomized multicenter trial. The long-term effects of aspirin plus dipyridamole on major vascular outcome variables were studied in 231 non insulin-dependent diabetic men with either a recent amputation for gangrene or active gangrene. Depending upon the definition of sudden death used, there were 14, 22, or 17 deaths in the drug group versus 6, 6, or 3 deaths in the placebo group (p = 0.04, 0.001, or 0.001, respectively). Total deaths from atherosclerotic vascular disease or deaths from all causes did not differ in the two treatment groups. Since this finding of a secondary end point is found only after multiple analyses of the data, it must be interpreted with caution. However, it is suggested that further studies on effects of antiplatelet agents on sudden deaths should be performed.
- Published
- 1989
- Full Text
- View/download PDF
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