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Start Over Author "Stender, S. (Steen)" Topic diabetes
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1. Effects of different protein content and glycemic index of ad libitum diets on diabetes risk factors in overweight adults: the DIOGenes multicentre, randomised, dietary intervention trial

Author

Goyenechea, E. (Estíbaliz), Holst, C. (C.), Saris, W.H.M. (Wim H. M.), Jebb, S.A. (Susan A.), Kafatos, A. (A.), Handjiev, S. (S.), Hlavaty, P. (P.), Stender, S. (Steen), Larsen, T.M. (Thomas M.), Astrup, A. (Arne), and Martinez, J.A. (José Alfredo)

Subjects
Low-glycemic index diets, Weight loss, High-protein diets, Energy restriction, Diabetes, Insulin resistance, Obesity
Abstract

Aims/hypothesis: Diets with different amounts of protein and glycemic index (GI) may be of importance in the control of body weight and metabolic consequences, especially those related to insulin sensitivity. Methods: In DIOGenes, overweight/obese adults in 8 European countries who lost ≥ 8% of initial body-weight (BW) after following a low calorie diet (LCD) were later randomly assigned into five ad libitum interventional groups during 6 months: Low Protein [LP]/Low GI [LGI]; LP/High GI [HGI]; High Protein [HP]/LGI; HP/HGI and a healthy control diet. BW, fasting plasma glucose and insulin as well as an oral glucose tolerance test (OGTT), HOMA-IR, adiponectin and fructosamine levels were determined at the three time points. Results: The LCD period was initiated by 932 adults, 773 were randomised to the 5 diets and 548 completed the intervention. The HP and LGI diets were related to weight-loss management (p

Published
2011

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