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Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To evalute the effects of intraoperative dexmedetomidine in adult patients during recovery periods from general anesthesia after lobectomy. Methods Fifty adult patients undergoing lobectomy were randomized into two groups: control group （Group A，n＝25） and dexmedetomidine group （Group B，n＝25） . No differences in baseline characteristics were observed between the groups. All patients were given propofol and remifentanil for anesthetic induction and maintenance. Ten minutes before the anestheia， patients were given dexmedetomidine （1 μg/kg over 10 minutes followed by a continuous infusion of 0.3 μg/kg/h throughout surgery until 10 minutes before the end of operation） or comparable volumes of saline as a placebo. After the surgery, all patients were sent to the post-anesthetic care unit （PACU） with intubation. The parameters including mean arterial pressure （MAP），heart rate （HR），arterial oxygen pressure （PaO2），bispectral index （BIS），respiratory rate （f），tidal volume （TV），sedation-agitation score （SAS），recovery time，and the stay of PACU were recorded. The times of requiring fentanyl and the VAS score were recorded too．Results （1） The MAP and HR in the group B was significantly lower in group B than that in group A （P<0.05） . （2） The BIS and f in the group B was significantly lower in group B than that in group A （P<0.05）， and the TV and PaO2 in group B was significantly higher than that in group A （P<0.05） （3） The SAS score decreased in the group B compared with the group A （P<0.05）.（4） The VAS score was significantly lower in group B than that in group A （P<0.05）， and in the group B， less patients needed fentanyl after extubation （P<0.05）. Conclusions Intraoperative dexmedetomidine administration can significantly reduce the blood pressure and heart rate in patients undergoing thoracic surgery， improve ventilation during recovery, and decrease the occurrence of agitation and postoperative analgesia during analepsia. [ABSTRACT FROM AUTHOR]

Objective To evaluate the safety and efficacy of dexmedetomidine in adult patients during thoractomy under general anesthesia. Methods Seventy-five adult patients undergoing thoractomy were randomized into two groups ： control group (Group A, n = 36) and dexmedetomidine group (Group B, n = 39). No differences in baseline characteristics were observed between the two groups. All patients received propofol and remifentanil for anesthetic induction and maintenance. Patients were given dexmedetomidine ( 1 μg/kg over 10 minutes followed by a continuous infusion of 0.3 μg/ kg/ h throughout surgery) or comparable volumes of saline as a placebo. The parameters including mean arterial pressure (MAP)，heart rate (HR)，bispectral index (BIS)， sedation-agitation scale (SAS), arterial oxygen pressure (PaO2), arterial oxygen saturation (SaO2) and the stay of post-anesthetic care unit (PACU) were recorded. The doses of propofol, remifentanil, atropine and phenylephrine were recorded too. Results Significantly lower MAP and HR were observed over time in the group B compared with the group A (P < 0.05, 0.01). Patients given dexmedetomidine required less propofol for anesthetic induction and maintenance ( P < 0.05) while required higher dosage of phenylephrine ( P < 0.05) during anesthesia. The SAS scores decreased in the group B (P < 0.05) compared with the group A. Significantly higher PaO2 were observed in the group B than in the group A (P < 0.05 ). Conclusions Dexmedetomidine administration can significantly reduce the requirement for propofol during anesthesia, decrease blood pressure and heart rate in patients undergoing thoractomy, and decrease the occurrence of agitation during analepsia, and also imporve the respiration. [ABSTRACT FROM AUTHOR]