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Your search keyword '"Ivonne, Suridjan"' showing total 20 results
Start Over Author "Ivonne, Suridjan" Topic developmental neuroscience
20 results on '"Ivonne, Suridjan"'

1. Large‐scale proteome and metabolome analysis of CSF implicates altered glucose and carbon metabolism and succinylcarnitine in Alzheimer's disease

Author

Daniel J. Panyard, Justin McKetney, Yuetiva K. Deming, Autumn R. Morrow, Gilda E. Ennis, Erin M. Jonaitis, Carol A. Van Hulle, Chengran Yang, Yun Ju Sung, Muhammad Ali, Gwendlyn Kollmorgen, Ivonne Suridjan, Anna Bayfield, Barbara B. Bendlin, Henrik Zetterberg, Kaj Blennow, Carlos Cruchaga, Cynthia M. Carlsson, Sterling C. Johnson, Sanjay Asthana, Joshua J. Coon, and Corinne D. Engelman

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2023
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2. Test‐retest variability of plasma biomarkers in Alzheimer's disease and its effects on clinical prediction models

Author

Nicholas C. Cullen, Shorena Janelidze, Niklas Mattsson‐Carlgren, Sebastian Palmqvist, Tobias Bittner, Ivonne Suridjan, Alexander Jethwa, Gwendlyn Kollmorgen, Wagner S. Brum, Henrik Zetterberg, Kaj Blennow, Erik Stomrud, and Oskar Hansson

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Abstract

The effect of random error on the performance of blood-based biomarkers for Alzheimer's disease (AD) must be determined before clinical implementation.We measured test-retest variability of plasma amyloid beta (Aβ)42/Aβ40, neurofilament light (NfL), glial fibrillary acidic protein (GFAP), and phosphorylated tau (p-tau)217 and simulated effects of this variability on biomarker performance when predicting either cerebrospinal fluid (CSF) Aβ status or conversion to AD dementia in 399 non-demented participants with cognitive symptoms.Clinical performance was highest when combining all biomarkers. Among single-biomarkers, p-tau217 performed best. Test-retest variability ranged from 4.1% (Aβ42/Aβ40) to 25% (GFAP). This variability reduced the performance of the biomarkers (≈ΔAUC [area under the curve] -1% to -4%) with the least effects on models with p-tau217. The percent of individuals with unstable predicted outcomes was lowest for the multi-biomarker combination (14%).Clinical prediction models combining plasma biomarkers-particularly p-tau217-exhibit high performance and are less effected by random error. Individuals with unstable predicted outcomes ("gray zone") should be recommended for further tests.

Published
2022
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3. Roadmap to implementation of a fully automated blood‐based biomarker test to facilitate diagnosis and treatment in early Alzheimer’s disease

Author

Margherita Carboni, Ivonne Suridjan, Wiesje M. van der Flier, Andreas U. Monsch, Nerida Burnie, Robert Baldor, Marwan N. Sabbagh, Josep Vilaseca, Dongming Cai, Frances‐Catherine Quevenco, Ewelina Golebiewska, and James J. Lah

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022
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4. Associations between semantic memory for proper names in story recall and CSF amyloid and tau in a cognitively unimpaired sample

Author

Madeline R Hale, Rebecca Langhough Koscik, Lianlian Du, Bruce P Hermann, Carol A. Van Hulle, Ivonne Suridjan, Gwendlyn Kollmorgen, Kristin E Basche, Davide Bruno, Leah Sanson‐Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J Betthauser, Sterling C. Johnson, and Kimberly D Mueller

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022
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5. Gut microbe‐modulated metabolites are longitudinally associated with higher neurodegeneration biomarkers in cerebrospinal fluid (CSF)

Author

Margo B. Heston, Cynthia M. Carlsson, Corinne D. Engelman, Erin M. Jonaitis, Carol A. Van Hulle, Yuetiva Deming, Sterling C. Johnson, Sanjay Asthana, Gwendlyn Kollmorgen, Ivonne Suridjan, Norbert Wild, Kaj Blennow, Henrik Zetterberg, Federico E. Rey, and Barbara B. Bendlin

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022
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6. Modifying effect of AD pathology in the association between CSF synaptic biomarkers and brain function and structure in preclinical Alzheimer

Author

Marta Milà‐Alomà, Raffaele Cacciaglia, Mahnaz Shekari, Grégory Operto, Ann Brinkmalm, Hlin Kvartsberg, Nicholas J. Ashton, Gwendlyn Kollmorgen, Norbert Wild, Ivonne Suridjan, Henrik Zetterberg, Kaj Blennow, Jose Luis Molinuevo, Juan Domingo Gispert, and Marc Suárez‐Calvet

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022
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8. Clinical performance and robustness of blood‐based biomarkers for early detection of amyloid pathology associated with Alzheimer’s disease

Author

Kaj Blennow, Hedwig Kurka, Ivonne Suridjan, Alexander Jethwa, Maximilian Hastreiter, Margherita Carboni, Gwendlyn Kollmorgen, Christina Rabe, Tobias Bittner, Christopher Fowler, Colin L. Masters, Henrik Zetterberg, and Oskar Hansson

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022
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9. The Effects of Stressful Life Events on Alzheimer’s Disease Biomarkers, Neuroinflammation and Brain Integrity in Later Life: A Life Course Perspective

Author

Eleni Palpatzis, Muge Akinci, Grégory Operto, Marina Garcia, Kaj Blennow, Henrik Zetterberg, Ivonne Suridjan, Gwendlyn Kollmorgen, Norbert Wild, Juan Domingo Gispert, Marc Suárez‐Calvet, Gonzalo Sánchez‐Benavides, Oriol Grau‐Rivera, Cleofé Peña‐Gomez, and Eider M Arenaza‐Urquijo

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022
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10. An accurate fully automated panel of plasma biomarkers for Alzheimer's disease

Author

Sebastian Palmqvist, Erik Stomrud, Nicholas Cullen, Shorena Janelidze, Ekaterina Manuilova, Alexander Jethwa, Tobias Bittner, Udo Eichenlaub, Ivonne Suridjan, Gwendlyn Kollmorgen, Matthias Riepe, Christine A.F. von Arnim, Hayrettin Tumani, Klaus Hager, Fedor Heidenreich, Niklas Mattsson‐Carlgren, Henrik Zetterberg, Kaj Blennow, and Oskar Hansson

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Abstract

There is a great need for fully automated plasma assays that can measure amyloid beta (Aβ) pathology and predict future Alzheimer's disease (AD) dementia.Two cohorts (n = 920) were examined: Panel A+ (n = 32 cognitively unimpaired [CU], n = 106 mild cognitive impairment [MCI], and n = 89 AD) and BioFINDER-1 (n = 461 CU, n = 232 MCI). Plasma Aβ42/Aβ40, phosphorylated tau (p-tau)181, two p-tau217 variants, ApoE4 protein, neurofilament light, and GFAP were measured using Elecsys prototype immunoassays.The best biomarker for discriminating Aβ-positive versus Aβ-negative participants was Aβ42/Aβ40 (are under the curve [AUC] 0.83-0.87). Combining Aβ42/Aβ40, p-tau181, and ApoE4 improved the AUCs significantly (0.90 to 0.93; P 0.01). Adding additional biomarkers had marginal effects (ΔAUC ≤0.01). In BioFINDER, p-tau181, p-tau217, and ApoE4 predicted AD dementia within 6 years in CU (AUC 0.88) and p-tau181, p-tau217, and Aβ42/Aβ40 in MCI (AUC 0.87).The high accuracies for Aβ pathology and future AD dementia using fully automated instruments are promising for implementing plasma biomarkers in clinical trials and clinical routine.

Published
2022

11. Amyloid time: Quantifying the onset of abnormal biomarkers and cognitive impairment along the Alzheimer’s disease continuum

Author

Tobey J. Betthauser, Rebecca L. Koscik, Erin M. Jonaitis, Carol A. Van Hulle, Kristin E. Basche, Akshay Kohli, Ivonne Suridjan, Gwendlyn Kollmorgen, Nathaniel A. Chin, Kimberly D. Mueller, Lindsay R. Clark, Bradley T. Christian, Ozioma C. Okonkwo, Barbara B. Bendlin, Sanjay Asthana, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, and Sterling C. Johnson

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021
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12. Amyloid status is associated with deficits in connected speech language

Author

Carol A. Van Hulle, Erin M. Jonaitis, Tobey J. Betthauser, Gwendlyn Kollmorgen, Ivonne Suridjan, Ulf Andreasson, Cynthia M. Carlsson, Sanjay Asthana, Sterling C. Johnson, Henrik Zetterberg, Kaj Blennow, and Kimberly D. Mueller

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021
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13. CSF sphingomyelin metabolites in Alzheimer’s disease, neurodegeneration, and neuroinflammation

Author

Autumn Rose Morrow, Daniel J. Panyard, Yuetiva Deming, Ruocheng Dong, Eva Vasiljevic, Tobey J. Betthauser, Erin M. Jonaitis, Gwendlyn Kollmorgen, Ivonne Suridjan, Henrik Zetterberg, Kaj Blennow, Carol A. Hulle, Cynthia M. Carlsson, Sanjay Asthana, Sterling C. Johnson, and Corinne D. Engelman

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021
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14. CSF amyloid, tau, and neurodegeneration biomarkers are associated with longitudinal cognitive decline in preclinical AD

Author

Karly Alex Cody, Tobey J. Betthauser, Carol A. Hulle, Rebecca L. Koscik, Erin M. Jonaitis, Lindsay R. Clark, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Sanjay Asthana, Ivonne Suridjan, Gwendlyn Kollmorgen, Henrik Zetterberg, Cynthia M. Carlsson, Kaj Blennow, and Sterling C. Johnson

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021
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15. Effects of APOE genotype, age and sex on cerebrospinal fluid biomarkers measured with NeuroToolKit in the Longitudinal Swedish Biofinder Cohort

Author

Claudia Cicognola, Shorena Janelidze, Sebastian Palmqvist, Ivonne Suridjan, Gwendlyn Kollmorgen, Niklas Mattsson‐Carlgren, and Oskar Hansson

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021
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16. Diet and APOE as moderators of the relationship between trimethylamine N‐oxide and biomarkers of Alzheimer's disease and glial activation

Author

John C. Thorstenson, Margo B. Heston, Katie R Zarbock, Cynthia M Carlsson, Corinne D. Engelman, Yuetiva Deming, Sterling C. Johnson, Tyler K. Ulland, Sanjay Asthana, Gwendlyn Kollmorgen, Ivonne Suridjan, Kaj Blennow, Henrik Zetterberg, Nathaniel A Chin, Federico E. Rey, and Barbara B Bendlin

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021
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17. CSF metabolites associated with CSF NeuroToolKit biomarkers

Author

Ruocheng Dong, Qiongshi Lu, Ivonne Suridjan, Gwendlyn Kollmorgen, Kaj Blennow, Henrik Zetterberg, Cynthia M. Carlsson, Sanjay Asthana, Sterling C. Johnson, and Corinne D. Engelman

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021
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18. Associations between obstructive sleep apnea, Alzheimer’s disease pathology, and objective daytime sleepiness measured by the psychomotor vigilance task in cognitively unimpaired adults

Author

David T Plante, Kieulinh Michelle Tran, Jesse D Cook, Erika W Hagen, Paul E Peppard, Gwendlyn Kollmorgen, Ivonne Suridjan, Kaj Blennow, Henrik Zetterberg, Cynthia M Carlsson, Sterling C. Johnson, and Barbara B Bendlin

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021
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19. Data‐driven approach for early detection of pathological pathways in middle‐aged adults with family history of sporadic Alzheimer’s disease

Author

Cleofé Peña‐Gomez, Muge Akinci, Gonzalo Sánchez‐Benavides, Mahnaz Shekari, Oriol Grau‐Rivera, Grégory Operto, Marta Milà‐Alomà, Aleix Sala‐Vila, Gemma Salvadó, Gwendlyn Kollmorgen, Ivonne Suridjan, Kaj Blennow, Henrik Zetterberg, Jose Molinuevo, Juan Domingo Gispert, Marc Suarez‐Calvet, and Eider M Arenaza‐Urquijo

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021
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20. P4‐164: Mapping neuroinflammation in vivo in healthy aging and Alzheimer's disease: A PET study using a novel translocator protein 18kDA (TSPO) radioligand, [18F]‐FEPPA

Author

Houle Sylvain, Bruce G. Pollock, Ivonne Suridjan, Rusjan Pablo, Romina Mizrahi, Alan A. Wilson, and Aristotle N. Voineskos

Subjects
biology, Epidemiology, business.industry, Health Policy, Disease, Pharmacology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, In vivo, Radioligand, Translocator protein, biology.protein, Medicine, Neurology (clinical), Geriatrics and Gerontology, Healthy aging, business, Neuroinflammation
Published
2012
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