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Your search keyword '"Sottocornola, Roberta"' showing total 2 results
Start Over Author "Sottocornola, Roberta" Topic developmental biology
2 results on '"Sottocornola, Roberta"'

1. The tumour suppressor ASPP2 plays a novel role in the maintenance of epithelial cell polarity

Author

Sottocornola, Roberta and Lu, Xin

Subjects
616.994027, cell biology, developmental biology, tumour suppressor, epithelial polarity, CNS development
Abstract

ASPP2 has been identified as a haploinsufficient tumour suppressor in mice, and an activator of the apoptotic function of the p53 family. Yeast two-hybrid experiments have also shown that ASPP2 interacts with a large number of proteins involved in other major signalling pathways. The mechanism(s) of action of ASPP2 are therefore complex, and likely to involve more than just the stimulation of the apoptotic programme. Since a study previously conducted in our laboratory revealed that the deletion of ASPP2 in vivo leads to severe hydrocephalus in the J129/C57BL6 background (Vives et al., 2006), it can be hypothesised that ASPP2 safeguards the normal development of the mammalian central nervous system (CNS), in addition to its role as a tumour suppressor. Deletion of ASPP2 leads to the development of hydrocephalus, most probably by affecting tight junctions (TJs) in the choroid plexus, thereby impairing its blood-cerebrospinal fluid (CSF) barrier function. TJ defects are likely to be the underlying cause of the loss of cell polarity observed in the neuroepithelium of several areas of the CNS. As cell polarity plays a key role in multiple aspects of CNS development, ASPP2 appears to be required for the proper lamination of the cerebral cortex and retina.

Published
2010

2. Dynamic expression of the p53 family members p63 and p73 in the mouse and human telencephalon during development and in adulthood

Author

Hernández-Acosta, N. Carolina, Cabrera-Socorro, Alfredo, Morlans, Mercedes Pueyo, Delgado, Francisco J. González, Suárez-Solá, M. Luisa, Sottocornola, Roberta, Lu, Xin, González-Gómez, Miriam, and Meyer, Gundela

Subjects
*P53 antioncogene, *GENE expression, *TELENCEPHALON, *ADULTS, *DEVELOPMENTAL biology, *LABORATORY mice, *HIPPOCAMPUS (Brain), *TRANSCRIPTION factors
Abstract

Abstract: p63 and p73, family members of the tumor suppressor p53, are critically involved in the life and death of mammalian cells. They display high homology and may act in concert. The p73 gene is relevant for brain development, and p73-deficient mice display important malformations of the telencephalon. In turn, p63 is essential for the development of stratified epithelia and may also play a part in neuronal survival and aging. We show here that p63 and p73 are dynamically expressed in the embryonic and adult mouse and human telencephalon. During embryonic stages, Cajal-Retzius cells derived from the cortical hem co-express p73 and p63. Comparison of the brain phenotypes of p63- and p73- deficient mice shows that only the loss of p73 function leads to the loss of Cajal-Retzius cells, whereas p63 is apparently not essential for brain development and Cajal-Retzius cell formation. In postnatal mice, p53, p63, and p73 are present in cells of the subventricular zone (SVZ) of the lateral ventricle, a site of continued neurogenesis. The neurogenetic niche is reduced in size in p73-deficient mice, and the numbers of young neurons near the ventricular wall, marked with doublecortin, Tbr1 and calretinin, are dramatically decreased, suggesting that p73 is important for SVZ proliferation. In contrast to their restricted expression during brain development, p73 and p63 are widely detected in pyramidal neurons of the adult human cortex and hippocampus at protein and mRNA levels, pointing to a role of both genes in neuronal maintenance in adulthood. [ABSTRACT FROM AUTHOR]

Published
2011
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