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It has been well established that Chlamydia trachomatis screening among women in most settings is cost-effective.1–8 Populations studied have included women attending family planning clinics,2–5 sexually transmitted disease (STD) clinics,4 emergency departments,1 youth clinics,5 gynecology clinics,5 student health centers,3 and military recruits6,7 and population based screening of 15- to 29-year-old women.8 Most of the analyses assumed asymptomatic status of women.3,5–8 Two analyses, however, compared several strategies, with some of the strategies taking symptom status into account and others screening everyone the same way regardless of symptom status.1,2 Many analyses took the health care system perspective.1–3,5 However, 2 conducted analyses from the military perspective,6,7 and 2 used the societal perspective.4,8 In most previous analyses, either an endocervical specimen was tested4,5 or a urine specimen was tested.1,3,6–8 Consequently, many previous analyses did not evaluate the impact of omitting the speculum examination on the cost-effectiveness outcome.1,3–7 The Aptima Combo 2 (AC2) test is among a new generation of tests that use nucleic acid amplification and is FDA-cleared for use on endocervical, urine, and vaginal specimens. Because most Chlamydia infections are asymptomatic,9–12 many women who seek screening have no symptoms. Unless they are due for an annual Papanicolaou (Pap) smear, asymptomatic women who are screened with a vaginal or urine AC2 test do not require a speculum examination, omission of which can save time and money. The objective of this study was to evaluate the cost-effectiveness of several Chlamydia screening strategies and to incorporate conditions where a speculum examination may not be necessary.

The purpose of this study was to investigate the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium, in women attending a sexually transmitted disease (STD) clinic, as well as the frequency of coinfections, and relationship of each organism to cervicitis.In this cross-sectional study of 324 women attending Baltimore City STD Clinics, C. trachomatis, N. gonorrhoeae, T. vaginalis, and M. genitalium were detected using nucleic acid amplification tests. Demographic characteristics and risk factors were ascertained.Overall prevalence of infection with C. trachomatis, N. gonorrhoeae, T. vaginalis, and M. genitalium was found to be 11.1%, 4.6%, 15.3%, and 19.2%, respectively. Prevalence in women with cervicitis was 15.8%, 6%, 18.9%, and 28.6% for C. trachomatis, N. gonorrhoeae, T. vaginalis, and M. genitalium, respectively. Percentages of coinfections were high. C. trachomatis and M. genitalium were significantly associated with cervicitis in univariate analysis, but only M. genitalium was significantly associated with cervicitis (AOR: 2.5) in multiple logistic regression models.Knowledge of the statistical association of M. genitalium with cervicitis in this study increases the need for further confirmation of the etiologic significance of this organism with cervicitis in more diverse populations. The high prevalence merits more study and may have implications for diagnosis and treatment of cervicitis.

Objectives: To investigate prevalence of Mycoplasma genitalium, Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis in men, frequency of co-infections, and association of organisms with urethritis in men. Methods: This was a cross-sectional study of 290 men (age range 19–34 years) attending Baltimore City STD clinics. M genitalium, C trachomatis, N gonorrhoeae and T vaginalis, during 2004 were detected using nucleic acid amplification tests (NAATs) (153 with urethritis and 137 without urethritis). Demographic characteristics and risk factors were ascertained. Results: The overall prevalences of infection with C trachomatis, N gonorrhoeae, T vaginalis and M genitalium were 20.3%, 12.8%, 3.4% and 15.2%, respectively. Prevalences in men with urethritis were 32.7%, 24.2%, 5.2% and 22.2% for C trachomatis, N gonorrhoeae, T vaginalis and M genitalium, respectively. Percentages of co-infections were high. All men with N gonorrhoeae had urethritis. C trachomatis and M genitalium were found to be significantly associated with urethritis in univariate analysis and in multiple logistic regression analysis. Conclusion: The association of M genitalium with urethritis in this study provides confirmation of the importance of screening men for M genitalium as a cause of non-gonococcal urethritis and supports treatment considerations for urethritis for agents other than gonococci and chlamydia.