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Background: Sensitization to allergens in atopic dermatitis patients is a risk factor for developing asthma and allergic rhinitis in the future, as well as an aggravating factor in the course of the disease. Recent studies have attributed the activity of the proteases of some antigens to cause a grater defect in the epithelial barrier and a more severe disease. Objectives: To know the sensitization to allergens pattern in children with atopic dermatitis attended at Allergology Service of University Hospital of UANL, Mexico, and to know if these children have higher sensitization to antigens with proteolytic activity. Material and method: A retrospective study was done reviewing the skin prick test reports done in our service to children ranging from 5 months to 1 6 years old, diagnosed with atopic dermatitis during a period of 2 years, from January 2012 to January 2014. The frequency of sensitization to aeroallergens and food were analyzed as well as the weal size (≥6mm) on the skin in response to each particular allergen in the case of food skin prick test. Results: Reports of skin tests of 66 children, 30 boys and 36 girls, were included; 37 of children were sensitized to more than one allergen, 18/66 had asthma and/or allergic rhinitis, 40/66 60% skin prick tests were positive to high activity protease aeroallergens (Dermatophagoides pteronyssinus/Dermatophagoides farinae). Regarding food, sensitization was seen in 38 children; fruits and vegetables were the two most common foods. Only seven children had skin prick weal bigger than 6 mm, mainly to egg, fish and cow's milk. Conclusion: Children with atopic dermatitis are often sensitized to high protease activity aeroallergens, polysensitization is very common and the association with airway allergy is seen early in life. Sensitization to food is also common in these patients, but only a small percentage showed a response large enough to be associated with disease severity. [ABSTRACT FROM AUTHOR]

Background: Several international guidelines on immunotherapy exist, but they only apply partially in Mexico. The Mexican guideline of immunotherapy dates from 1998. Objectives: To establish clinical recommendations and suggestions for Allergy residents and specialists for skin testing and allergen immunotherapy based on evidence and Mexican expert opinion, according to the GRADE system. Methods: The guidelines were developed following the methodology of a guideline for clinical practice starting with the formulation of clinical questions, in the context of Mexican environmental conditions and morbidity, with the participation of allergists from all regions of the country. External validation was obtained. Its development followed three steps: 1. formulation of 24 clinical questions. 2. Search for consensus on the answers among members of the Regional chapters of both Mexican Colleges of Allergists (CMICA and COMPEDIA) during regional meetings. 3. Literature search for articles related to the questions and grading of its quality according to GRADE. Results: Based on the regional consensus, 116 articles and the safety, patient acceptance/ comfort and cost clinical recommendations and suggestions were developed on basic aspects of skin testing, subcutaneous and sublingual immunotherapy (patient preparation, vial preparation and application schedules) and the treatment of eventual adverse reactions. Conclusions: A clinical guideline was developed respecting particular methodology, validated by CMICA and COMPEDIA for its implementation among Mexican allergists. Several aspects deserve further study to improve scientific evidence. [ABSTRACT FROM AUTHOR]

Background: Atopic dermatitis is an ever more frequent disease in children; its etiology is unknown, although a genetic predisposition along with environment factors could be the origin. Objective: To determine the prevalence of atopic dermatitis among school-children and the main associated risk factors. Patients and methods: A randomized, stratified and conglomerated sample of 6 to 12 year-old school-children was obtained. Their parents answered the main ISAAC questionnaire, to which some variables were added, such as family and hereditary history, tobaccosmoking exposure and nutritional condition according to the body mass index as associated risk factors. Results: We found a prevalence of 3% for atopic dermatitis, and the presence of dermatitis symptoms during the last twelve months was found in 6.8% of the cases. Multivariate analysis demonstrated an elevated risk for atopic dermatitis in children of mothers with any type of allergic disease (OR 2.75, CI 95% 1.09 to 6.92, p = 0.031). Conclusions: The frequency of atopic dermatitis as well as that of the symptoms was low, similar to previous reports conducted in Mexico. Maternal atopy was the only factor associated with atopic dermatitis. [ABSTRACT FROM AUTHOR]

Background: Atopic dermatitis is a frequent chronic dermatosis in children. Objective: To determine the prevalence of atopic dermatitis in a pediatric population from Morelia, Michoacan. Participants and methods: An observational, descriptive and comparative study was done to estimate the prevalence and underdiagnosis of atopic dermatitis in children and teenagers from Morelia, Michoacan (n = 9578). This study had a sensitivity of 0.87 and a specificity of 0.92. Results: A prevalence of 10.1% and 5.4% was found in children from 6 to 10 years old and teenagers from 11 to 16 years old. The diagnosis was done in only 20% of all cases. The high underdiagnosis suggests taking emergent actions of preventive medicine. Conclusions: The prevalence of atopic dermatitis in pediatric population from Morelia is similar of that reported in the United States and less than of Mexico City. [ABSTRACT FROM AUTHOR]