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Type I hypersensitivity reactions have been described after solid organ transplantation despite T cell targeted immunosuppressive therapy. There are several reports of food allergy, asthma and eosinophilic colitis in pediatric transplant recipients under Tacrolimus immunosuppression, but not Cyclosporine A. We present the case of a 6 year old patient that developed de novo atopic dermatitis, eosinophilia and high levels of total IgE under systemic treatment with tacrolimus.