1. Does lithium reduce the mortality of recurrent mood disorders?
- Author
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Coppen A, Standish-Barry H, Bailey J, Houston G, Silcocks P, and Hermon C
- Subjects
- Bipolar Disorder psychology, Cross-Sectional Studies, Depressive Disorder psychology, England epidemiology, Follow-Up Studies, Humans, Incidence, Psychotic Disorders psychology, Recurrence, Suicide psychology, Wales epidemiology, Bipolar Disorder drug therapy, Bipolar Disorder mortality, Cause of Death, Depressive Disorder drug therapy, Depressive Disorder mortality, Lithium Carbonate therapeutic use, Psychotic Disorders drug therapy, Psychotic Disorders mortality, Suicide statistics & numerical data, Suicide Prevention
- Abstract
Numerous follow-up studies have shown that patients with mood disorders who do not receive prophylactic medication are at increased risk of death, particularly from suicide. After 11 years follow-up we compared the mortality of 103 patients attending a lithium clinic with that expected on the basis of age/sex/year-specific rates for England and Wales. Only 10 patients died during the study, although the expected number of deaths was 18.31 (P = 0.052, two-tailed) and no deaths from suicide were observed. After correcting for the prevalence of mood disorder in the general population, the relative risk was 0.60 (95% CI 0.29-1.12) which suggests that lithium reverses the excess mortality associated with recurrent mood disorders, including that from suicide.
- Published
- 1991
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