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The article discusses the study that aims to determine whether the new onset depression is associated with menopausal transition and hormonal changes within individual women. Information on the design of the study, the setting and date the study was conducted, and the covered population were also provided.

The article discusses finding of a research which suggests that depression increases in women during early to late menopause but decreases after menopause. Although there is suggestive evidence from observational studies that oestrogen therapy improves mood and cognition, the clinical relevance of oestrogens is unproved. There are weak data that oestrogens might be considered for mild depressive symptoms attributed to hot flushes, sleep disorder or climacteric symptoms. No hard data exist to indicate whether oestrogens could be used as adjunctive therapy for other depressive disorders during the menopausal transition.