63 results
Search Results
2. Pregnant Women's Views on the Feasibility and Acceptability of Web-Based Mental Health E-Screening Versus Paper-Based Screening: A Randomized Controlled Trial.
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Kingston D, Austin MP, Veldhuyzen van Zanten S, Harvalik P, Giallo R, McDonald SD, MacQueen G, Vermeyden L, Lasiuk G, Sword W, and Biringer A
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- Adult, Feasibility Studies, Female, Humans, Mass Screening methods, Mental Health, Paper, Pregnancy Complications psychology, Anxiety diagnosis, Depression diagnosis, Internet, Patient Acceptance of Health Care psychology, Pregnancy psychology, Telemedicine methods
- Abstract
Background: Major international guidelines recommend mental health screening during the perinatal period. However, substantial barriers to screening have been reported by pregnant and postpartum women and perinatal care providers. E-screening offers benefits that may address implementation challenges., Objective: The primary objective of this randomized controlled trial was to evaluate the feasibility and acceptability of Web-based mental health e-screening compared with paper-based screening among pregnant women. A secondary objective was to identify factors associated with women's preferences for e-screening and disclosure of mental health concerns., Methods: Pregnant women recruited from community and hospital-based antenatal clinics and hospital-based prenatal classes were computer-randomized to a fully automated Web-based e-screening intervention group or a paper-based control group. Women were eligible if they spoke or read English, were willing to be randomized to e-screening, and were willing to participate in a follow-up diagnostic interview. The intervention group completed the Antenatal Psychosocial Health Assessment and the Edinburgh Postnatal Depression Scale on a tablet computer, while controls completed them on paper. All women completed self-report baseline questions and were telephoned 1 week after randomization by a blinded research assistant for a MINI International Neuropsychiatric Interview. Renker and Tonkin's tool of feasibility and acceptability of computerized screening was used to assess the feasibility and acceptability of e-screening compared with paper-based screening. Intention-to-treat analysis was used. To identify factors associated with preference for e-screening and disclosure, variables associated with each outcome at P<.20 were simultaneously entered into final multivariable models to estimate adjusted odds ratios (AORs) and 95% CIs., Results: Of the 675 eligible women approached, 636 agreed to participate (participation rate 94.2%) and were randomized to the intervention (n=305) or control (n=331) groups. There were no significant baseline differences between groups. More women in the e-screening group strongly or somewhat agreed that they would like to use a tablet for answering questions on emotional health (57.9%, 175/302 vs 37.2%, 121/325) and would prefer using a tablet to paper (46.0%, 139/302 vs 29.2%, 95/325), compared with women in the paper-based screening group. There were no differences between groups in women's disclosure of emotional health concerns (94.1%, 284/302 vs 90.2%, 293/325). Women in the e-screening group consistently reported the features of e-screening more favorably than controls (more private or confidential, less impersonal, less time-consuming). In the multivariable models, being in the e-screening group was significantly associated with preferring e-screening (AOR 2.29, 95% CI 1.66-3.17), while no factors were significantly associated with disclosure., Conclusions: The findings suggest that mental health e-screening is feasible and acceptable to pregnant women., Trial Registration: Clinicaltrials.gov NCT01899534; https://clinicaltrials.gov/ct2/show/NCT01899534 (Archived by WebCite at http://www.webcitation.org/6ntWg1yWb)., (©Dawn Kingston, Marie-Paule Austin, Sander Veldhuyzen van Zanten, Paula Harvalik, Rebecca Giallo, Sarah D McDonald, Glenda MacQueen, Lydia Vermeyden, Gerri Lasiuk, Wendy Sword, Anne Biringer. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 07.04.2017.)
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- 2017
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3. Comparison of Internet-based and paper-based questionnaires in Taiwan using multisample invariance approach.
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Yu SC and Yu MN
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- Depression ethnology, Humans, Language, Models, Psychological, Psychometrics, Taiwan, Depression diagnosis, Internet, Paper, Research, Surveys and Questionnaires
- Abstract
This study examines whether the Internet-based questionnaire is psychometrically equivalent to the paper-based questionnaire. A random sample of 2,400 teachers in Taiwan was divided into experimental and control groups. The experimental group was invited to complete the electronic form of the Chinese version of Center for Epidemiologic Studies Depression Scale (CES-D) placed on the Internet, whereas the control group was invited to complete the paper-based CES-D, which they received by mail. The multisample invariance approach, derived from structural equation modeling (SEM), was applied to analyze the collected data. The analytical results show that the two groups have equivalent factor structures in the CES-D. That is, the items in CES-D function equivalently in the two groups. Then the equality of latent mean test was performed. The latent means of "depressed mood," "positive affect," and "interpersonal problems" in CES-D are not significantly different between these two groups. However, the difference in the "somatic symptoms" latent means between these two groups is statistically significant at alpha = 0.01. But the Cohen's d statistics indicates that such differences in latent means do not apparently lead to a meaningful effect size in practice. Both CES-D questionnaires exhibit equal validity, reliability, and factor structures and exhibit a little difference in latent means. Therefore, the Internet-based questionnaire represents a promising alternative to the paper-based questionnaire.
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- 2007
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4. Mode effects in the center for epidemiologic studies depression (CES-D) scale: personal digital assistant vs. paper and pencil administration.
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Swartz RJ, de Moor C, Cook KF, Fouladi RT, Basen-Engquist K, Eng C, and Carmack Taylor CL
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- Adult, Aged, Aged, 80 and over, Communication, Cross-Over Studies, Depression diagnosis, Depression epidemiology, Female, Humans, Male, Middle Aged, Surveys and Questionnaires classification, Computers, Handheld, Depression psychology, Paper, Psychometrics instrumentation, Quality of Life psychology, Sickness Impact Profile, Surveys and Questionnaires standards, Writing
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As interest grows in creating computerized versions of established paper-and-pencil (P&P) questionnaires, it becomes increasingly important to explore whether changing the administration modes of questionnaires affects participants' responses. This study investigated whether mode effects exist when administering the Center for Epidemiologic Studies Depression (CES-D) scale by a personal digital assistant (PDA) versus the classic P&P mode. The Differential Functioning of Items and Tests (DFIT) procedure identified mode effects on the overall test and individual items. A mixed-effects regression model summarized the mode effects in terms of CES-D scores, and identified interactions with covariates. When the P&P questionnaire was administered first, scores were higher on average (2.4-2.8 points) than those of the other administrations (PDA second, PDA first, and P&P second), and all 20 questionnaire items exhibited a statistically significant mode effect. Highly educated people and younger people demonstrated a smaller difference in scores between the two modes. The mode-by-order effect influenced the interpretation of CES-D scores, especially when screening for depression using the established cut-off scores. These results underscore the importance of evaluating the cross-mode equivalence of psychosocial instruments before administering them in non-established modes.
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- 2007
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5. Prevalence of pain and its association with symptoms of post‐traumatic stress disorder, depression, anxiety and distress in 846 cancer patients: A cross sectional study
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Feroniki Adamidis, Matthäus Fellinger, Matthias Unseld, Ulrich Jäger, Anna Kitta, Simone Lubowitzki, Eva Katharina Masel, Matthias Hafner, Alexander Gaiger, Matthias Preusser, Katharina Krammer, Elisabeth L. Zeilinger, and Ingo W. Nader
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Paper ,Biopsychosocial model ,medicine.medical_specialty ,Visual analogue scale ,Cross-sectional study ,Pain ,Experimental and Cognitive Psychology ,Anxiety ,Stress Disorders, Post-Traumatic ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,Prevalence ,cancer ,Humans ,Medicine ,030212 general & internal medicine ,Depression (differential diagnoses) ,post‐traumatic stress disorder ,clinical oncology ,symptom assessment ,Depression ,business.industry ,Traumatic stress ,Mental health ,mental disorders ,outpatients ,Psychiatry and Mental health ,Distress ,Cross-Sectional Studies ,Oncology ,psycho‐oncology ,030220 oncology & carcinogenesis ,Papers ,Physical therapy ,Female ,medicine.symptom ,business - Abstract
Objective Pain depicts a severe physical symptom but its relationship to mental health problems is not well studied in cancer patients. The aim of this study was to investigate the prevalence of pain and its correlation with symptoms of post-traumatic stress disorder (PTSD), depression, anxiety, and psychological distress in a large sample of cancer patients. Methods From 2010 to 2019, cancer patients who received outpatient treatment at the Medical University of Vienna, were assessed with the Post-Traumatic Symptom Scale (PTSS-10) and the Hospital Anxiety and Depression Scales (HADS). A visual analogue scale was used to assess pain perception. For statistical analysis, linear regression models were applied to log-transformed data. Results Of the 846 cancer patients included in the study, 63.5% experienced pain (mild 43.5%, moderate 13.6%, severe 6.4%). About a third (31,2%) of the total sample presented with significant PTSD symptoms. Significant symptoms of depression, anxiety, and distress were present in 13.9%, 15.1%, and 25.3%, respectively. Women more often reported symptoms of PTSD, anxiety, and distress. Pain scores were significantly related to symptoms of PTSD, depression and psychological distress (all with p Conclusions Results show a high prevalence of experienced pain and indicate a clear association of elevated pain levels with psychiatric symptoms in oncological patients in a large Austrian sample. In order to decrease experienced pain and to enable better treatment of mental health problems in cancer patients, diagnostic procedures and interventions based on a biopsychosocial model need to be intensified. This article is protected by copyright. All rights reserved.
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- 2020
6. Educational attainment trajectories among children and adolescents with depression, and the role of sociodemographic characteristics: longitudinal data-linkage study
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Alice Wickersham, Johnny Downs, Hannah Dickson, Rebecca M. Jones, Megan Pritchard, Robert Stewart, Tamsin Ford, Ford, Tamsin Jane [0000-0001-5295-4904], and Apollo - University of Cambridge Repository
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Paper ,Male ,Depressive disorders ,Adolescent ,Population ,Ethnic group ,03 medical and health sciences ,0302 clinical medicine ,London ,cohort study ,trajectories ,Humans ,Medicine ,0501 psychology and cognitive sciences ,Longitudinal Studies ,030212 general & internal medicine ,Child ,education ,Socioeconomic status ,Depression (differential diagnoses) ,education.field_of_study ,Schools ,Academic year ,Depression ,business.industry ,05 social sciences ,Repeated measures design ,Educational attainment ,childhood and adolescence ,Psychiatry and Mental health ,Educational Status ,business ,education and training ,050104 developmental & child psychology ,Demography ,Cohort study - Abstract
BackgroundDepression is associated with lower educational attainment, but there has been little investigation of long-term educational trajectories in large cohorts with diagnosed depression.AimsTo describe the educational attainment trajectories of children with a depression diagnosis in secondary care, and to investigate whether these trajectories vary by sociodemographic characteristics.MethodWe identified new referrals to South London and Maudsley's NHS Foundation Trust between 2007 and 2013 who received a depression diagnosis at under 18 years old. Linking their health records to the National Pupil Database, we standardised their performance on three assessments (typically undertaken at ages 6–7 years (school Year 2), 10–11 (Year 6) and 15–16 (Year 11)) relative to the local reference population in each academic year. We used mixed models for repeated measures to estimate attainment trajectories.ResultsIn our sample of 1492 children, the median age at depression diagnosis was 15 years (interquartile range = 14–16). Their attainment showed a decline between school Years 6 and 11. Attainment was consistently lower among males and those eligible for free school meals. Black ethnic groups also showed lower attainment than White ethnic groups between Years 2 and 6, but showed a less pronounced drop in attainment at Year 11.ConclusionsThose who receive a depression diagnosis during their school career show a drop in attainment in Year 11. Although this pattern was seen among multiple sociodemographic groups, gender, ethnicity and socioeconomic status predict more vulnerable subgroups within this clinical population who might benefit from additional educational support or more intensive treatment.
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- 2020
7. Time use and mental health in UK adults during an 11-week COVID-19 lockdown: a panel analysis
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Andrew Steptoe, Daisy Fancourt, Hei Wan Mak, and Feifei Bu
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Paper ,Adult ,Isolation (health care) ,PsycINFO ,03 medical and health sciences ,0302 clinical medicine ,Environmental health ,Pandemic ,medicine ,Humans ,030212 general & internal medicine ,life satisfaction ,Pandemics ,Depression (differential diagnoses) ,SARS-CoV-2 ,Life satisfaction ,COVID-19 ,anxiety ,Mental health ,United Kingdom ,Psychiatry and Mental health ,Panel analysis ,Mental Health ,depression ,Communicable Disease Control ,Anxiety ,medicine.symptom ,Psychology ,Time use ,030217 neurology & neurosurgery - Abstract
BackgroundThere is currently major concern about the impact of the global COVID-19 outbreak on mental health. But it remains unclear how individual behaviours could exacerbate or protect against adverse changes in mental health.AimsTo examine the associations between specific activities (or time use) and mental health and well-being among people during the COVID-19 pandemic.MethodData were from the UCL COVID-19 Social Study, a panel study collecting data weekly during the COVID-19 pandemic. The analytical sample consisted of 55 204 adults living in the UK who were followed up for the 11-week strict lockdown period from 21 March to 31 May 2020. Data were analysed using fixed-effects and Arellano–Bond models.ResultsChanges in time spent on a range of activities were associated with changes in mental health and well-being. After controlling for bidirectionality, behaviours involving outdoor activities such as gardening and exercising predicted subsequent improvements in mental health and well-being, whereas increased time spent following news about COVID-19 predicted declines in mental health and well-being.ConclusionsThese results are relevant to the formulation of guidance for people obliged to spend extended periods in isolation during health emergencies and may help the public to maintain well-being during future lockdowns and pandemics.
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- 2022
8. Association between air pollution exposure and mental health service use among individuals with first presentations of psychotic and mood disorders: retrospective cohort study
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Ryan Hammoud, Megan Pritchard, Joanne B. Newbury, Margaret Heslin, Stephani L. Hatch, Sean Beevers, Robert Stewart, Matthew Broadbent, Narushige Shiode, Helen L. Fisher, Ian Mudway, Ioannis Bakolis, Matthew Hotopf, and David Dajnak
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Paper ,Mental Health Services ,Air pollution exposure ,Nitrogen Dioxide ,Mental health service ,Recurrence ,Environmental health ,psychotic disorders ,Air Pollution ,medicine ,cohort study ,Humans ,Association (psychology) ,11 Medical and Health Sciences ,Retrospective Studies ,Psychiatry ,RISK ,Air Pollutants ,Science & Technology ,business.industry ,Mood Disorders ,LIFETIME PREVALENCE ,Mental Disorders ,COST ,illness severity and relapse ,Retrospective cohort study ,Environmental Exposure ,medicine.disease ,DEPRESSION ,17 Psychology and Cognitive Sciences ,Psychiatry and Mental health ,Mood disorders ,Particulate Matter ,business ,Life Sciences & Biomedicine ,Cohort study - Abstract
BackgroundGrowing evidence suggests that air pollution exposure may adversely affect the brain and increase risk for psychiatric disorders such as schizophrenia and depression. However, little is known about the potential role of air pollution in severity and relapse following illness onset.AimsTo examine the longitudinal association between residential air pollution exposure and mental health service use (an indicator of illness severity and relapse) among individuals with first presentations of psychotic and mood disorders.MethodWe identified individuals aged ≥15 years who had first contact with the South London and Maudsley NHS Foundation Trust for psychotic and mood disorders in 2008–2012 (n = 13 887). High-resolution (20 × 20 m) estimates of nitrogen dioxide (NO2), nitrogen oxides (NOx) and particulate matter (PM2.5 and PM10) levels in ambient air were linked to residential addresses. In-patient days and community mental health service (CMHS) events were recorded over 1-year and 7-year follow-up periods.ResultsFollowing covariate adjustment, interquartile range increases in NO2, NOx and PM2.5 were associated with 18% (95% CI 5–34%), 18% (95% CI 5–34%) and 11% (95% CI 3–19%) increased risk for in-patient days after 1 year. Similarly, interquartile range increases in NO2, NOx, PM2.5 and PM10 were associated with 32% (95% CI 25–38%), 31% (95% CI 24–37%), 7% (95% CI 4–11%) and 9% (95% CI 5–14%) increased risk for CMHS events after 1 year. Associations persisted after 7 years.ConclusionsResidential air pollution exposure is associated with increased mental health service use among people recently diagnosed with psychotic and mood disorders. Assuming causality, interventions to reduce air pollution exposure could improve mental health prognoses and reduce healthcare costs.
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- 2022
9. The mediating effect of activity restriction on the relationship between perceived physical symptoms and depression in cancer survivors
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Shin ichi Suzuki, Kotone Hata, Yuko Ogawa, and Haruka Ono
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Paper ,Male ,Cancer Fatigue ,Pain ,Experimental and Cognitive Psychology ,Hospital Anxiety and Depression Scale ,Perceived pain ,03 medical and health sciences ,0302 clinical medicine ,Cancer Survivors ,Japan ,Survivorship curve ,Activities of Daily Living ,medicine ,cancer ,Humans ,030212 general & internal medicine ,mediation analysis ,Depression (differential diagnoses) ,Depression ,business.industry ,Cancer ,Direct path ,Middle Aged ,medicine.disease ,activity restriction ,Psychiatry and Mental health ,Oncology ,030220 oncology & carcinogenesis ,Papers ,fatigue ,Female ,Pain catastrophizing ,business ,Clinical psychology - Abstract
Purpose Several studies have explored factors causing depression in cancer survivors, including perceived physical symptoms. Another critical factor in the depression symptomatology of cancer survivors is activity restriction (AR). We investigated how AR mediate the effects of perceived pain and fatigue on depression in cancer survivors. Methods Cancer survivors (n = 61; mean age 56.16 years) that were recruited through cancer support groups in Japan participated in this study. Participants completed a battery of questionnaires comprising demographic and clinical information, the Pain Catastrophizing Scale, the Cancer Fatigue Scale, the Activity Restriction Scale for Cancer Patients, and the Hospital Anxiety and Depression Scale. Results Mediation analysis indicated that AR partially mediates the effect of pain on depression. Direct paths from pain to AR, AR to depression, and pain to depression were significant (P
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- 2020
10. Long‐term efficacy of meaning‐centered group psychotherapy for cancer survivors: 2‐Year follow‐up results of a randomized controlled trial
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Karen Holtmaat, Birgit I. Lissenberg-Witte, William Breitbart, Pim Cuijpers, Nadia van der Spek, Irma M. Verdonck-de Leeuw, Clinical Psychology, APH - Mental Health, World Health Organization (WHO) Collaborating Center, APH - Global Health, Clinical, Neuro- & Developmental Psychology, Otolaryngology / Head & Neck Surgery, APH - Personalized Medicine, and CCA - Cancer Treatment and quality of life
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Paper ,group psychotherapy ,Adult ,Male ,psychological adaptation ,medicine.medical_treatment ,Experimental and Cognitive Psychology ,law.invention ,Group psychotherapy ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,SDG 3 - Good Health and Well-being ,follow‐up studies ,Cancer Survivors ,law ,Psychological adaptation ,Intervention (counseling) ,Outcome Assessment, Health Care ,medicine ,cancer survivors ,cancer ,Humans ,030212 general & internal medicine ,outcome assessment ,psychological stress ,Depression (differential diagnoses) ,Netherlands ,Intention-to-treat analysis ,Posttraumatic growth ,business.industry ,Depression ,Middle Aged ,follow-up studies ,Personal development ,Psychiatry and Mental health ,030220 oncology & carcinogenesis ,depression ,Papers ,oncology ,intention‐to‐treat analysis ,Psychotherapy, Group ,Quality of Life ,intention-to-treat analysis ,Female ,business ,Clinical psychology ,Follow-Up Studies - Abstract
Objective: Meaning-centered group psychotherapy for cancer survivors (MCGP-CS) is an effective intervention to improve personal meaning, psychological well-being, and depressive symptoms until 6 months after the intervention. In this study, the long-term effects of MCGP-CS (i.e., at 1- and 2-year follow-up) on meaning, psychological well-being and posttraumatic growth were assessed, in comparison to supportive group psychotherapy (SGP) and care as usual (CAU). Methods: Cancer survivors (n = 170) were randomized into MCGP-CS, SGP, or CAU. Assessments were scheduled at baseline, 1 week, 3 months, 6 months, 1 year, and 2 years postintervention. Outcome measures were the Personal Meaning Profile, Ryff's Scales of Psychological Well-Being (SPWB), the Posttraumatic Growth Inventory, and their subscales. Linear mixed models (LMM) were used and results were both reported on an intention-to-treat (ITT) basis, as well as for intervention completers only. Results: LMM and post hoc analyses with Bonferroni correction revealed that MCGP-CS participants reported more improvement on positive relations (subscale of SPWB) than CAU participants of 2-year postintervention (ITT analysis, Cohen's d =.82). Completers also reported more personal growth (subscale of SPWB) after MCGP-CS than after SGP 1-year postintervention (Cohen's d =.94). No long-term effects were found on the other outcome measures. Conclusions: In the 2 years after MCGP-CS, the short-term significant effects on personal meaning and most positive effects related to psychological well-being faded. However, MCGP-CS had a long-term positive effect on positive relations with others and on survivors' sense of personal growth. Trial registration: Netherlands Trial Register: NTR3571.
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- 2020
11. Screening for post‐traumatic stress disorders in 1017 cancer patients and correlation with anxiety, depression, and distress
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Matthias Preusser, Mathias Jachs, Katharina Krammer, Hanna Puhr, Alexander Gaiger, Stefan Zehentgruber, Simone Lubowitzki, Ulrich Jaeger, Jasmin Riedel, Benjamin Vyssoki, Lukas Baumann, Gerald W. Prager, Matthias Unseld, and Eva Katharina Masel
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Paper ,Adult ,Male ,medicine.medical_specialty ,Anxiety depression ,post‐traumatic stress disorders ,Experimental and Cognitive Psychology ,Comorbidity ,Anxiety ,Stress Disorders, Post-Traumatic ,Correlation ,03 medical and health sciences ,Mental distress ,0302 clinical medicine ,Neoplasms ,Internal medicine ,Prevalence ,medicine ,cancer ,Humans ,030212 general & internal medicine ,Depression (differential diagnoses) ,Aged ,clinical oncology ,Hematology ,Depression ,business.industry ,distress ,Cancer ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Distress ,Oncology ,Austria ,030220 oncology & carcinogenesis ,Papers ,Female ,medicine.symptom ,business - Abstract
Objective Post‐traumatic stress disorder (PTSD) is a severe psychiatric disorder, which might develop after a traumatic event, like cancer diagnosis, and threatens the patient's psychological and/or physiological integrity. Anxiety, depression, and mental distress are known to be common in cancer patients; however, the frequency of PTSD was not investigated thoroughly in this patient group so far. Here, we aim to screen cancer patients for PTSD symptoms and determine a possible correlation with anxiety, depression, and distress. Methods The study was performed at the Divisions of Hematology and Oncology of the Medical University of Vienna from 2010 to 2018. Following written consent, patients were asked to fill out the validated self‐assessment questionnaire for PTSS‐10 and HADS. The study was approved by the institutional ethics committee of the Medical University of Vienna (EC Nr: 2255/2016). Results A total of 1017 adult cancer patients (513 male, 504 female) were included in a cross‐sectional single‐center study. Mean age was 57.6 years (SD 14.4 years); 31.7%, 14.6%, 13.2%, and 27.4% of patients outscored the predefined thresholds for self‐assessed cases of PTSD, anxiety, depression, and distress, respectively. Compared with men, women showed a higher prevalence of symptoms for PTSD (38.9% vs 24.5%; P
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- 2019
12. Using smart‐messaging to enhance mindfulness‐based cognitive therapy for cancer patients: A mixed methods proof of concept evaluation
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Nima Moghaddam, Tim Sweeney, Chloe Wells, Sanchia Biswas, Simon P. Clarke, Sam Malins, Jo Levene, and Iwona Skorodzien
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Paper ,Adult ,Male ,medicine.medical_specialty ,Mindfulness ,mindfulness ,telehealth ,medicine.medical_treatment ,education ,Experimental and Cognitive Psychology ,Telehealth ,Anxiety ,dropout ,Proof of Concept Study ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Intervention (counseling) ,Neoplasms ,Medicine ,cancer ,Humans ,030212 general & internal medicine ,Depression (differential diagnoses) ,Mindfulness-based cognitive therapy ,Cognitive Behavioral Therapy ,business.industry ,Depression ,technology, industry, and agriculture ,humanities ,Telemedicine ,Psychiatry and Mental health ,Treatment Outcome ,030220 oncology & carcinogenesis ,Papers ,cognitive therapy ,oncology ,Cognitive therapy ,Physical therapy ,Quality of Life ,Female ,medicine.symptom ,business - Abstract
Objective \ud Depression and anxiety lead to reduced treatment adherence, poorer quality of life, and increased care costs amongst cancer patients. Mindfulness‐based cognitive therapy (MBCT) is an effective treatment, but dropout reduces potential benefits. Smart‐message reminders can prevent dropout and improve effectiveness. However, smart‐messaging is untested for MBCT in cancer. This study evaluates smart‐messaging to reduce dropout and improve effectiveness in MBCT for cancer patients with depression or anxiety.MethodsFifty‐one cancer patients attending MBCT in a psycho‐oncology service were offered a smart‐messaging intervention, which reminded them of prescribed between‐session activities. Thirty patients accepted smart‐messaging and 21 did not. Assessments of depression and anxiety were taken at baseline, session‐by‐session, and one‐month follow‐up. Logistic regression and multilevel modelling compared the groups on treatment completion and clinical effectiveness. Fifteen post‐treatment patient interviews explored smart‐messaging use.ResultsThe odds of programme completion were eight times greater for patients using smart‐messaging compared with non‐users, controlling for age, gender, baseline depression, and baseline anxiety (OR = 7.79, 95% CI 1.75 to 34.58, p = .007). Smart‐messaging users also reported greater improvement in depression over the programme (B = ‐2.33, SEB = .78, p = .004) when controlling for baseline severity, change over time, age, and number of sessions attended. There was no difference between groups in anxiety improvement (B = ‐1.46, SEB = .86, p = .097). In interviews, smart‐messaging was described as a motivating reminder and source of personal connection. ConclusionsSmart‐messaging may be an easily integrated telehealth intervention to improve MBCT for cancer patients.
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- 2019
13. Mood, anxiety, and perceived quality of life in adults with epilepsy and intellectual disability
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Jans S. van Ool, Francesca M. Snoeijen-Schouwenaars, In Y. Tan, Helenius J. Schelhaas, Albert P. Aldenkamp, Jos G.M. Hendriksen, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Klinische Neurowetenschappen, Center for Care & Cure Technology Eindhoven, and Signal Processing Systems
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Male ,validity ,Quality of Life/psychology ,developmental disability ,Anxiety ,SDG 3 – Goede gezondheid en welzijn ,Intellectual Disability/complications ,Epilepsy ,0302 clinical medicine ,Surveys and Questionnaires ,Intellectual disability ,Prevalence ,anxiety disorder ,030212 general & internal medicine ,Depression (differential diagnoses) ,seizures ,Seizure types ,Anticonvulsants/therapeutic use ,General Medicine ,Middle Aged ,Neurology ,depression ,Anticonvulsants ,Female ,medicine.symptom ,mental health ,Anxiety/epidemiology ,Anxiety disorder ,Clinical psychology ,Adult ,Depression/epidemiology ,Young Adult ,03 medical and health sciences ,Quality of life (healthcare) ,SDG 3 - Good Health and Well-being ,Intellectual Disability ,medicine ,Humans ,Epilepsy/complications ,Aged ,people ,reliability ,business.industry ,paper ,medicine.disease ,Affect ,Mood ,Quality of Life ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Objective: Depression and anxiety symptoms are common among patients with epilepsy, but are relatively under-researched in patients with both epilepsy and intellectual disability (ID). The aim was to investigate whether epilepsy and ID characteristics are associated with mood, anxiety, and quality of life. Materials and Methods: Adult patients with epilepsy and ID who rely on tertiary epilepsy care were included (N = 189). Mood, anxiety, and quality of life were assessed by standardized questionnaires. Epilepsy and ID characteristics were retrieved from patient charts or determined by psychometric instruments. Results: Elevated levels of depressive and anxiety symptoms were present in 21.7% and 12.7%, respectively. Anxiety was significantly associated with a focal epilepsy type and ID domain discrepancy (substantial difference between two domains of adaptive behavior), but was negatively related to seizure frequency and drug load of mood-stabilizing antiepileptic drugs. Depressive symptoms were not significantly related to epilepsy characteristics, but a severe ID and ID domain discrepancy was associated with more depressive symptoms. Quality of life was significantly worse in those with multiple seizure types and ID domain discrepancy. Conclusion: Whereas anxiety and quality of life are associated with individual epilepsy characteristics, this could not be confirmed for depressive symptoms in patients with epilepsy and ID, despite its high prevalence.
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- 2019
14. Reasons for low uptake of a psychological intervention offered to cancer survivors with elevated depressive symptoms
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Robert J. van Ginkel, Robbert Sanderman, Thera P. Links, Loek J. van der Donk, Joke Fleer, Veronique E.M. Mul, Jan L. N. Roodenburg, Peter C. Baas, Maya J. Schroevers, Henriette J. G. Arts, Christiaan Hoff, K. Annika Tovote, Johanna Kluin-Nelemans, Psychology, Health & Technology, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Targeted Gynaecologic Oncology (TARGON), Clinical Psychology and Experimental Psychopathology, and Lifelong Learning, Education & Assessment Research Network (LEARN)
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Paper ,medicine.medical_specialty ,CONSORT ,Psychological intervention ,UT-Hybrid-D ,screening guidelines ,Experimental and Cognitive Psychology ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Standard care ,Randomized controlled trial ,law ,Medicine ,cancer ,cancer survivors ,030212 general & internal medicine ,Depressive symptoms ,Depression (differential diagnoses) ,business.industry ,screening ,Cancer ,medicine.disease ,humanities ,Psychiatry and Mental health ,recruitment ,030220 oncology & carcinogenesis ,Family medicine ,Papers ,depression ,oncology ,randomized controlled trial ,Observational study ,business ,Limited resources ,consecutive screening - Abstract
Objective In line with screening guidelines, cancer survivors were consecutively screened on depressive symptoms (as part of standard care), with those reporting elevated levels of symptoms offered psychological care as part of a trial. Because of the low uptake, no conclusions could be drawn about the interventions' efficacy. Given the trial set‐up (following screening guidelines and strict methodological quality criteria), we believe that this observational study reporting the flow of participation, reasons for and characteristics associated with nonparticipation, adds to the debate about the feasibility and efficiency of screening guidelines. Methods Two thousand six hundred eight medium‐ to long‐term cancer survivors were consecutively screened on depressive symptoms using the Patient Health Questionnaire‐9 (PHQ‐9). Those with moderate depressive symptoms (PHQ‐9 ≥ 10) were contacted and informed about the trial. Patient flow and reasons for nonparticipation were carefully monitored. Results One thousand thirty seven survivors (74.3%) returned the questionnaire, with 147 (7.6%) reporting moderate depressive symptoms. Of this group, 49 survivors (33.3%) were ineligible, including 26 survivors (17.7%) already receiving treatment and another 44 survivors (30.0%) reporting no need for treatment. Only 25 survivors (1.0%) participated in the trial. Conclusion Of the approached survivors for screening, only 1% was eligible and interested in receiving psychological care as part of our trial. Four reasons for nonparticipation were: nonresponse to screening, low levels of depressive symptoms, no need, or already receiving care. Our findings question whether to spend the limited resources in psycho‐oncological care on following screening guidelines and the efficiency of using consecutive screening for trial recruitment in cancer survivors.
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- 2019
15. Reported Affect Changes as a Function of Response Delay: Findings From a Pooled Dataset of Nine Experience Sampling Studies
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Inez Myin-Germeys, Hugo Vachon, Gudrun Eisele, Wolfgang Viechtbauer, Psychiatrie & Neuropsychologie, and RS: MHeNs - R2 - Mental Health
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medicine.medical_specialty ,Experience sampling method ,lcsh:BF1-990 ,response delay ,STRESS REACTIVITY ,Audiology ,Affect (psychology) ,response latency ,03 medical and health sciences ,0302 clinical medicine ,PSYCHOSIS ,medicine ,Psychology ,030212 general & internal medicine ,RAFAELI ,General Psychology ,Depression (differential diagnoses) ,Original Research ,ambulatory assessment ,CORTISOL ,ecological momentary assessment ,Response delay ,DEPRESSION ,SHROUT ,030227 psychiatry ,experience sampling ,INDIVIDUALS ,lcsh:Psychology ,DAILY-LIFE ,PAPER - Abstract
Delayed responses are a common phenomenon in experience sampling studies. Yet no consensus exists on whether they should be excluded from the analysis or what the threshold for exclusion should be. Delayed responses could introduce bias, but previous investigations of systematic differences between delayed and timely responses have offered unclear results. To investigate differences as a function of delay, we conducted secondary analyses of nine paper and pencil based experience sampling studies including 1,528 individuals with different clinical statuses. In all participants, there were significant decreases in positive and increases in negative affect as a function of delay. In addition, delayed answers of participants without depression showed higher within-person variability and an initial strengthening in the relationships between contextual stress and affect. Participants with depression mostly showed the opposite pattern. Delayed responses seem qualitatively different from timely responses. Further research is needed to understand the mechanisms underlying these differences. ispartof: Frontiers In Psychology vol:12 ispartof: location:Switzerland status: Published online
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- 2021
16. Mental health and well-being during the COVID-19 pandemic: longitudinal analyses of adults in the UK COVID-19 Mental HealthWellbeing study
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Ronan E. O'Carroll, Eamonn Ferguson, Seonaid Cleare, Claire L. Niedzwiedz, Heather McClelland, Rory C. O'Connor, Ambrose J. Melson, Daryl B. O'Connor, Kathryn A. Robb, Elizabeth Scowcroft, Karen Wetherall, Billy Watson, Steve Platt, and Tiago C. Zortea
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Paper ,medicine.medical_specialty ,Adolescent ,Population ,general population ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,medicine ,Humans ,030212 general & internal medicine ,Young adult ,Psychiatry ,education ,Suicidal ideation ,Pandemics ,Depression (differential diagnoses) ,education.field_of_study ,business.industry ,SARS-CoV-2 ,COVID-19 ,Loneliness ,Mental health ,United Kingdom ,suicidal ideation ,Psychiatry and Mental health ,Mental Health ,Well-being ,Communicable Disease Control ,depression ,Anxiety ,Female ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
BackgroundThe effects of coronavirus disease 2019 (COVID-19) on the population's mental health and well-being are likely to be profound and long lasting.AimsTo investigate the trajectory of mental health and well-being during the first 6 weeks of lockdown in adults in the UK.MethodA quota survey design and a sampling frame that permitted recruitment of a national sample was employed. Findings for waves 1 (31 March to 9 April 2020), 2 (10 April to 27 April 2020) and 3 (28 April to 11 May 2020) are reported here. A range of mental health factors was assessed: pre-existing mental health problems, suicide attempts and self-harm, suicidal ideation, depression, anxiety, defeat, entrapment, mental well-being and loneliness.ResultsA total of 3077 adults in the UK completed the survey at wave 1. Suicidal ideation increased over time. Symptoms of anxiety, and levels of defeat and entrapment decreased across waves whereas levels of depressive symptoms did not change significantly. Positive well-being also increased. Levels of loneliness did not change significantly over waves. Subgroup analyses showed that women, young people (18–29 years), those from more socially disadvantaged backgrounds and those with pre-existing mental health problems have worse mental health outcomes during the pandemic across most factors.ConclusionsThe mental health and well-being of the UK adult population appears to have been affected in the initial phase of the COVID-19 pandemic. The increasing rates of suicidal thoughts across waves, especially among young adults, are concerning.
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- 2020
17. Effectiveness of nurse-led group CBT for hot flushes and night sweats in women with breast cancer: Results of the MENOS4 randomised controlled trial
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Deborah Fenlon, Jo Fields, Gareth Griffiths, Tom Maishman, James Raftery, Jacqueline Nuttall, Carl May, Myra S. Hunter, Mary Ellis, Laura Day, and Lesley Turner
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specialist nurse ,Nurses ,Anxiety ,law.invention ,Nurse led ,0302 clinical medicine ,Randomized controlled trial ,Quality of life ,law ,Surveys and Questionnaires ,Clinical endpoint ,030212 general & internal medicine ,Sweat ,Depression (differential diagnoses) ,Depression ,Middle Aged ,Psychiatry and Mental health ,Treatment Outcome ,030220 oncology & carcinogenesis ,Papers ,oncology ,Psychotherapy, Group ,Female ,hot flushes ,medicine.symptom ,Paper ,Adult ,medicine.medical_specialty ,night sweats ,CBT ,Experimental and Cognitive Psychology ,Breast Neoplasms ,Sweating ,03 medical and health sciences ,Breast cancer ,breast cancer ,Rating scale ,medicine ,cancer ,Humans ,Aged ,Cognitive Behavioral Therapy ,business.industry ,medicine.disease ,Hot Flashes ,Physical therapy ,Quality of Life ,business ,Sleep - Abstract
OBJECTIVE: Troublesome hot flushes and night sweats (HFNS) are experienced by many women after treatment for breast cancer, impacting significantly on sleep and quality of life. Cognitive behavioural therapy (CBT) is known to be effective for the alleviation of HFNS. However, it is not known if it can effectively be delivered by specialist nurses. We investigated whether group CBT, delivered by breast care nurses (BCNs), can reduce the impact of HFNS.METHODS: We recruited women with primary breast cancer following primary treatment with seven or more HFNS/week (including 4/10 or above on the HFNS problem rating scale), from six UK hospitals to an open, randomised, phase 3 effectiveness trial. Participants were randomised to Group CBT or usual care (UC). The primary endpoint was HFNS problem rating at 26 weeks after randomisation. Secondary outcomes included sleep, depression, anxiety and quality of life.RESULTS: Between 2017 and 2018, 130 participants were recruited (CBT:63, control:67). We found a 46% (6.9-3.7) reduction in the mean HFNS problem rating score from randomisation to 26 weeks in the CBT arm and a 15% (6.5-5.5) reduction in the UC arm (adjusted mean difference -1.96, CI -3.68 to -0.23, P = .039). Secondary outcomes, including frequency of HFNS, sleep, anxiety and depression all improved significantly.CONCLUSION: Our results suggest that specialist nurses can be trained to deliver CBT effectively to alleviate troublesome menopausal hot flushes in women following breast cancer in the NHS setting.
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- 2020
18. A self-help intervention for reducing time to diagnosis in Indonesian women with breast cancer symptoms
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Jan Passchier, Hari Setyowibowo, Sawitri S. Sadarjoen, Drajat R. Suardi, Aulia Iskandarsyah, Joke A. M. Hunfeld, Edith van't Hof, Marit Sijbrandij, Dharmayanti F. Badudu, Whisnu Yudiana, Clinical Psychology, World Health Organization (WHO) Collaborating Center, APH - Mental Health, and Psychiatry
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Time Factors ,diagnosis ,Health Status ,medicine.medical_treatment ,Health Behavior ,cluster randomized controlled trial ,Anxiety ,Hospital Anxiety and Depression Scale ,0302 clinical medicine ,Quality of life ,030212 general & internal medicine ,adherence ,Referral and Consultation ,Depression (differential diagnoses) ,Depression ,Middle Aged ,Psychiatry and Mental health ,030220 oncology & carcinogenesis ,Papers ,oncology ,Female ,medicine.symptom ,Paper ,Adult ,medicine.medical_specialty ,Breast Neoplasms ,Experimental and Cognitive Psychology ,self-help psychoeducation ,Disease cluster ,03 medical and health sciences ,Breast cancer ,self‐help psychoeducation ,SDG 3 - Good Health and Well-being ,Internal medicine ,Intervention (counseling) ,medicine ,Psychoeducation ,health education ,Humans ,cancer ,breast ,business.industry ,Self-Management ,medicine.disease ,Indonesia ,Quality of Life ,Patient Compliance ,business - Abstract
Objective: We investigated the effectiveness of a self-help intervention named PERANTARA, which aims to improve adherence to diagnostic procedures among women with breast cancer (BC) symptoms to reduce the time to a definitive diagnosis. Methods: With a cluster randomized crossover design across four hospitals, PERANTARA and treatment as usual (TAU) or TAU only was provided at successive periods in a randomly determined order. The main outcome was the time between the first medical consultation and the definitive diagnosis. Secondary outcomes were BC knowledge, measured by the Breast Cancer Knowledge Test (BCKT); symptoms of anxiety and depression, measured by the Hospital Anxiety and Depression Scale (HADS); quality of life, measured by the World Health Organization Quality of Life-BREF (WHOQOL-BREF); and health status, measured by the EQ-5D-5L. A linear mixed model analysis was conducted to analyse the outcomes. Results: We recruited 132 women with BC symptoms from four hospitals; 67 participants were in the intervention group, and 65 participants were in the control group. PERANTARA reduced the time to definitive diagnosis by 13.3 days (M [SD]: 25.90 [23.20] in the intervention group vs 39.29 [35.10] in the control group; mean difference = −13.26, 95% CI = −24.51 to −2.00, P =.02). No significant difference was found between the groups in BC knowledge, symptoms of anxiety, depression, quality of life, or health status. Conclusions: PERANTARA reduced the time to definitive diagnosis among Indonesian women with BC symptoms. Psychoeducation may be an important addition to regular BC care to prevent undue delays in diagnostic procedures.
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- 2020
19. Internet-delivered Mindfulness-Based Cognitive Therapy for anxiety and depression in cancer survivors:A randomized controlled trial
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Maja O'Connor, Mimi Mehlsen, Viktor Kaldo, Inger Højris, Michael Borre, Eva Rames Nissen, and Robert Zachariae
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Adult ,Male ,Paper ,medicine.medical_specialty ,Mindfulness ,mindfulness ,medicine.medical_treatment ,Experimental and Cognitive Psychology ,Anxiety ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,breast cancer ,depressive symptoms ,Cancer Survivors ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Humans ,cancer ,cancer survivors ,030212 general & internal medicine ,Mindfulness-based cognitive therapy ,Cognitive Behavioral Therapy ,Depression ,business.industry ,Cancer ,Middle Aged ,medicine.disease ,anxiety ,prostate cancer ,humanities ,Psychiatry and Mental health ,Distress ,Oncology ,030220 oncology & carcinogenesis ,Papers ,cognitive therapy ,oncology ,Cognitive therapy ,Female ,internet ,medicine.symptom ,business ,Internet-Based Intervention - Abstract
Objective Internet‐delivered interventions may alleviate distress in cancer survivors with limited access to psychological face‐to‐face treatment. In collaboration with a group of cancer survivors, we developed and tested the efficacy of a therapist‐assisted internet‐delivered mindfulness‐based cognitive therapy (iMBCT) program for anxiety and depression in cancer survivors. Methods A total of 1282 cancer survivors were screened for anxiety and depression during their routine oncology follow‐up; eligible breast (n = 137) and prostate cancer (n = 13) survivors were randomized to iMBCT or care‐as‐usual (CAU) wait‐list. Primary outcomes of anxiety and depression were assessed at baseline, 5 weeks, 10 weeks (post intervention), and 6 months. Results Significant effects were found for both anxiety (Cohen's d = 0.45; P = .017) and depressive symptoms (d = 0.42; P = .024) post intervention. The effects were maintained at follow‐up for anxiety (d = 0.40; P = .029), but not for depressive symptoms (d = 0.28; P = .131). Conclusions Our preliminary findings suggest iMBCT to be a helpful intervention for cancer survivors suffering from symptoms of anxiety. Further studies on the efficacy for symptoms of depression are needed.
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- 2020
20. Cocreated internet-based stepped care for individuals with cancer and concurrent symptoms of anxiety and depression : Results from the U-CARE AdultCan randomized controlled trial
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Helena Igelström, Birgitta Johansson, Louise von Essen, Anna Hauffman, Susanne Mattsson, Marina Forslund, Peter Nygren, Sven Alfonsson, Anna Bill-Axelson, and Leif Bergkvist
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Male ,medicine.medical_treatment ,Anxiety ,Hospital Anxiety and Depression Scale ,law.invention ,Stress Disorders, Post-Traumatic ,0302 clinical medicine ,Randomized controlled trial ,Quality of life ,law ,Neoplasms ,Medicine ,030212 general & internal medicine ,technology-based interventions ,Depression (differential diagnoses) ,Depression ,Middle Aged ,anxiety ,Telemedicine ,Cognitive behavioral therapy ,Psychiatry and Mental health ,Treatment Outcome ,030220 oncology & carcinogenesis ,Papers ,depression ,oncology ,Female ,medicine.symptom ,Paper ,Adult ,medicine.medical_specialty ,Randomization ,Experimental and Cognitive Psychology ,Nursing ,psychosocial intervention ,technology‐based interventions ,03 medical and health sciences ,Psychoeducation ,Humans ,cancer ,Internet ,Cancer och onkologi ,Cognitive Behavioral Therapy ,business.industry ,Omvårdnad ,psycho‐oncology ,Cancer and Oncology ,randomized controlled trial ,Physical therapy ,Quality of Life ,psycho-oncology ,eHealth ,Self Report ,internet ,business - Abstract
Objective The aim was to evaluate the effects of cocreated internet-based stepped care (iCAN-DO) on anxiety, depression, posttraumatic stress, and health-related quality of life (HRQoL) in individuals with cancer and self-reported anxiety and/or depression symptoms, compared with standard care. Methods Clinically recruited individuals with breast, colorectal, or prostate cancer underwent online screening with the Hospital Anxiety and Depression Scale (HADS). Those with anxiety and/or depression symptoms (>7 on any of the HADS subscales) were randomized to iCAN-DO or standard care. iCAN-DO comprised psychoeducation and self-care strategies (step 1) and internet-based cognitive behavioral therapy (iCBT, step 2). Data were collected before randomization and at 1, 4, 7, and 10 months and analyzed with intention-to-treat regression analysis and randomization tests. Results Online screening identified 245 (27%) of 909 individuals who reported anxiety and/or depression symptoms. They were randomized to iCAN-DO (n = 124) or standard care (n = 121). Of them 49% completed the 10-month assessment, and in the iCAN-DO group 85% accessed step 1 and 13% underwent iCBT. iCAN-DO decreased the levels of symptoms of depression (−0.54, 95% confidence interval: −1.08 to −0.01, P < .05) and the proportion of individuals with symptoms of depression (P < .01) at 10 months, compared with standard care, according to HADS. There were no significant effects on anxiety, posttraumatic stress, or HRQoL. Conclusion Internet-based stepped care improves symptoms of depression in individuals with cancer. Further studies are needed to gain knowledge on how to optimize and implement internet-based support in oncology care.
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- 2020
21. Course and predictors of supportive care needs among Mexican breast cancer patients
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Joke Fleer, Adelita V. Ranchor, Juan José Sánchez Sosa, Maya J. Schroevers, Patricia Alanís López, Adriana Pérez-Fortis, Christine Eulenburg, Health Psychology Research (HPR), Life Course Epidemiology (LCE), and Lifelong Learning, Education & Assessment Research Network (LEARN)
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Paper ,Adult ,medicine.medical_specialty ,Longitudinal study ,Breast Neoplasms ,Experimental and Cognitive Psychology ,HONG-KONG CHINESE ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,breast cancer ,UNMET INFORMATION NEEDS ,needs assessment ,Surveys and Questionnaires ,medicine ,Humans ,Daily living ,Longitudinal Studies ,030212 general & internal medicine ,Mexico ,Aged ,Estimation ,Response rate (survey) ,Health Services Needs and Demand ,Depression ,business.industry ,Disease trajectory ,Latinas ,WOMEN ,Middle Aged ,medicine.disease ,PREVALENCE ,supportive care ,Psychiatry and Mental health ,Patient Satisfaction ,030220 oncology & carcinogenesis ,Family medicine ,Papers ,Needs assessment ,oncology ,Women's Health ,Female ,Observational study ,HEALTH ,business - Abstract
Objective: This study examined the course and predictors of supportive care needs among Mexican breast cancer patients for different cancer treatment trajectories.Methods: Data from 172 (66.4% response rate) patients were considered in this observational longitudinal study. Participants were measured after diagnosis, neoadjuvant treatment, surgery, adjuvant treatment, and the first post-treatment follow-up visit. Psychological, Health System and Information, Physical and Daily Living, Patient Care and Support, Sexual, and Additional care needs were measured with the Supportive Care Needs Survey (SCNS-SF34). Linear mixed models with maximum-likelihood estimation were computed.Results: The course of supportive care needs was similar across the different cancer treatment trajectories. Supportive care needs declined significantly from diagnosis to the first post-treatment follow-up visit. Health System and Information care needs were the highest needs over time. Depressive symptoms and time since diagnosis were the most consistent predictors of changes in course of supportive care needs of these patients.Conclusions: Health system and information care needs of Mexican breast cancer patients need to be addressed with priority because these needs are the least met. Furthermore, patients with high depressive symptoms at the start of the disease trajectory have greater needs for supportive care throughout the disease trajectory.
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- 2018
22. Long-term clinical and cost-effectiveness of collaborative care (versus usual care) for people with mental–physical multimorbidity: cluster-randomised trial
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Carolyn Chew-Graham, Mark Hann, Clare Baguely, Linda Gask, Chris Gibbons, Waquas Waheed, Peter A. Coventry, Karina Lovell, Peter Bower, Elizabeth Camacho, Nicola Small, Chris Dickens, and Linda Davies
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Paper ,Male ,medicine.medical_specialty ,Cost effectiveness ,Cost-Benefit Analysis ,MEDLINE ,Collaborative Care ,Coronary Disease ,RC435 ,law.invention ,Diabetes Complications ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,Randomized controlled trial ,law ,Surveys and Questionnaires ,medicine ,Cluster Analysis ,Humans ,030212 general & internal medicine ,Depression (differential diagnoses) ,Aged ,Patient Care Team ,Primary Health Care ,business.industry ,Delivery of Health Care, Integrated ,Depression ,030503 health policy & services ,Multimorbidity ,Middle Aged ,Quality-adjusted life year ,Psychiatry and Mental health ,Family medicine ,Economic evaluation ,Linear Models ,Quality of Life ,Female ,Quality-Adjusted Life Years ,0305 other medical science ,business - Abstract
Background Collaborative care can effectively support the treatment of depression in people with multiple long-term physical conditions or mental-physical multimorbidity, but long term benefits and costs are unknown. AimsTo explore the long-term effectiveness and cost-effectiveness of collaborative care in people with mental-physical multimorbidity.MethodA cluster randomised trial of 36 general practices in England compared collaborative care with usual care (standard management by primary care staff) for people with depression and comorbid diabetes and/or coronary heart disease. Collaborative care included up to eight sessions of low-intensity psychological therapy with lifestyle/disease management advice (integrated physical and mental health care). Depression symptoms were measured using the symptom checklist-13 depression scale (SCL-D13) 24 months after baseline. The EQ-5D-5L was used to capture health status and calculate quality adjusted life years (QALYs) for the economic evaluation from the perspective of the National Health Service (NHS) in England.Results191 participants were allocated to collaborative care and 196 to usual care. At 24-months the mean SCL-D13 score was 0.27 (95% CI -0.48, -0.06) lower in participants in the collaborative care arm. Collaborative care was also associated with a QALY gain of 0.14 (95% CI 0.06, 0.21); the cost per additional QALY gained was £13,069. There is a 75% probability that collaborative care is cost-effective at a threshold of £20,000/QALY.ConclusionsIntegrated collaborative care effectively reduces depression over the long term and can improve physical functioning. Collaborative care is potentially cost-effective over the long-term at internationally accepted willingness to pay thresholds.
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- 2018
23. Diagnosed depression and sociodemographic factors as predictors of mortality in patients with dementia
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Nomi Werbeloff, Joseph Hayes, Gemma Lewis, David Osborn, and Robert Howard
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Paper ,Male ,Pediatrics ,medicine.medical_specialty ,Databases, Factual ,common ,MEDLINE ,White People ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Risk Factors ,medicine ,Dementia ,Humans ,030212 general & internal medicine ,Depression (differential diagnoses) ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,Psychiatric Status Rating Scales ,Depressive Disorder ,Proportional hazards model ,business.industry ,Depression ,common.demographic_type ,Hazard ratio ,Middle Aged ,medicine.disease ,Mental health ,United Kingdom ,3. Good health ,Psychiatry and Mental health ,Female ,business ,030217 neurology & neurosurgery ,Cohort study ,White British - Abstract
BackgroundPotentially modifiable risk factors for developing dementia have been identified. However, risk factors for increased mortality in patients with diagnosed dementia are not well understood. Identifying factors that influence prognosis would help clinicians plan care and address unmet needs.AimsTo investigate diagnosed depression and sociodemographic factors as predictors of mortality in patients with dementia in UK secondary clinical care services.MethodWe conducted a cohort study of patients with a dementia diagnosis in an electronic health records database in a UK National Health Service mental health trust.ResultsIn 3374 patients with 10 856 person-years of follow-up, comorbid depression was not associated with mortality (adjusted hazard ratio 0.94; 95% CI 0.71–1.24). Single patients had higher mortality than those who were married (adjusted hazard ratio 1.25; 95% CI 1.03–1.50). Patients of Asian ethnicity had lower mortality rates than White British patients (adjusted hazard ratio 0.50; 95% CI 0.34–0.73).ConclusionsClinically diagnosed depression does not increase mortality in patients with dementia. Patients who are single are a potential high-mortality risk group. Lower mortality rates in Asian patients with dementia that have been reported in the USA also apply in the UK.Declaration of interestNone.
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- 2018
24. Africa on the Eve of Partition.
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North of the equator It has become a truism of historical writing to conceive of Africa in the course of the nineteenth century as becoming increasingly a part of, and a product of, the expansion of Europe, which, beginning in the fifteenth and sixteenth centuries, had integrated ever larger areas of the world into a single economic system. In attempting an overview of the state of the continent on the eve of partition – roughly over the decade of the 1870s – a large number of questions arise from a consideration of this truism. To what extent was Africa already an adjunct of an economic system dominated by Europe? What was the relationship between Africa and this European system – was it one of an equal or an unequal exchange of commodities? To what extent was Africa dependent economically, if not yet politically? What social and ideological changes were beginning to follow from this dependency? Was Africa a fruit ripe for plucking in the 1870s, was there a certain inevitability about the forthcoming imperialist carve-up, or was partition an extraneous historical occurrence forced upon a continent which had within it other options for coping with the future? There are no answers to these questions that are at the same time simple and sensible. Certainly the answers to all such queries will differ, according to the region of Africa which is under scrutiny. Even within particular regions, the situation of individual states, societies or groups of people, their relations with each other and with the outside world (especially with the European capitalist economies) varied greatly. [ABSTRACT FROM AUTHOR]
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- 1985
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25. Social support as a moderator in the relationship between intrusive thoughts and anxiety among Spanish-speaking Latinas with breast cancer
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Anita L. Stewart, Carmen Ortiz, Anna María Nápoles, Cristian Escalera, and Jasmine Santoyo-Olsson
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Paper ,Adult ,Stress management ,Clinical Sciences ,Oncology and Carcinogenesis ,Hispanic ,Experimental and Cognitive Psychology ,Breast Neoplasms ,and over ,Anxiety ,Thinking ,03 medical and health sciences ,Social support ,0302 clinical medicine ,Breast cancer ,breast cancer ,Latina ,Cancer Survivors ,medicine ,History of depression ,80 and over ,Humans ,Psychology ,030212 general & internal medicine ,Oncology & Carcinogenesis ,Language ,Aged ,Aged, 80 and over ,Depression ,Social Support ,Hispanic or Latino ,Middle Aged ,Protective Factors ,medicine.disease ,Moderation ,Social relation ,3. Good health ,Psychiatry and Mental health ,Oncology ,Latina/Hispanic ,030220 oncology & carcinogenesis ,Papers ,Marital status ,Female ,medicine.symptom ,Hispanic Americans ,Clinical psychology - Abstract
Author(s): Escalera, Cristian; Santoyo-Olsson, Jasmine; Stewart, Anita L; Ortiz, Carmen; Napoles, Anna Maria | Abstract: ObjectiveIntrusive thoughts, defined as unwanted and recurrent thoughts about a stressful experience, are associated with psychological distress in women with breast cancer. This study assessed moderating effects of various social support dimensions on associations between intrusive thoughts and psychological distress among Latina breast cancer survivors.MethodsWe used baseline data from a randomized controlled trial of a stress management intervention delivered to 151 Spanish-speaking Latinas with nonmetastatic breast cancer within 1 year of diagnosis. Intrusive thoughts, four dimensions of social support (emotional/informational, tangible, affectionate, and positive social interaction), and symptoms of anxiety and depression were assessed through in-person interviews. Information on age, time since diagnosis, breast cancer variables, history of depression, and marital status served as covariates. Generalized linear models were used to investigate bivariate and multivariate associations and to explore moderation effects of the four dimensions of social support.ResultsIn bivariate models, intrusive thoughts were associated positively with depression (β = .024, .001) and anxiety (β = .047, P l .001) symptoms. Adjusting for other factors, intrusive thoughts remained associated with depression symptoms (β = .022, .008), regardless of level of social support (for all support dimensions). For anxiety, there were significant interactions of tangible (β = -.013, .034) and affectionate (β = -.022, .005) support with intrusive thoughts. Intrusive thoughts were associated more strongly with anxiety symptoms among women reporting less tangible and affectionate support than those with higher levels of these types of support.ConclusionsTangible and affectionate support have protective effects on anxiety symptoms among Spanish-speaking Latina breast cancer survivors experiencing intrusive thoughts, but not depression symptoms.
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- 2019
26. Anxiety and depression mediate the association between chemotherapy-induced peripheral neuropathy and fatigue: Results from the population-based PROFILES registry
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Pauline A. J. Vissers, Floortje Mols, Dareczka K. Wasowicz, Gerard Vreugdenhil, Dóra Révész, Lonneke V. van de Poll-Franse, Cynthia S Bonhof, Johannes A. Wegdam, and Medical and Clinical Psychology
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Oncology ,Male ,Anxiety ,0302 clinical medicine ,Quality of life ,Cancer Survivors ,QUALITY-OF-LIFE ,030212 general & internal medicine ,Registries ,Depression (differential diagnoses) ,PSYCHOLOGICAL DISTRESS ,chemotherapy‐induced peripheral neuropathy ,Netherlands ,education.field_of_study ,Depression ,Peripheral Nervous System Diseases ,Middle Aged ,humanities ,PREVALENCE ,Psychiatry and Mental health ,Chemotherapy-induced peripheral neuropathy ,030220 oncology & carcinogenesis ,Papers ,oncology ,Female ,medicine.symptom ,Colorectal Neoplasms ,chemotherapy-induced peripheral neuropathy ,Paper ,medicine.medical_specialty ,Mediation (statistics) ,Population ,QUESTIONNAIRE ,Experimental and Cognitive Psychology ,Antineoplastic Agents ,colorectal cancer ,HOSPITAL ANXIETY ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,education ,Aged ,business.industry ,PROFILES ,medicine.disease ,Comorbidity ,Cancer registry ,COLORECTAL-CANCER SURVIVORS ,fatigue ,business ,COMORBIDITY - Abstract
ObjectiveChemotherapy‐induced sensory peripheral neuropathy (CIPN) is common among colorectal cancer (CRC) survivors. The aim of this study was to examine whether CIPN is associated with both psychological distress (ie, anxiety and depression) and fatigue and whether the relationship between CIPN and fatigue can (partly) be explained by psychological distress.MethodsAll CRC survivors diagnosed between 2000 and 2009 as registered by the population‐based Netherlands Cancer Registry (Eindhoven region) were eligible for participation. Chemotherapy‐treated survivors completed questions on CIPN (EORTC QLQ‐CIPN20), psychological distress (HADS), and fatigue (FAS) on average 5.6 years after diagnosis. Simple and multiple mediation analyses were performed to examine anxiety and depression as possible mediators in the association between CIPN and fatigue.ResultsSurvivors with high (ie, upper 30% of scores) CIPN (n = 172) reported more anxiety and depressive symptoms and more fatigue compared with those with low CIPN (n = 299). Furthermore, among survivors with high CIPN, those who were anxious, depressed, or both reported more fatigue compared with those without psychological distress. These differences were clinically relevant. Finally, mediation analyses showed that while CIPN was directly associated with fatigue, the relationship between CIPN and fatigue was also significantly mediated by both anxiety and depression.ConclusionsCRC survivors with high CIPN report more fatigue, especially those who are also anxious and/or depressed. More research is needed on the direction of the relationship between CIPN, psychological distress, and fatigue. For now, the treatment of fatigue should also focus on addressing psychological distress, as treating fatigue alone might not be sufficient.
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- 2019
27. Psycho-Oncology / Recover your smile : effects of a beauty care intervention on depressive symptoms, quality of life, and selfesteem in patients with early breast cancer
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Nadia Harbeck, Anna Richard, Frank H. Wilhelm, and Rachel Wuerstlein
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Paper ,Adult ,medicine.medical_specialty ,Psychological intervention ,Psycho-oncology ,Experimental and Cognitive Psychology ,Breast Neoplasms ,Cosmetics ,psychosocial intervention ,03 medical and health sciences ,Beauty ,0302 clinical medicine ,Breast cancer ,appearance‐related side effects ,breast cancer ,Quality of life ,Intervention (counseling) ,medicine ,Body Image ,Humans ,030212 general & internal medicine ,business.industry ,Depression ,Middle Aged ,medicine.disease ,Self Concept ,patientreported outcomes ,supportive care ,Psychiatry and Mental health ,Distress ,Hair loss ,Treatment Outcome ,psycho‐oncology ,030220 oncology & carcinogenesis ,Papers ,oncology ,Physical therapy ,Quality of Life ,psycho-oncology ,Female ,cancer distress ,business ,patient‐reported outcomes ,Psychosocial ,Follow-Up Studies ,appearancerelated side effects ,beauty care intervention - Abstract
Objective Medical cancer treatment is often accompanied by appearance‐related side effects such as hair loss, skin irritation, and paleness, which can subsequently lead to psychosocial distress. Initial evidence suggests that beauty care interventions may reduce distress and improve quality of life (QoL), body image, and self‐esteem immediately. Methods We investigated the effects of a brief beauty care intervention on self‐reported symptoms of depression, quality of life, body image, and self‐esteem in 39 female primary breast cancer patients with appearance‐related treatment side effects. Patients were randomly assigned either to an immediate intervention group (IG) or to a wait‐list control (WL). The intervention consisted of a single‐session group makeup workshop, a photo shooting, and of receiving professionally edited portrait and upper‐body photos. Results While groups did not differ regarding any measure at the pretreatment baseline assessment, IG patients reported less symptoms of depression, higher QoL, and higher self‐esteem compared with baseline and compared with WL. Follow‐up at 8 weeks indicated moderate stability of these improvements. Conclusions In contrast to previous research, results indicate beneficial short‐term and midterm effects of beauty care on psychological outcomes in patients with early breast cancer. These results emphasize the utility of this type of brief, low‐cost intervention in women undergoing medical cancer treatment in order to improve their well‐being.
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- 2019
28. Comorbidities are associated with poorer quality of life and functioning and worse symptoms in the 5 years following colorectal cancer surgery: results from the ColoREctal Wellbeing (CREW) cohort study
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Jessica Corner, Claire Foster, Jane Winter, Deborah Fenlon, Chloe Grimmett, Peter K. Smith, Amy Din, Mubarak Patel, Lynn Calman, Amanda Cummings, Natalia Vadimovna Permyakova, and Alison Richardson
- Subjects
Male ,Paper ,medicine.medical_specialty ,Activities of daily living ,Time Factors ,longitudinal ,Experimental and Cognitive Psychology ,colorectal cancer ,Comorbidity ,comorbidities ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Cancer Survivors ,Internal medicine ,Surveys and Questionnaires ,Medicine ,Humans ,cancer ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,Depression (differential diagnoses) ,Aged ,business.industry ,Depression ,Social Support ,Middle Aged ,medicine.disease ,health and well‐being ,Psychiatry and Mental health ,Socioeconomic Factors ,quality of life ,030220 oncology & carcinogenesis ,Cohort ,Papers ,oncology ,Anxiety ,Female ,medicine.symptom ,business ,Colorectal Neoplasms ,survivorship ,Cohort study - Abstract
Objective: More people are living with the consequences of cancer and comorbidity. We describe frequencies of comorbidities in a colorectal cancer cohort and associations with health and well‐being outcomes up to 5 years following surgery.Methods: Prospective cohort study of 872 colorectal cancer patients recruited 2010 to 2012 from 29 UK centres, awaiting curative intent surgery. Questionnaires administered at baseline (pre‐surgery), 3, 9, 15, 24 months, and annually up to 5 years. Comorbidities (and whether they limit activities) were self‐reported by participants from 3 months. The EORTC QLQ‐C30 and QLQ‐CR29 assessed global health/quality of life (QoL), symptoms, and functioning. Longitudinal analyses investigated associations between comorbidities and health and well‐being outcomes.Results: At baseline, the mean age of participants was 68 years, with 60% male and 65% colon cancer. Thirty‐two per cent had 1 and 40% had ≥2 comorbidities. The most common comorbidities were high blood pressure (43%), arthritis/rheumatism (32%), and anxiety/depression (18%). Of those with comorbidities, 37% reported at least 1 that limited their daily activities. Reporting any limiting comorbidities was associated with poorer global health/QoL, worse symptoms, and poorer functioning on all domains over 5‐year follow‐up. Controlling for the most common individual comorbidities, depression/anxiety had the greatest deleterious effect on outcomes.Conclusions: Clinical assessment should prioritise patient‐reported comorbidities and whether these comorbidities limit daily activities, as important determinants of recovery of QoL, symptoms, and functioning following colorectal cancer. Targeted interventions and support services, including multiprofessional management and tailored assessment and follow‐up, may aid recovery of health and well‐being in these individuals.
- Published
- 2018
29. Effects of school-based mindfulness training on emotion processing and well-being in adolescents : evidence from event-related potentials
- Author
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Kevanne Louise Sanger, Dusana Dorjee, and Guillaume Thierry
- Subjects
Paper ,Male ,medicine.medical_specialty ,Mindfulness ,Adolescent ,Cognitive Neuroscience ,Emotions ,Happiness ,education ,Audiology ,050105 experimental psychology ,03 medical and health sciences ,0302 clinical medicine ,Event-related potential ,Social cognition ,P3b ,Developmental and Educational Psychology ,medicine ,Humans ,0501 psychology and cognitive sciences ,Habituation ,Oddball paradigm ,Depression ,4. Education ,05 social sciences ,Electroencephalography ,Cognition ,Event-Related Potentials, P300 ,Mental health ,Facial Expression ,Papers ,Quality of Life ,Female ,Psychology ,030217 neurology & neurosurgery - Abstract
In a non‐randomized controlled study, we investigated the efficacy of a school‐based mindfulness curriculum delivered by schoolteachers to older secondary school students (16–18 years). We measured changes in emotion processing indexed by P3b event‐related potential (ERP) modulations in an affective oddball task using static human faces. ERPs were recorded to happy and sad face oddballs presented in a stimulus stream of frequent faces with neutral expression, before and after 8 weeks of mindfulness training. Whilst the mean amplitude of the P3b, an ERP component typically elicited by infrequent oddballs, decreased between testing sessions in the control group, it remained unchanged in the training group. Significant increases in self‐reported well‐being and fewer doctor visits for mental health support were also reported in the training group as compared to controls. The observed habituation to emotional stimuli in controls thus contrasted with maintained sensitivity in mindfulness‐trained students. These results suggest that in‐school mindfulness training for adolescents has scope for increasing awareness of socially relevant emotional stimuli, irrespective of valence, and thus may decrease vulnerability to depression.
- Published
- 2018
30. Depressive symptoms in relation to overall survival in people with head and neck cancer: A longitudinal cohort study
- Author
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Tim Waterboer, Andrea Waylen, Andy R Ness, C. René Leemans, Michael Pawlita, Femke Jansen, Pim Cuijpers, Steven Thomas, Irma M. Verdonck-de Leeuw, Christopher Penfold, CCA - Cancer Treatment and quality of life, Otolaryngology / Head & Neck Surgery, APH - Mental Health, APH - Personalized Medicine, Clinical Psychology, Clinical, Neuro- & Developmental Psychology, and APH - Global Health
- Subjects
Adult ,Male ,Paper ,medicine.medical_specialty ,Health Status ,Experimental and Cognitive Psychology ,Hospital Anxiety and Depression Scale ,survival ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,depressive symptoms ,SDG 3 - Good Health and Well-being ,Cancer Survivors ,Internal medicine ,Medicine ,Humans ,cancer ,030212 general & internal medicine ,Longitudinal Studies ,Prospective Studies ,Depressive symptoms ,Depression (differential diagnoses) ,Aged ,Proportional Hazards Models ,Proportional hazards model ,business.industry ,Depression ,Hazard ratio ,Head and neck cancer ,Cancer ,Social Support ,Middle Aged ,medicine.disease ,mortality ,Confidence interval ,Psychiatry and Mental health ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,depression ,Papers ,oncology ,Female ,head and neck cancer ,business - Abstract
Objective: The objective of the study is to investigate the relation between pretreatment depressive symptoms (DS) and the course of DS during the first year after cancer diagnosis, and overall survival among people with head and neck cancer (HNC). Methods: Data from the Head and Neck 5000 prospective clinical cohort study were used. Depressive symptoms were measured using the Hospital Anxiety and Depression Scale (HADS) pretreatment, at 4 and 12-month follow-up. Also, socio-demographic, clinical, lifestyle, and mortality data were collected. The association between before start of treatment DS (HADS-depression > 7) and course (never DS, recovered from DS, or persistent/recurrent/late DS at 12-month follow-up) and survival was investigated using Cox regression. Unadjusted and adjusted analyses were performed. Results: In total, 384 of the 2144 persons (18%) reported pretreatment DS. Regarding DS course, 63% never had DS, 16% recovered, and 20% had persistent/recurrent/late DS. People with pretreatment DS had a higher risk of earlier death than people without DS (hazard ratio (HR) = 1.65; 95% confidence interval (CI) 1.33-2.05), but this decreased after correcting for socio-demographic, clinical, and lifestyle-related factors (HR = 1.21; 95% CI 0.97-1.52). Regarding the course of DS, people with persistent/recurrent/late DS had a higher risk of earlier death (HR = 2.04; 95% CI 1.36-3.05), while people who recovered had a comparable risk (HR = 1.12; 95% CI 0.66-1.90) as the reference group who never experienced DS. After correcting for socio-demographic and clinical factors, people with persistent/recurrent/late DS still had a higher risk of earlier death (HR = 1.66; 95% CI 1.09-2.53). Conclusions: Pretreatment DS and persistent/recurrent/late DS were associated with worse survival among people with HNC.
- Published
- 2018
31. Psychological distress and quality of life in lung cancer: the role of health‐related stigma, illness appraisals and social constraints
- Author
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Helen Zorbas, Kwun M. Fong, Patricia C. Valery, Suzanne K. Chambers, Dianne L. O'Connell, Peter D. Baade, Joanne F. Aitken, Jeff Dunn, David Ball, Shalini K Vinod, Gail Garvey, Philippa H. Youl, and Stefano Occhipinti
- Subjects
Paper ,Male ,medicine.medical_specialty ,Lung Neoplasms ,Social stigma ,Cross-sectional study ,media_common.quotation_subject ,Social Stigma ,Psychological intervention ,Shame ,Experimental and Cognitive Psychology ,Interpersonal communication ,Anxiety ,Adaptation, Psychological ,medicine ,Humans ,Cancer Control, Survivorship, and Outcomes Research - Population –based Behavioural Factors ,Psychiatry ,Aged ,media_common ,Depression ,Cancer Type - Lung Cancer ,Middle Aged ,Psychiatry and Mental health ,Distress ,Cross-Sectional Studies ,Oncology ,Feeling ,Papers ,Quality of Life ,Female ,Queensland ,New South Wales ,medicine.symptom ,Psychology ,Stress, Psychological ,Clinical psychology - Abstract
Objective Health‐related stigma is associated with negative psychological and quality of life outcomes in lung cancer patients. This study describes the impact of stigma on lung cancer patients' psychological distress and quality of life and explores the role of social constraints and illness appraisal as mediators of effect. Methods A self‐administered cross‐sectional survey examined psychological distress and quality of life in 151 people (59% response rate) diagnosed with lung cancer from Queensland and New South Wales. Health‐related stigma, social constraints and illness appraisals were assessed as predictors of adjustment outcomes. Results Forty‐nine percent of patients reported elevated anxiety; 41% were depressed; and 51% had high global distress. Health‐related stigma was significantly related to global psychological distress and quality of life with greater stigma and shame related to poorer outcomes. These effects were mediated by illness appraisals and social constraints. Conclusions Health‐related stigma appears to contribute to poorer adjustment by constraining interpersonal discussions about cancer and heightening feelings of threat. There is a need for the development and evaluation of interventions to ameliorate the negative effects of health‐related stigma among lung cancer patients. © 2015 The Authors. Psycho‐Oncology Published by John Wiley & Sons Ltd.
- Published
- 2015
32. Prefrontal cortex activation of return-to-work trainees in remission of mental disorders with depressive symptoms compared to that of healthy controls
- Author
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Hiroki Sato, Akiko Obata, Hirokazu Atsumori, Tsukasa Funane, Masashi Kiguchi, and Ritsuko Yamaguchi
- Subjects
Paper ,Adult ,Male ,near-infrared spectroscopy ,Biomedical Engineering ,Neuroimaging ,Profile of mood states ,Return to work ,01 natural sciences ,Spatial memory ,working memory ,Imaging ,010309 optics ,Biomaterials ,mood state ,0103 physical sciences ,medicine ,Humans ,Prefrontal cortex ,Depressive symptoms ,prefrontal cortex ,Spectroscopy, Near-Infrared ,medicine.diagnostic_test ,Depression ,Working memory ,business.industry ,Remission Induction ,return to work ,Middle Aged ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Treatment Outcome ,ROC Curve ,Case-Control Studies ,Regression Analysis ,Biomarker (medicine) ,Female ,Functional magnetic resonance imaging ,business ,Clinical psychology - Abstract
The increase in the number of patients with mental disorders with depressive symptoms has become a significant problem. To prevent people developing those disorders and help with the effective recovery, it is important to quantitatively and objectively monitor an individual’s mental state. Previous studies have shown the relationship between negative or depressive mood state and human prefrontal cortex (PFC) activation during verbal and spatial working memory tasks based on a near-infrared spectroscopy imaging technique. In this study, we aimed to explore a biomarker of the mental state of people in remission of mental disorders with depressive symptoms using this technique. We obtained the PFC activation of return-to-work (RTW) trainees in remission of those disorders, compared that of healthy controls, and obtained subjective questionnaire scores with the Profile of Mood States. We compared the PFC activation with the questionnaire scores by receiver operating characteristic analysis using a logistic-regression model. The results showed that the PFC activation indicates a healthy state compared to that of the RTW trainees evaluated by area-under-curve analysis. This study demonstrates that our PFC measurement technique will be useful as a quantitative and objective assessment of mental state.
- Published
- 2019
33. Measurement agreement of the self-administered questionnaire of the Belgian Health Interview Survey: Paper-and-pencil versus web-based mode
- Author
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Stefaan Demarest, Sabine Drieskens, Johan Van der Heyden, Guido Van Hal, Jean Tafforeau, Lydia Gisle, Geert Molenberghs, Rana Charafeddine, Elise Braekman, and Finaba Berete
- Subjects
Questionnaires ,Male ,020205 medical informatics ,Intraclass correlation ,Social Sciences ,lcsh:Medicine ,Self Administration ,02 engineering and technology ,Health informatics ,Database and Informatics Methods ,0302 clinical medicine ,Belgium ,Surveys and Questionnaires ,Medicine and Health Sciences ,0202 electrical engineering, electronic engineering, information engineering ,Psychology ,EPIDEMIOLOGY ,Public and Occupational Health ,030212 general & internal medicine ,lcsh:Science ,Alcohol Consumption ,Multidisciplinary ,Depression ,Multidisciplinary Sciences ,Alcoholism ,Neurology ,Research Design ,RELIABILITY ,Science & Technology - Other Topics ,Female ,REPORTED OUTCOME MEASURES ,EQUIVALENCE ,Behavioral and Social Aspects of Health ,Engineering sciences. Technology ,Psychosocial ,Research Article ,Clinical psychology ,Adult ,Paper ,Substance-Related Disorders ,Addiction ,Health Informatics ,Research and Analysis Methods ,03 medical and health sciences ,Mental Health and Psychiatry ,Humans ,QUALITY ,INTERNET ,Categorical variable ,Nutrition ,Internet ,Survey Research ,Science & Technology ,Data collection ,Mood Disorders ,business.industry ,lcsh:R ,Biology and Life Sciences ,INSTRUMENTS ,Missing data ,Health Surveys ,Health indicator ,Diet ,SCL-90-R ,Sample size determination ,Sample Size ,lcsh:Q ,Sleep Disorders ,COLLECTION ,business - Abstract
Before organizing mixed-mode data collection for the self-administered questionnaire of the Belgian Health Interview Survey, measurement effects between the paper-and-pencil and the web-based questionnaire were evaluated. A two-period cross-over study was organized with a sample of 149 employees of two Belgian research institutes (age range 22-62 years, 72% female). Measurement agreement was assessed for a diverse range of health indicators related to general health, mental and psychosocial health, health behaviors and prevention with kappa coefficients and intraclass correlation (ICC). The quality of the data collected by both modes was evaluated by quantifying the missing, 'don't know' and inconsistent values and data entry mistakes. Good to very good agreement was found for all categorical indicators with kappa coefficients superior to 0.60, except for two mental and psychosocial health indicators namely the presence of a sleeping disorder and of a depressive disorder (kappa≥0.50). For the continuous indicators high to acceptable agreement was observed with ICC superior to 0.70. Inconsistent answers and data-entry mistakes were only occurring in the paper-and-pencil mode. There were no less missing values in the web-based mode compared to the paper-and-pencil mode. The study supports the idea that web-based modes provide, in general, equal responses to paper-and-pencil modes. However, health indicators based upon factual and objective items tend to have higher measurement agreement than indicators requiring an assessment of personal subjective feelings. A web-based mode greatly facilitates the data-entry process and guides the completing of a questionnaire. However, item non-response was not positively affected. ispartof: PLOS ONE vol:13 issue:5 ispartof: location:United States status: published
- Published
- 2018
34. Children’s Attributional Style From Middle Childhood to Early Adolescence: Further Validation of the Paper-and-Pencil Versions of the Children’s Attributional Style Interview
- Author
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Sandra Yu Rueger, Beth A. Haines, and Christine Kerres Malecki
- Subjects
Male ,Paper ,Adolescent ,Psychometrics ,Writing ,Early adolescence ,Statistics as Topic ,Psychology, Child ,Factor structure ,Middle childhood ,Developmental psychology ,Helplessness, Learned ,Predictive Value of Tests ,Surveys and Questionnaires ,Interview, Psychological ,Humans ,Child ,Applied Psychology ,Pencil (mathematics) ,Analysis of Variance ,Depression ,Age Factors ,Cognition ,Affect ,Clinical Psychology ,Attitude ,Convergent validity ,Feasibility Studies ,Female ,Attribution ,Psychology ,Clinical psychology - Abstract
The psychometric properties of two paper-and-pencil versions of the Children’s Attributional Style Interview (i.e., CASI-I and CASI-II) were evaluated in a sample of 166 third and fourth graders and a sample of 245 sixth and seventh graders. The results demonstrated strong internal consistency reliability, convergent validity, and a factor structure that was consistent with theory in both samples. Furthermore, analyses demonstrated adequate evidence of the reliability and validity of several dimensional subscale scores and the composite measures of attributional style for both positive and negative events. These results suggest the utility of the CASI in research testing specific attributional predictions of cognitive theories of depression with the dimensional subscale scores. They further add to the literature by demonstrating item-level factor analytic support for a children’s attributional style measure and the feasibility of administration sizes larger than previously tested, which add to the utility of the CASI in large-scale research designs.
- Published
- 2009
35. Comparison of Internet-Based and Paper-Based Questionnaires in Taiwan Using Multisample Invariance Approach
- Author
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Min-Ning Yu and Sen-Chi Yu
- Subjects
Paper ,Psychometrics ,education ,Applied psychology ,Taiwan ,Models, Psychological ,Structural equation modeling ,Internet based ,Surveys and Questionnaires ,Humans ,Applied Psychology ,Language ,Psychometry ,Internet ,Depression ,business.industry ,Research ,Communication ,General Medicine ,Paper based ,Human-Computer Interaction ,The Internet ,business ,Psychology ,Social psychology - Abstract
This study examines whether the Internet-based questionnaire is psychometrically equivalent to the paper-based questionnaire. A random sample of 2,400 teachers in Taiwan was divided into experimental and control groups. The experimental group was invited to complete the electronic form of the Chinese version of Center for Epidemiologic Studies Depression Scale (CES-D) placed on the Internet, whereas the control group was invited to complete the paper-based CES-D, which they received by mail. The multisample invariance approach, derived from structural equation modeling (SEM), was applied to analyze the collected data. The analytical results show that the two groups have equivalent factor structures in the CES-D. That is, the items in CES-D function equivalently in the two groups. Then the equality of latent mean test was performed. The latent means of "depressed mood," "positive affect," and "interpersonal problems" in CES-D are not significantly different between these two groups. However, the difference in the "somatic symptoms" latent means between these two groups is statistically significant at alpha = 0.01. But the Cohen's d statistics indicates that such differences in latent means do not apparently lead to a meaningful effect size in practice. Both CES-D questionnaires exhibit equal validity, reliability, and factor structures and exhibit a little difference in latent means. Therefore, the Internet-based questionnaire represents a promising alternative to the paper-based questionnaire.
- Published
- 2007
36. Long term follow-up of the first 70 operated adults in the Goteborg Epilepsy Surgery Series with respect to seizures, psychosocial outcome and use of antiepileptic drugs
- Author
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Gerd Ekstedt, Fredrik Asztely, Kristina Malmgren, and Bertil Rydenhag
- Subjects
Adult ,Male ,Paper ,medicine.medical_specialty ,Time Factors ,Adolescent ,medicine.medical_treatment ,Poison control ,Neurosurgical Procedures ,Temporal lobe ,Central nervous system disease ,Epilepsy ,Injury prevention ,medicine ,Humans ,Psychology ,Epilepsy surgery ,Child ,Aged ,Depression ,business.industry ,Infant ,Middle Aged ,medicine.disease ,Surgery ,Psychiatry and Mental health ,Treatment Outcome ,Anticonvulsant ,Child, Preschool ,Quality of Life ,Anticonvulsants ,Female ,Neurology (clinical) ,business ,Psychosocial ,Follow-Up Studies - Abstract
Objective: To compare long term (10 years) seizure outcome, psychosocial outcome and use of antiepileptic drugs (AED) with the 2 year follow-up in adults after resective epilepsy surgery. Methods: All adults (n = 70) who underwent resective epilepsy surgery from 1987 to 1995 in the Goteborg Epilepsy Surgery Series were included. Fifty-four had undergone temporal lobe resections and 16 extratemporal resections (12 frontal). A cross-sectional follow-up in the form of a semistructured interview was performed in late 2003. Results: Mean follow-up was 12.4 years (range 8.6–16.2). Of the 70 patients (51% males), five (7%) were dead (three as a result of non-epilepsy related causes). Of the 65 patients interviewed, 38 (58%) were seizure-free at the long term follow-up: 65% of the patients with temporal lobe resections and 36% of the patients with extratemporal resections. Of the 35 patients who were seizure-free at the 2 year follow-up, 3 (9%) had seizures at the long term follow-up. Of the 30 patients who had seizures at the 2 year follow-up, 6 (20%) were seizure-free at the long term follow-up. Of all 65 patients, 45 (69%) had the same seizure status as the 2 year follow-up. Sixteen (25%) had an improved seizure status and 4 (6%) had a worsened status. Of the seizure-free patients, 11 (29%) had ceased taking AED, 28 (74%) were working and 25 (66%) had a driving license. Conclusions: Adult patients who are seizure-free 2 years after resective epilepsy surgery are most likely to still be seizure-free 10 years later. Most are working and have obtained a driving license.
- Published
- 2007
37. The effect of the apolipoprotein E gene polymorphisms and haplotypes on behavioural and psychological symptoms in probable Alzheimer's disease
- Author
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Peter Bentham, Corinne Lendon, Sayeed Haque, Colin W. Pritchard, Judith Harris, Roger Holder, John Coates, and Antonia L. Pritchard
- Subjects
Male ,Paper ,Apolipoprotein E ,medicine.medical_specialty ,Hallucinations ,Apolipoprotein E4 ,Disease ,Anxiety ,Bioinformatics ,Irritability ,Exon ,Degenerative disease ,Alzheimer Disease ,medicine ,Humans ,Dementia ,Longitudinal Studies ,Psychiatry ,Aged ,Aged, 80 and over ,Polymorphism, Genetic ,Depression ,Haplotype ,Middle Aged ,medicine.disease ,Aggression ,Psychiatry and Mental health ,Haplotypes ,Female ,Surgery ,Neurology (clinical) ,medicine.symptom ,Alzheimer's disease ,Psychology - Abstract
Background: Patients with Alzheimer’s disease and dementia commonly suffer from behavioural and psychological symptoms of dementia (BPSD). A genetic component to BPSD development in Alzheimer’s disease has been demonstrated. Several studies have investigated whether the exon 4 e2/e3/e4 haplotype of the apolipoprotein E ( APOE ) gene is associated with BPSD, with variable results. Objective: We investigated the exon 4 polymorphisms and extended this study to include promoter polymorphisms and the resultant haplotypes across the gene. Methods: Our large independent cohort of 388 patients with longitudinal measures of BPSD assessed by the Neuropsychiatric Inventory was used to analyse whether any of these variants were associated with the presence of BPSD. Results: We revealed several significant relationships before correction for multiple testing. The exon 4 haplotype was associated with hallucinations and anxiety, A-491T with irritability, T-427C with agitation/aggression and appetite disturbances, and T-219C with depression. Haplotype analyses of all variants did not reveal any statistically significant findings. Conclusions: Our data and a review of previous studies showed a diversity of relationships, suggesting that these findings might be due to chance and so collectively do not support a role for the APOE gene in BPSD.
- Published
- 2007
38. Web-based cognitive training for breast cancer survivors with cognitive complaints-a randomized controlled trial
- Author
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RK Andreasen, Malene Flensborg Damholdt, O'Toole, Anders Degn Pedersen, Mimi Mehlsen, and Robert Zachariae
- Subjects
Adult ,Paper ,breast cancer survivors ,education ,Experimental and Cognitive Psychology ,Breast Neoplasms ,chemo brain ,Anxiety ,Neuropsychological Tests ,Verbal learning ,law.invention ,web‐based cognitive training ,03 medical and health sciences ,Executive Function ,0302 clinical medicine ,Randomized controlled trial ,Cancer Survivors ,law ,Surveys and Questionnaires ,Medicine ,Humans ,cancer ,030212 general & internal medicine ,Cognitive skill ,Internet ,Working memory ,business.industry ,Depression ,Neuropsychology ,Cognition ,Middle Aged ,medicine.disease ,Cognitive training ,Psychiatry and Mental health ,Memory, Short-Term ,030220 oncology & carcinogenesis ,Papers ,oncology ,Female ,business ,Chemo brain ,Clinical psychology - Abstract
Background Cognitive complaints are common amongst breast cancer survivors, and no standard treatment exists. The present study evaluates whether web-based cognitive training can alleviate subjectively reported and objectively assessed cognitive complaints in a sample of breast cancer survivors. The primary and secondary outcomes were an objective measure of working memory and a measure of perceived cognitive functioning. Additional outcomes were neuropsychological tests of memory, executive function, working memory and questionnaire-based assessment of anxiety, depression and somatization. Methods A total of 157 female breast cancer survivors were recruited from an existing cohort and through announcements in open access cancer-related Internet fora and randomly allocated to either web-based cognitive training (eCogT) with telephone support (n = 94) or a waitlist control (WLC) condition (n = 63). eCogT encompassed 30 training sessions over 6 weeks. Neuropsychological assessments were undertaken over the telephone, and questionnaire data was collected online. Data was collected at baseline, post-intervention and at 5-month follow-up. Results Mixed linear models revealed no statistically significant change in primary or secondary outcome at follow-up in either group. Statistically significant improvements (p 0.040–0.043) were found in the eCogT group for verbal learning and on a working memory test. Conclusions Web-based cognitive training did not result in improvements of the primary or secondary outcome. Improved performance was observed on verbal learning and working memory. These effects were observed at 5-month follow-up, indicating long-term effects of training. The intervention may be applied in a clinical setting at low cost and without risk of adverse effects. © 2016 The Authors. Psycho-Oncology Published by John Wiley & Sons Ltd.
- Published
- 2015
39. The impact of a cancer diagnosis on health and well-being: a prospective, population-based study
- Author
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Kate, Williams, Sarah E, Jackson, Rebecca J, Beeken, Andrew, Steptoe, and Jane, Wardle
- Subjects
Adult ,Male ,Paper ,longitudinal ,Depression ,Health Status ,Middle Aged ,quality of life ,Neoplasms ,Activities of Daily Living ,Papers ,oncology ,Humans ,cancer ,Female ,Longitudinal Studies ,Prospective Studies ,Survivors ,survivorship ,Aged - Abstract
Objective Little is known about the trajectory of health and well‐being from before to after a cancer diagnosis. This study aimed to examine changes in health and well‐being across three time points (0–2 years before a cancer diagnosis, 0–2 years post‐diagnosis and 2–4 years post‐diagnosis) in individuals receiving a new cancer diagnosis, and at matched time points in a cancer‐free comparison group. Methods Data were from waves 1–6 of the English Longitudinal Study of Ageing. Repeated‐measures ANOVAs were used to examine differences in self‐rated health, mobility impairments, activities of daily living impairments, quality of life, depressive symptoms and life satisfaction by group and time, and group‐by‐time interactions. Results Of the 4565 participants with data from three time points, 444 (9.7%) reported a new cancer diagnosis. Those in the cancer group reported poorer self‐rated health (p
- Published
- 2015
40. A diagnostic formulation for anosognosia in Alzheimer's disease
- Author
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R. G. Robinson, Ricardo E. Jorge, Sergio E. Starkstein, and Romina Mizrahi
- Subjects
Paper ,Male ,medicine.medical_specialty ,Activities of daily living ,Psychometrics ,Denial, Psychological ,Severity of Illness Index ,Alzheimer Disease ,Activities of Daily Living ,Severity of illness ,medicine ,Humans ,Dementia ,Apathy ,Psychiatry ,Depression (differential diagnoses) ,Aged ,Aged, 80 and over ,Depression ,Anosognosia ,Memory clinic ,Reproducibility of Results ,Middle Aged ,medicine.disease ,Inhibition, Psychological ,Psychiatry and Mental health ,Caregivers ,Case-Control Studies ,Agnosia ,Female ,Surgery ,Neurology (clinical) ,Alzheimer's disease ,medicine.symptom ,Psychology ,human activities - Abstract
Objective: To determine the earliest symptoms of anosognosia in people with Alzheimer’s disease and to validate a criteria-guided strategy to diagnose anosognosia in dementia. Methods: A consecutive series of 750 patients with very mild or probable Alzheimer’s disease attending a memory clinic, as well as their respective care givers, was assessed using a comprehensive psychiatric evaluation. Results: The factors of anosognosia for (1) basic activities of daily living (bADL), (2) instrumental activities of daily living (iADL), (3) depression and (4) disinhibition were produced by a principal component analysis on the differential scores (ie, caregiver score minus patient score) on the anosognosia questionnaire for dementia. A discrepancy of two or more points in the anosognosia-iADL factor was found to have a high sensitivity and specificity to identify clinically diagnosed anosognosia in people with Alzheimer’s disease. By logistic regression analysis, the severity of dementia and apathy were both shown to be noticeably associated with anosognosia in people with Alzheimer’s disease. Conclusion: Anosognosia in those with Alzheimer’s disease is manifested as poor awareness of deficits in iADL and bADL, depressive changes and behavioural disinhibition. The frequency of anosognosia is found to increase considerably with the severity of dementia. The validity of a specific set of criteria to diagnose anosognosia in people with Alzheimer’s disease was shown, which may contribute to the early identification of this condition.
- Published
- 2006
41. A prospective longitudinal study of apathy in Alzheimer's disease
- Author
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R. G. Robinson, Ricardo E. Jorge, Sergio E. Starkstein, and Romina Mizrahi
- Subjects
Paper ,Male ,Longitudinal study ,medicine.medical_specialty ,Disease ,Neuropsychological Tests ,Alzheimer Disease ,Surveys and Questionnaires ,medicine ,Humans ,Dementia ,Apathy ,Prospective Studies ,Prospective cohort study ,Psychiatry ,Depression (differential diagnoses) ,Aged ,Depression ,Cognition ,medicine.disease ,Psychiatry and Mental health ,Female ,Surgery ,Neurology (clinical) ,Alzheimer's disease ,medicine.symptom ,Cognition Disorders ,Psychology ,Follow-Up Studies - Abstract
Apathy and depression are the most frequent behavioural and psychiatric disorders in Alzheimer's disease, and may both have a negative impact on the progression of the illness.To examine the clinical correlates of apathy in Alzheimer's disease (AD), and to determine whether apathy is a significant predictor of more rapid cognitive, functional and emotional decline.Using a structured psychiatric evaluation, we examined a consecutive series of 354 subjects meeting clinical criteria for AD. Apathy was assessed by the Apathy Scale, and diagnosed using standardised criteria. Additional measurements included scales for depression, functional impairment, and global cognitive functions. A follow up evaluation was carried out in 247 patients (70% of the total sample) between 1 and 4 years after the baseline evaluation.Apathy was significantly associated with older age (p = 0.009), and a higher frequency of minor and major depression (p0.0001). Apathy at baseline was a significant predictor of depression at follow up (p = 0.01), and was associated with a faster cognitive (p = 0.0007) and functional decline (p = 0.006).Apathy in AD is a behavioural marker of a more aggressive dementia, characterised by a faster progression of cognitive, functional, and emotional impairment.
- Published
- 2006
42. Amantadine for treatment of fatigue in Guillain-Barre syndrome: a randomised, double blind, placebo controlled, crossover trial
- Author
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Bart C. Jacobs, F. G. A. Van Der Meche, P. I. M. Schmitz, P.A. van Doorn, Marcel P. J. Garssen, I.S.J. Merkies, Neurology, and Hematology
- Subjects
Adult ,Male ,Paper ,medicine.medical_specialty ,Neuromuscular disease ,Anxiety ,Placebo ,Guillain-Barre Syndrome ,Antiviral Agents ,Quality of life ,Double-Blind Method ,Internal medicine ,medicine ,Amantadine ,Humans ,Depression (differential diagnoses) ,Fatigue ,Aged ,Aged, 80 and over ,Cross-Over Studies ,Guillain-Barre syndrome ,business.industry ,Depression ,Middle Aged ,medicine.disease ,Crossover study ,Psychiatry and Mental health ,Physical therapy ,Quality of Life ,Surgery ,Female ,Neurology (clinical) ,medicine.symptom ,business ,medicine.drug - Abstract
Objective: Fatigue is a major complaint in patients with immune mediated polyneuropathies. Despite apparently good physical recovery after Guillain-Barre syndrome (GBS), many patients remain restricted in daily and social activities, and have a decreased quality of life. In this trial, the effect of amantadine on severe fatigue related to GBS was studied. Methods: During the pre-treatment phase, all patients were monitored for 2 weeks. Only patients with severe fatigue, defined as a mean fatigue score of ≥5.0 on the Fatigue Severity Scale (FSS), were randomised for this double blind, placebo controlled, crossover study. Primary outcome measure was improvement of at least 1 point on the FSS. Secondary outcome measures were impact of fatigue, anxiety and depression, handicap, and quality of life. Results: In total, 80 patients with GBS were randomised, of whom 74 were included for analysis. Fatigue appeared to be reduced already during the pre-treatment phase (p = 0.05), probably due to increased attention provided to the patients. No significant differences in any of the primary and secondary outcome measures were found. Conclusions: Amantadine was not superior to placebo. Because fatigue remains a serious complaint, other studies evaluating new treatment options are strongly recommended.
- Published
- 2006
43. Development of health-related quality of life and symptoms of anxiety and depression among persons diagnosed with cancer during adolescence: a 10-year follow-up study
- Author
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Helena Grönqvist, Gunn Engvall, Martin Cernvall, Johan Lyhagen, Gustaf Ljungman, Louise von Essen, Malin Ander, Elisabet Mattsson, and Mariann Hedström
- Subjects
Adult ,Male ,Paper ,medicine.medical_specialty ,Time Factors ,Adolescent ,Alternative medicine ,Experimental and Cognitive Psychology ,Anxiety ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Neoplasms ,Surveys and Questionnaires ,Medicine ,Humans ,030212 general & internal medicine ,Survivors ,Psychiatry ,Depression (differential diagnoses) ,Health related quality of life ,Psychiatric Status Rating Scales ,Cancer och onkologi ,Psykologi (exklusive tillämpad psykologi) ,business.industry ,10 year follow up ,Depression ,Cancer ,medicine.disease ,humanities ,Psychology (excluding Applied Psychology) ,Psychiatry and Mental health ,Mental Health ,Oncology ,030220 oncology & carcinogenesis ,Cancer and Oncology ,Cohort ,Papers ,Quality of Life ,Female ,medicine.symptom ,business ,Follow-Up Studies - Abstract
Objective The main aim was to investigate the development of health‐related quality of life (HRQOL) and symptoms of anxiety and depression in a cohort diagnosed with cancer during adolescence from shortly after up to 10 years after diagnosis. Methods Participants (n = 61) completed the SF‐36 and the HADS shortly; six, 12, and 18 months; and two, three, four, and 10 years (n = 28) after diagnosis. Polynomial change trajectories were used to model development. Results Polynomial change trajectories showed an initial increase which abated over time into a decrease which abated over time for the SF‐36 subscales Mental Health and Vitality; an initial decline which abated over time into an increase for HADS anxiety; and an initial decline which abated over time into an increase which abated over time for HADS depression. The SF‐36 mental component summary showed no change from two to 10 years after diagnosis whereas the SF‐36 physical component summary showed an increase from two years after diagnosis which declined over time. Ten years after diagnosis 29% reported possible anxiety. Conclusions Development of HRQOL and symptoms of anxiety and depression appears to be non‐linear among persons diagnosed with cancer during adolescence. Well into permanent survivorship an increase in symptoms of anxiety is shown and approximately a third of the participants report possible anxiety. The findings indicate the need for: studies designed to pinpoint the times of highest psychological risk, clinical follow‐up focusing on psychological problems, and development of effective psychological interventions for survivors of adolescent cancer. © 2015 The Authors. Psycho‐Oncology published by John Wiley & Sons Ltd.
- Published
- 2014
44. Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach
- Author
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Simon J.G. Lewis, Thomas Foltynie, Roger A. Barker, Andrew D. Blackwell, Adrian M. Owen, and Trevor W. Robbins
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Male ,Paper ,medicine.medical_specialty ,Parkinson's disease ,Disease ,Developmental psychology ,Cohort Studies ,Diagnosis, Differential ,Central nervous system disease ,Reference Values ,Internal medicine ,Tremor ,Correspondence ,medicine ,Humans ,Dementia ,Age of Onset ,Aged ,Depression ,Parkinson Disease ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Mood ,Cohort ,Female ,Surgery ,Neurology (clinical) ,Age of onset ,Cognition Disorders ,Psychology ,Cohort study - Abstract
Objective: To investigate the heterogeneity of idiopathic Parkinson's disease (PD) in a data driven manner among a cohort of patients in the early clinical stages of the disease meeting established diagnostic criteria. Methods: Data on demographic, motor, mood, and cognitive measures were collected from 120 consecutive patients in the early stages of PD (Hoehn and Yahr I–III) attending a specialist PD research clinic. Statistical cluster analysis of the data allowed the existence of the patient subgroups generated to be explored. Results: The analysis revealed four main subgroups: (a) patients with a younger disease onset; (b) a tremor dominant subgroup of patients; (c) a non-tremor dominant subgroup with significant levels of cognitive impairment and mild depression; and (d) a subgroup with rapid disease progression but no cognitive impairment. Conclusions: This study complements and extends previous research by using a data driven approach to define the clinical heterogeneity of early PD. The approach adopted in this study for the identification of subgroups of patients within Parkinson's disease has important implications for generating testable hypotheses on defining the heterogeneity of this common condition and its aetiopathological basis and thus its treatment.
- Published
- 2005
45. Personality change after stroke: some preliminary observations
- Author
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Ellen Townend, Kristin Haga, Joseph Kwan, Jon Stone, Michael Sharpe, and Martin Dennis
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Paper ,Male ,medicine.medical_specialty ,Activities of daily living ,Psychometrics ,health care facilities, manpower, and services ,media_common.quotation_subject ,Anxiety ,Hospital Anxiety and Depression Scale ,Personality Disorders ,Activities of Daily Living ,medicine ,Humans ,Personality ,Prospective Studies ,skin and connective tissue diseases ,Psychiatry ,Stroke ,health care economics and organizations ,Aged ,media_common ,Aged, 80 and over ,Depression ,social sciences ,Middle Aged ,medicine.disease ,Personality disorders ,Psychiatry and Mental health ,Caregivers ,Female ,Surgery ,sense organs ,Neurology (clinical) ,Psychiatric interview ,medicine.symptom ,Tomography, X-Ray Computed ,Psychology ,Clinical psychology - Abstract
OBJECTIVES: To describe changes in personality after stroke and effects on carers. METHODS: A consecutive series of patients was recruited from hospital admissions with stroke. A novel questionnaire was administered to the patients' main carer at nine months after the stroke to determine their perception of the patients' pre-stroke and post-stroke personality. Personality change was identified by changes in these ratings, and associations between personality change and the following variables explored: emotional disorder in patients and carers (measured using the hospital anxiety and depression scale and a structured psychiatric interview), stroke classification (Oxford community stroke classification), residual disability (Barthel index and Nottingham extended activities of daily living scale), and lesion characteristics on computed tomography (CT). RESULTS: Carers of 35 patients with stroke took part. Reported changes in personality after stroke included: reduced patience and increased frustration (both p
- Published
- 2004
46. Psychosocial outcomes at 18 months after good neurological recovery from aneurysmal subarachnoid haemorrhage
- Author
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Neil Kitchen, Richard Greenwood, J Heslin, and Jane H. Powell
- Subjects
Adult ,Employment ,Male ,Paper ,medicine.medical_treatment ,Stress Disorders, Post-Traumatic ,Activities of Daily Living ,medicine ,Memory span ,Humans ,Verbal fluency test ,cardiovascular diseases ,Depression (differential diagnoses) ,Aged ,Aged, 80 and over ,Rehabilitation ,Depression ,Mood Disorders ,Middle Aged ,Subarachnoid Hemorrhage ,medicine.disease ,nervous system diseases ,Psychiatry and Mental health ,Treatment Outcome ,Mood ,Mood disorders ,Case-Control Studies ,Anxiety ,Female ,Surgery ,Neurology (clinical) ,medicine.symptom ,Cognition Disorders ,Psychology ,Psychosocial ,Follow-Up Studies ,Clinical psychology - Abstract
Objectives: To evaluate functioning, 18 months after surgery, of 49 patients with good neurological recovery following aneurysmal subarachnoid haemorrhage (SAH), and to determine the extent of any improvements in disturbances of mood, cognitive functioning, and levels of activity and participation previously observed at 9 month follow up. Methods: SAH patients, matched for age, gender, and occupation with healthy control participants, completely quantitative measures of mood (HADS, FIES, BDI) and activity/participation (BICRO-39 scales), and a brief cognitive assessment battery (verbal fluency, digit span, prose recall). Controls completed the HADS and the BICRO-39. Results: Patients showed some recovery of cognitive functioning, though impairments of prose recall persisted. Anxiety and depression symptoms were higher in patients than in controls, but fewer than 20% scored in the clinical range on any questionnaires except for RIES-Intrusive thoughts (22%); only three showed signs of full blown post-traumatic stress disorder. Almost half showed elevated dependence on others for domestic activities and organisation and abnormally low levels of employment. Very little variance in outcome was predicted by demographic variables, neurological or cognitive impairment, prior life stress, or mood. However, levels of social activity and self-organisation were related to persisting fatigue. Conclusions: The observed decline in intrusive thoughts and avoidance over time is consistent with that seen after life threatening illness or trauma. The persistent reductions in independence and levels of employment may in some cases reflect considered lifestyle adjustments rather than adverse and unwanted changes but in others indicate a need for focused rehabilitation.
- Published
- 2004
47. Cerebral haemodynamics and depression in the elderly
- Author
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Monique M.B. Breteler, Henning Tiemeier, Peter J. Koudstaal, S. L. M. Bakker, and Albert Hofman
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Male ,Paper ,medicine.medical_specialty ,Ultrasonography, Doppler, Transcranial ,Hemodynamics ,Rotterdam Study ,Risk Factors ,Internal medicine ,medicine.artery ,Odds Ratio ,medicine ,Humans ,Stroke ,Depression (differential diagnoses) ,Aged ,Netherlands ,Depression ,business.industry ,Odds ratio ,Middle Aged ,Late life depression ,medicine.disease ,Psychiatry and Mental health ,Cross-Sectional Studies ,Cerebral blood flow ,Research Design ,Cerebrovascular Circulation ,Anesthesia ,Middle cerebral artery ,Cardiology ,Female ,Surgery ,Neurology (clinical) ,business ,Blood Flow Velocity - Abstract
Background: Evidence from epidemiological and neuroimaging studies suggests that cerebrovascular disease is associated with depressive disorders in the elderly, but the extent to which it contributes to the pathogenesis of late life depression is unclear. Objective: To investigate the relation between cerebral haemodynamics and depression in a population based study, using transcranial Doppler ultrasonography. Methods: Cerebral blood flow velocity and CO 2 induced vasomotor reactivity in the middle cerebral artery were measured in 2093 men and women who participated in the Rotterdam study. All subjects were screened for depressive symptoms using the Center of Epidemiological Studies Depression scale, and those with a score of 16 or over had a psychiatric work up. In a semistructured interview, diagnoses of depressive disorders according to the DSM-IV and subthreshold depressive disorder were established. Analyses of covariance controlled for age, sex, stroke, cognitive score, and cardiovascular risk factors were used to compare means of haemodynamic variables. Results: Subjects with depressive symptoms had reduced blood flow velocities (mean difference, −2.9 cm/s; 95% confidence interval (CI), −5.0 to −0.8; p = 0.008) and lower vasomotor reactivity (mean difference −0.5%/kPa; 95% CI, −1.0 to −0.05; p = 0.03). Blood flow velocity was reduced most in subjects suffering from a DSM-IV depressive disorder (mean difference, −4.9 cm/s; 95% CI, −8.5 to −1.4; p = 0.006). The overall reduction in vasomotor reactivity was accounted for by subjects with subthreshold depressive disorder. Conclusions: Depression in late life is associated with cerebral haemodynamic changes that can be assessed by transcranial Doppler ultrasonography. The observed reduction in cerebral blood flow velocity could be a result of reduced demand in more seriously depressed cases with a DSM-IV disorder, whereas reduced CO 2 induced cerebral vasomotor reactivity is a possible causal factor for subthreshold depressive disorder.
- Published
- 2002
48. Enduring increased risk of developing depression and mania in patients with dementia
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Flemming Mørkeberg Nilsson, Tom G. Bolwig, Per Kragh Andersen, Lars Vedel Kessing, and Tine Moller Sorensen
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Paper ,Male ,Risk ,Research design ,medicine.medical_specialty ,Bipolar Disorder ,Time Factors ,genetic structures ,behavioral disciplines and activities ,Cohort Studies ,mental disorders ,Epidemiology ,medicine ,Humans ,Dementia ,Poisson Distribution ,Bipolar disorder ,Psychiatry ,Depression (differential diagnoses) ,Aged ,Aged, 80 and over ,Depression ,Incidence (epidemiology) ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Research Design ,behavior and behavior mechanisms ,Female ,Surgery ,Neurology (clinical) ,medicine.symptom ,Psychology ,Mania ,Cohort study - Abstract
Objective: To investigate the time relation between dementia and major affective disorders (major depression and mania). Methods: Register linkage study of the Danish Hospital Register and the Danish Psychiatric Central Research Register, to establish study cohorts of patients with dementia and control groups (osteoarthritis or diabetes) on first discharge from hospital. Follow up of cohorts was for up to 21 years. Hazard of death was allowed for by the use of competing risks models. Results: Patients with dementia had an increased risk of being admitted to hospital for major depression or mania during the course of the illness. The incidence remained elevated throughout the rest of the patient's life. Conclusions: Patients with dementia have an increased risk of developing depression or mania. Proper treatment of affective disorders in patients with dementia is important in reducing suffering and costs.
- Published
- 2002
49. Behavioural disorders, Parkinson's disease and subthalamic stimulation
- Author
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Luc Mallet, Philippe Cornu, Didier Dormont, Marcela Gargiulo, Bernard Pidoux, Valérie Mesnage, J.-L. Houeto, A. M. Bonnet, Bernard Pillon, Yves Agid, and S. Tezenas du Moncel
- Subjects
Paper ,Male ,medicine.medical_specialty ,Substance-Related Disorders ,Adjustment disorders ,Electric Stimulation Therapy ,Anxiety ,Personality changes ,Subthalamic Nucleus ,Correspondence ,medicine ,Humans ,Decompensation ,Social Behavior ,Psychiatry ,Depression (differential diagnoses) ,Dopamine dysregulation syndrome ,Depression ,Parkinson Disease ,Middle Aged ,medicine.disease ,Personality disorders ,nervous system diseases ,Motor Skills Disorders ,Psychiatry and Mental health ,surgical procedures, operative ,Treatment Outcome ,nervous system ,Quality of Life ,Female ,Surgery ,Neurology (clinical) ,Psychiatric interview ,medicine.symptom ,Mental Status Schedule ,Psychology ,therapeutics ,Personality ,Clinical psychology - Abstract
Objective: to analyse 24 parkinsonian patients successfully treated by bilateral STN stimulation for the presence of behavioural disorders. Method: patients were evaluated retrospectively for adjustment disorders (social adjustment scale, SAS), psychiatric disorders (comparison of the results of psychiatric interview and the mini international neuropsychiatric inventory) and personality changes (IOWA scale of personality changes). Results: parkinsonian motor disability was improved by 69.5% and the levodopa equivalent daily dosage was reduced by 60.5%. Social adjustment (SAS) was considered good or excellent in nine patients, moderately (n=14), or severely (n=1) impaired in 15 patients. Psychiatric disorders consisted of amplification or decompensation of previously existing disorders that had sometimes passed unnoticed, such as depressive episodes (n=4), generalised anxiety (n=18), and behavioural disorders with drug dependence (n=2). Appearance of mild to moderate emotional hyperreactivity was reported in 15 patients. Personality traits (IOWA scale) were improved in eight patients, unchanged in seven, and aggravated in eight Conclusion: Improvement in parkinsonian motor disability induced by STN stimulation is not necessarily accompanied by improvement in psychic function and quality of life. Attention is drawn to the possible appearance of personality disorders and decompensation of previous psychiatric disorders in parkinsonian patients who are suitable candidates for neurosurgery. We suggest that a careful psychological and psychiatric interview be performed before surgery, and emphasise the need for psychological follow up to ensure the best possible outcome.
- Published
- 2002
50. What are the determinants of quality of life in people with cervical dystonia?
- Author
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Laura Camfield, Thomas T. Warner, and Yoav Ben-Shlomo
- Subjects
Paper ,Male ,medicine.medical_specialty ,SF-36 ,Disease ,Anxiety ,Severity of Illness Index ,Social support ,Cognition ,Quality of life ,Adaptation, Psychological ,Severity of illness ,otorhinolaryngologic diseases ,medicine ,Humans ,Cervical dystonia ,Psychiatry ,Torticollis ,Dystonia ,Depression ,Social Support ,Middle Aged ,medicine.disease ,nervous system diseases ,Psychiatry and Mental health ,Cross-Sectional Studies ,Quality of Life ,Female ,Surgery ,Neurology (clinical) ,medicine.symptom ,Psychology - Abstract
Background: Little is known about the quality of life in patients with cervical dystonia, although pain and depression are relatively common. Objective: To test the hypothesis that an individual’s ability to cope with the disease will modify the association of intrinsic, extrinsic, and disease related factors with quality of life. Methods: Patients with cervical dystonia diagnosed by a movement disorder specialist were recruited from seven European countries. Data on quality of life (SF-36), measures of coping, and intrinsic, extrinsic, and disease related factors were collected by a self completed postal questionnaire. Results: 289 patients (101 men and 188 women), mean age 55 years, completed the questionnaire. Both physical and mental quality of life scores were predicted by self esteem and self deprecation, educational level, employment status, social support, response to botulinum toxin, disease severity, social participation, stigma, acceptance of illness, anxiety, and depression. In multivariable analyses, the strongest predictors were anxiety and depression. Severe depression was associated with a 19.1 point decrement in the physical summary score (95% confidence interval, -31.7 to -6.6; p = 0.003); however, disease duration and severity remained predictors. Conclusions: Care for patients with cervical dystonia must not only focus on reducing the severity of the dystonia but also on the psychological wellbeing of the patient. Interventions aimed at treating depression or anxiety, especially of a cognitive nature, may have a large impact on improving quality of life.
- Published
- 2002
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