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Research to date has convincingly demonstrated that nutrition impacts depression. Population-based studies have shown that diet, food types, dietary supplements, gut bacteria, endocrine systems and obesity all play a role in depression. While nutrition could provide an important therapeutic opportunity in depression, clinical trials have not shown clinically meaningful results, and it appears unlikely that nutrition is a central determinant of depression. Conversely, however, prior research is inconclusive to inferring that nutrition does not have a clinically significant effect. This would require elucidating precisely when nutrition affects depression which necessitates an alternative, more granular, model for the nutrition–depression interaction. The network theory of mental disorders, which studies how mental disorders arise from a causally related network of symptoms and external factors, is proposed as an alternative model for understanding the complexity of the nutrition–depression link. This approach would uncover which relationships, between aspects of nutrition and depression symptoms, warrant further study at a population and laboratory level. Furthermore, from within nutrition science, is a movement dubbed ‘New Nutrition Science’ (NNS) that aims to integrate biological, social and environmental determinants of nutrition. NNS is important to nutrition–depression research which has yet to reveal how social factors impact the nutrition–depression interaction. Network theory methodology is fully compatible with the network modelling already used in NNS. Embracing both network theory and NNS in future research will develop a full and complex understanding of nutrition in depression.