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Aims: The purpose of this study was to determine the relationship between nurses' anxiety and depression levels and their compliance with isolation measures during the COVID-19 pandemic. Background: The global COVID-19 pandemic has had severe psychological impacts on nurses. Methods: Following receipt of the requisite approvals, data were collected actively from 289 nurses consenting to participate in the study through an online questionnaire using theinternet/social media. Results: Mean stress, anxiety, and depression scores were higher among carers for COVID-19 patients than in non-Covidcarers. Analysis revealed significant positive correlation between Isolation Precautions Compliance Scale scores and stress, anxiety, depression, and burnout. Conclusion: Burnout increased while compliance with isolation precautions decreased in this study as stress, anxiety, and depression increased. [ABSTRACT FROM AUTHOR]