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Background: The inflammation and oxidative stress are thought to play an important role in the etiopathogenesis of some psychological disorders. We aimed to assess the potential relationships between serum fat soluble vitamins (Vitamins A and E), antibody titers to Hsp27 (anti-Hsp27) and hematological markers of inflammation, with mood disorders in a population of adolescent girls., Methods: A total of 563 adolescent girls (Age 12-18 years) were included in the study. The presence and severity of depression, insomnia and sleepiness were assessed using validated questionnaires. Serum vitamins A and E, anti-Hsp27 antibody titers, white blood cell, lymphocyte, neutrophil, platelet counts, and red blood cell distribution width (RDW), were also measured. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and RDW to platelet ratio (RPR) were calculated., Results: Serum anti-HSP27 antibody titers, PLR, and RPR values was significantly higher in subjects with a high depression score compared to normal individuals (p < 0.05). However, there was no association between serum inflammatory markers concentrations and sleep disorders; although individuals with insomnia had a lower vitamin E/HDL ratio compared to healthy adolescents. In multivariate logistic regression analyses adjusted for potential confounders, anti-HSP was an independent predictor of severe depression (OR = 5.0, 95% CI: 1.6-15.7, p < 0.05)., Limitation: The cross-sectional design of study and the inclusion of only female adolescents participants are limitations., Conclusion: Our findings suggest that serum anti-HSP27 antibody titers may be useful biological marker in depressive patients. This finding may support a role of oxidative stress in the etiology of depression, and targeting this pathway may be of value in the treatment of depression., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Background: Depression and anxiety are two common mood disorders that are both linked to systemic inflammation. Increased white blood cell (WBC) count and red cell distribution width (RDW) are associated with negative clinical outcomes in a wide variety of pathological conditions. WBC is a non-specific inflammatory marker and RDW is also strongly related to other inflammatory markers. Therefore, we proposed that there might be an association between these hematological inflammatory markers and depression/anxiety symptoms., Objective: The primary objective of this study was to examine the association between depression/anxiety symptoms and hematological inflammatory markers including WBC and RDW in a large population-based study., Methods: Symptoms of depression and anxiety and a complete blood count (CBC) were measured in 9274 participants (40% males and 60% females) aged 35-65 years, enrolled in a population-based cohort (MASHAD) study in north-eastern Iran. Symptoms of depression and anxiety were evaluated using the Beck Depression and Anxiety Inventories., Results: The mean WBC count increased with increasing severity of symptoms of depression and anxiety among men. Male participants with severe depression had significantly higher values of RDW (p<0.001); however, this relationship was less marked among women (p=0.004). In addition, men (but not women) with severe anxiety symptoms had significantly higher values of RDW (p<0.001). Moreover, there was a negative association between red blood cell (RBC) and mean corpuscular hemoglobin (MCH) and symptoms of depression/anxiety., Conclusion: Our results suggest that higher depression and anxiety scores are associated with an enhanced inflammatory state, as assessed by higher hematological inflammatory markers including WBC and RDW, even after adjusting for potential confounders., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Mental health disorders are linked to systemic inflammation. Due to high inflammation and mental health disorders in COVID‐19 patients, we aimed to investigate the relationship between blood inflammatory markers such as red cell distribution width to platelet ratio (RPR), platelet‐lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), red cell distribution width (RDW), white blood cell (WBC), and psychological function in COVID‐19 patients. In the current cross‐sectional study, neuro‐psychological function, and a complete blood count (CBC) were measured on 120 COVID‐19 patients aged >30 years from the Imam Reza Hospital in Mashhad, Iran. Our results showed that anxiety related to MCHC (mean ± SD: 32.71 ± 1.68, p < 0.05), WBC (mean ± SD: 12.23 ± 5.43, p < 0.05), and PLR (median (IQR): 28.72 (15.88–41.31), p < 0.05) significantly. In the stress subgroup, only RPR was associated with stress (p < 0.05). Linear regression between hematological parameters and psychological score indicated that RDW and PLR had a significantly positive association with depression (β = 0.086; p = 0.045 and β = 1.326; p = 0.016, respectively) and anxiety scores (β = 0.100; p = 0.038 and β = 1.356; p = 0.010, respectively). Moreover, a positive correlation was found between PLR and stress (β = 1.102; p = 0.012). This study showed a positive association between depression/anxiety/stress symptoms and levels of hematological inflammatory markers including PLR and RDW. The findings of this study provide novel insights into mental health and physiological markers, underscoring the potential influence of inflammation on mood disorders. Our findings offer exciting prospects for future research and may lead to innovative approaches in the management and treatment of depression, anxiety, and stress. [ABSTRACT FROM AUTHOR]

Introduction: The pandemic of COVID-19 created a psychological response. So, the psychological function of COVID-19 patients is an important subject that forces us to follow up with them. Aim: Assess the correlation between vitamin D serum concentrations and psychological functions such as insomnia, stress, and depression through the COVID-19 pandemic Methods: In this cross-sectional study, blood samples from 120 COVID-19 patients (61 males and 59 females) who had more than 30 years, were taken. Also, 25(OH)D Serum level of COVID-19 patients was analyzed. The Insomnia Severity Index (ISI), Depression anxiety stress scales (DASS), and the Short Form Health Survey (SF-36) were used to analyze insomnia, anxiety, stress, quality of life, and depression. Results: The relationship between temperature (p=0.039), PCO2 (p=0.022), and serum vitamin D level was significant. Additionally, there was a significant correlation between stress (p=-0.023, OR=0.389, 95% CI for OR=0.047, 0.843), depression (p=0.012, OR=0.659, 95% CI for OR=0.476, 0.913), and the concentration of serum vitamin D. Conclusion:This study recommends that vitamin D supplementation improve psychological state in COVID-19 patients. [ABSTRACT FROM AUTHOR]

It is well established that smoking is associated with impaired mental health and sleep problems. However, the possible effects of passive smoking on cognitive and emotional characteristics have not previously been evaluated in adolescents. We investigated the association between passive smoking and cognitive and emotional function, and sleep patterns in 940 adolescent girls. The girls were divided into two groups [305 exposed subjects and 635 non-exposed subjects (the controls)]. The passive smokers had a significantly lower cognitive function and higher depression, aggression, and insomnia scores compared to the control group (P < 0.05). No significant difference was detected with respect to day-time sleepiness and sleep apnea. Logistic regression analyses showed that the passive smokers were more likely than the controls to have cognitive impairments, depressive mood, aggressive behavior, and insomnia. Adolescent passive smokers had significant differences in their cognitive abilities and emotional function. [ABSTRACT FROM AUTHOR]

Background: It is necessary to follow up patients after recovery from COVID, and identify Psychological health. Due to the importance of psychological function accompanied by significant effects of food quality on this regard, we are going to examine the association between food quality score and psychological function among recovered COVID-19 patients. Method: In this cross-sectional study 120 individuals who had recovered from COVID-19, who were >30 years old were recruited. A valid and reliable food frequency questionnaire (FFQ) including 68 item was used to evaluate dietary intake Depression, anxiety and stress of participants was evaluated using DASS questionnaire. Multivariate linear regression analyses were conducted to investigate the relationship between food quality score and psychological function. Result: To evaluate the association between quality of life factors among FQS groups, results showed that food quality score was significantly associated with a lower body pain (P=0.017). There is significant relationship between daily fruits intake in recovered COVID-19 patients and depression which means that a higher intake leads to lower depression score (P=0.040; β= - 0.253). However, daily intake of whole grains (P=0.022, β=-0.276; P=0.001, β=-0.377; P=0.013, β=-0.300), nuts and legumes (P=0.045, β=-0.216; P=0.042, β=-0.232; P=0.033, β=-0.226) showed a reverse significant association with depression, anxiety, stress, respectively. Moreover, the analyses showed that higher intake of potato led to poor sleep quality (Table 4; P=.0.37; β= - 0.272). Also a positive significant association had been seen between refined grains' daily intake and depression, anxiety and stress score (P= 0.021, β= 0.281; P= 0.024, β= 0.249; P= 0.013, β= 0.302, respectively) as well as insomnia in recovered COVID-19 patients (P= 0.008; β= 0.293). Conclusion: Our data suggested that overall food quality intake plays a noticeable role on body pain at post infection period. Also adequate daily intake of fruits, legumes, nuts, whole grains may prevent psychological impairment and sleep disorders manifestations which are common among recovered patients. [ABSTRACT FROM AUTHOR]