1. Sequence variations in CREB1 cosegregate with depressive disorders in women.
- Author
-
Zubenko, G S, Hughes, H B, Stiffler, J S, Brechbiel, A, Zubenko, W N, Maher, B S, and Marazita, M L
- Subjects
- *
AFFECTIVE disorders , *DEPRESSED persons , *PUBLIC health - Abstract
Major depressive disorder (MDD) constitutes a major public health problem worldwide and affects women twice as frequently as men. Previous linkage studies have identified a 451 kb region of 2q33-35 that exhibited significant evidence of linkage to Mood Disorders among women (but not men) from families with recurrent, early-onset MDD (RE-MDD), a severe and strongly familial subtype of MDD. This 451 kb region includes CREB1, an attractive susceptibility gene for MDD and related disorders. Sequence variations in the CREB1 promoter and intron 8 have been detected that cosegregate with Mood Disorders, or their absence, in women from these families, identifying CREB1 as a sex-limited susceptibility gene for unipolar Mood Disorders. These findings implicate the cAMP signaling pathway in the pathophysiology of Mood Disorders and related conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2003
- Full Text
- View/download PDF