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Introduction: Carcinoma of the stratified squamous epithelium of the oral cavity - oral squamous cell carcinoma (OSCC) is an invasive pathological lesion of the epithelium with varying degrees of squamous differentiation. It is characterized by early and extensive metastases, infiltration of adjacent anatomical structures, frequent recurrences, and a relatively low five-year survival rate of less than 50%. The aim of the study to determine the correlation between the analysis of the lymphocytic infiltrate of biopsy specimens with pathohistologically proven metastases of oral squamous cellular carcinoma on postoperative neck dissection specimens. Material and methods: The study included 42 patients with pathohistologically verified oral squamous cellular carcinoma who underwent surgery at the Department of Maxillofacial Surgery of the Clinic of Dental medicine in Niš in the period from 2018 to 2022. The histopathological analysis included the depth of tumor invasion, histopathological analysis of the lymph nodes of neck dissections, analysis of lymphocytic infiltration, and presence of lymphovascularand perineural invasion. Results: It was determined that the depth of invasion is statistically significantly different regarding the degree of lymphocytic infiltration (p=0.004). Invasion of over 4mm was present in 20% of patients with high infiltration, 44.4% of patients with medium infiltration, and 85.7% of patients with low infiltration. Conclusion: Given that the results of the study indicate that the analysis of the lymphocytic infiltrate can be a reliable predictive factor of the appearance of metastases in the lymph nodes of the neck, further research should be directed toward as sociating lymphocytic infiltration with certain biochemical and genetic parameters based on which a plan can be created for neck treatment in the N0 stage of oral squamous cellular carcinoma.

Introduction: A large group of benign bone tumors of the jaw are fibroosseous tumors. The basis of the pathophysiological processes of this type of tumor is the replacement of normal bone tissue by fibrous tissue. The cemento-ossifying fibroma (COF) belongs to this group of tumors. Case report: A rare case of COF in the maxilla end maxillary sinus in a 40-year old patient is presented. In the initial stage, COF developed asymptomatically, as most benign tumors. In later stage other symptoms appeared, first of all facial deformities of the jaw and head, ophthalmic disorders, paresthesia due to compression of the nerves, and the like. We performed subtotal maxillectomy using the Weber-Fergusson approach. Conclusion: In this case report we presented a patient with rare localisation of COF. To set a definitive diagnosis of COF, a detailed clinical examination with MSCT and angiography are required. Surgical therapy is only method of treatment. Postoperative monitoring of the patient is necessary, including control MSCT radiography.

Introduction: Salivary gland tumors are extremely rare neoplasms. Given their pathohistological image, these tumors represent a great diagnostic challenge. The aim of our study was to differentiate these three tumor types by applying the immunohistochemical and morphometric analysis. Material and Methods: The entire study was conducted at the Center for Pathology and Pathological Anatomy in Niš. The study included 44 tumors, 20 pleomorphic adenomas, 12 basal cells adenomas and 12 polymorphous low-grade adenocarcinomas. The expression of Ki67, p53 and HER-2 antigens, as proliferation markers, was analyzed. The differential diagnostics also included the analysis of the expression of CEA, EMA, GFAP, p63, vimentin, CK14, α-SMA, S-100 protein and WT1 antigen. The morphometric analysis was done in the program pack 'ImageJ' version 1.43u. The statistical analysis of data was done in the program pack SPSS 15.0. Results: Neoplastic cells in pleomorphic adenoma showed a strong expression of GFAP (20/20), p63 (20/20), WT1 (20/20), vimentin (18/20) and S100 (16/20). Diffuse expression of CK14 (12/12) was present in the group of 12 polymorphous low-grade adenocarcinomas. S-100, vimentin and EMA were absolutely expressed, whereas α-SMA was negative. Basal cell adenoma showed negativity to S-100, CEA, p63 and vimentin. The analysis of the proliferative Ki67 index values pointed to a statistically significant difference in the pleomorphic adenoma group, which was associated with a frequent recurrence of this benign tumor. The analysis of morphometric characteristics showed higher values in the polymorphous low-grade adenocarcinoma group, but statistically significant differences were found only for the Feret diameter and the integrated optical density (p < 0.05). As for the basal cell adenoma group, tumor cells showed statistically higher values for the integrated optical density (p < 0.001). Conclusion: Apart from the basic micromorphological analysis, the differential analysis of salivary gland tumors also requires the immunohistochemical analysis as well as the monitoring of morphometric characteristics of these tumors' nuclei.